Search Results - "Hirschey, Matthew D."

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation by Hirschey, Matthew D., Zhao, Yingming

“…Protein acetylation is a well-studied regulatory mechanism for several cellular processes, ranging from gene expression to metabolism. Recent discoveries of…”
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Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases by Wagner, Gregory R., Hirschey, Matthew D.

“…Cellular proteins are decorated with a wide range of acetyl and other acyl modifications. Many studies have demonstrated regulation of site-specific…”
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SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome by Hirschey, Matthew D., Shimazu, Tadahiro, Jing, Enxuan, Grueter, Carrie A., Collins, Amy M., Aouizerat, Bradley, Stančáková, Alena, Goetzman, Eric, Lam, Maggie M., Schwer, Bjoern, Stevens, Robert D., Muehlbauer, Michael J., Kakar, Sanjay, Bass, Nathan M., Kuusisto, Johanna, Laakso, Markku, Alt, Frederick W., Newgard, Christopher B., Farese, Robert V., Kahn, C. Ronald, Verdin, Eric

“…Acetylation is increasingly recognized as an important metabolic regulatory posttranslational protein modification, yet the metabolic consequence of…”
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Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases by Hershberger, Kathleen A., Martin, Angelical S., Hirschey, Matthew D.

“…Key Points Nicotinamide adenine dinucleotide (NAD + ) is a coenzyme with roles in several cardiac and renal metabolic processes NAD + depletion is emerging as…”
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Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation by McDonnell, Eoin, Crown, Scott B., Fox, Douglas B., Kitir, Betül, Ilkayeva, Olga R., Olsen, Christian A., Grimsrud, Paul A., Hirschey, Matthew D.

“…Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene…”
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling by Weir, Heather J., Yao, Pallas, Huynh, Frank K., Escoubas, Caroline C., Goncalves, Renata L., Burkewitz, Kristopher, Laboy, Raymond, Hirschey, Matthew D., Mair, William B.

“…Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging…”
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Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5 by Tan, Minjia, Peng, Chao, Anderson, Kristin A., Chhoy, Peter, Xie, Zhongyu, Dai, Lunzhi, Park, Jeongsoon, Chen, Yue, Huang, He, Zhang, Yi, Ro, Jennifer, Wagner, Gregory R., Green, Michelle F., Madsen, Andreas S., Schmiesing, Jessica, Peterson, Brett S., Xu, Guofeng, Ilkayeva, Olga R., Muehlbauer, Michael J., Braulke, Thomas, Mühlhausen, Chris, Backos, Donald S., Olsen, Christian A., McGuire, Peter J., Pletcher, Scott D., Lombard, David B., Hirschey, Matthew D., Zhao, Yingming

“…We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (Kglu). This…”
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Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases by Hirschey, Matthew D.

“…Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)+-dependent deacetylases and are important modulators of energy metabolism and stress…”
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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression by Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping

“…Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a…”
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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling by Verdin, Eric, Hirschey, Matthew D., Finley, Lydia W.S., Haigis, Marcia C.

“…Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain…”
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Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal by Burkewitz, Kristopher, Morantte, Ianessa, Weir, Heather J.M., Yeo, Robin, Zhang, Yue, Huynh, Frank K., Ilkayeva, Olga R., Hirschey, Matthew D., Grant, Ana R., Mair, William B.

“…Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved…”
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A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation by Wagner, Gregory R, Bhatt, Dhaval P, O'Connell, Thomas M, Thompson, J Will, Dubois, Laura G, Backos, Donald S, Yang, Hao, Mitchell, Grant A, Ilkayeva, Olga R, Stevens, Robert D, Grimsrud, Paul A, Hirschey, Matthew D

“…The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA…”
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Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production by Jing, Enxuan, Emanuelli, Brice, Hirschey, Matthew D., Boucher, Jeremie, Lee, Kevin Y., Lombard, David, Verdin, Eric M., Kahn, C. Ronald

“…Sirt3 is a member of the sirtuin family of protein deacetylases that is localized in mitochondria and regulates mitochondrial function. Sirt3 expression in…”
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Mitochondrial protein acetylation regulates metabolism by Anderson, Kristin A, Hirschey, Matthew D

“…Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the…”
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα by Naiman, Shoshana, Huynh, Frank K., Gil, Reuven, Glick, Yair, Shahar, Yael, Touitou, Noga, Nahum, Liat, Avivi, Matan Y., Roichman, Asael, Kanfi, Yariv, Gertler, Asaf A., Doniger, Tirza, Ilkayeva, Olga R., Abramovich, Ifat, Yaron, Orly, Lerrer, Batia, Gottlieb, Eyal, Harris, Robert A., Gerber, Doron, Hirschey, Matthew D., Cohen, Haim Y.

“…The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in…”
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Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight by Rajabi, Nima, Auth, Marina, Troelsen, Kathrin R., Pannek, Martin, Bhatt, Dhaval P., Fontenas, Martin, Hirschey, Matthew D., Steegborn, Clemens, Madsen, Andreas S., Olsen, Christian A.

“…The sirtuin enzymes are important regulatory deacylases in a variety of biochemical contexts and may therefore be potential therapeutic targets through either…”
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Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism by Gut, Philipp, Baeza-Raja, Bernat, Andersson, Olov, Hasenkamp, Laura, Hsiao, Joseph, Hesselson, Daniel, Akassoglou, Katerina, Verdin, Eric, Hirschey, Matthew D, Stainier, Didier Y R

“…Maintaining energy homeostasis requires complex feedback across organs that is difficult to study in isolated systems. New research uses whole-organism…”
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Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation by Lombard, David B., Alt, Frederick W., Cheng, Hwei-Ling, Bunkenborg, Jakob, Streeper, Ryan S., Mostoslavsky, Raul, Kim, Jennifer, Yancopoulos, George, Valenzuela, David, Murphy, Andrew, Yang, Yinhua, Chen, Yaohui, Hirschey, Matthew D., Bronson, Roderick T., Haigis, Marcia, Guarente, Leonard P., Farese, Robert V., Weissman, Sherman, Verdin, Eric, Schwer, Bjoern

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH by Madsen, Andreas S., Andersen, Christian, Daoud, Mohammad, Anderson, Kristin A., Laursen, Jonas S., Chakladar, Saswati, Huynh, Frank K., Colaço, Ana R., Backos, Donald S., Fristrup, Peter, Hirschey, Matthew D., Olsen, Christian A.

“…Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular…”
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Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice by Fritz, Kristofer S, Galligan, James J, Hirschey, Matthew D, Verdin, Eric, Petersen, Dennis R

“…Mitochondrial protein hyperacetylation is a known consequence of sustained ethanol consumption and has been proposed to play a role in the pathogenesis of…”
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