Search Results - "Hirschberg, Henry"

Fibrin glue mediated direct delivery of radiation sensitizers results in enhanced efficacy of radiation treatment by Nguyen, Jane, Chandekar, Akhil, Laurel, Sophia, Dosanjh, Jazleen, Gupta, Keya, Le, Justin, Hirschberg, Henry

“…Purpose Radiation therapy (RT) plays an important role in the treatment of glioblastoma multiforme (GBM). However, inherent intrinsic resistance of tumors to…”
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Site-specific opening of the blood-brain barrier by Madsen, Steen J., Hirschberg, Henry

“…The blood‐brain barrier (BBB) poses a significant impediment for the delivery of therapeutic drugs into the brain. This is particularly problematic for the…”
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Characterizing low fluence thresholds for in vitro photodynamic therapy by Hartl, Brad A, Hirschberg, Henry, Marcu, Laura, Cherry, Simon R

“…The translation of photodynamic therapy (PDT) to the clinic has mostly been limited to superficial diseases where traditional light delivery is noninvasive. To…”
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The effects of low irradiance long duration photochemical internalization on glioma spheroids by Shin, Diane, Nguyen, Lina, T Le, Mai, Ju, David, N Le, Jimmy, Berg, Kristian, Hirschberg, Henry

“…•BLM-mPCI delivered over an extended period of time resulted in significant spheroid growth inhibition.•Metronomic PCI (mPCI) had increased effectiveness…”
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Disruption of the blood-brain barrier following ALA-mediated photodynamic therapy by Hirschberg, Henry, Uzal, Francisco A., Chighvinadze, David, Zhang, Michelle J., Peng, Qian, Madsen, Steen J.

“…Background and Objective Photodynamic therapy (PDT) is a local antineoplastic treatment with the potential for tumor cell specificity. PDT using either…”
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Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization by Madsen, Steen J, Gonzales, Jonathan, Zamora, Genesis, Berg, Kristian, Nair, Rohit Kumar, Hirschberg, Henry

“…Photochemical internalization (PCI) is a technique that uses the photochemical properties of photodynamic therapy (PDT) for the enhanced delivery of…”
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The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids by Mathews, Marlon S., Angell-Petersen, Even, Sanchez, Rogelio, Sun, Chung-Ho, Vo, Van, Hirschberg, Henry, Madsen, Steen J.

“…Background and Objective Achieving local control of gliomas with photodynamic therapy (PDT) requires the delivery of adequate light fluences to depths of 1–2…”
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Targeted delivery of bleomycin to the brain using photo-chemical internalization of Clostridium perfringens epsilon prototoxin by Hirschberg, Henry, Zhang, Michelle J., Gach, H. Michael, Uzal, Francisco A., Peng, Qian, Sun, Chung-Ho, Chighvinadze, David, Madsen, Steen J.

“…Cells infiltrating into normal brain from malignant brain tumors are protected by the blood brain barrier (BBB) which prevents the delivery and limits the…”
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Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model by ANGELL-PETERSEN, Even, SPETALEN, Signe, MADSEN, Steen J, SUN, Chung-Ho, QIAN PENG, CARPER, Stephen W, SIOUD, Mouldy, HIRSCHBERG, Henry

“…Failure of treatment for high-grade gliomas is usually due to local recurrence at the site of resection, indicating that a more aggressive local therapy could…”
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5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (review) by Friesen, Scott A, Hjortland, Geir Olav, Madsen, Steen J, Hirschberg, Henry, Engebraten, Olav, Nesland, Jahn M, Peng, Qian

“…With current treatment methods the prognosis for patients with aggressive brain tumors is dismal. Treatment failure is usually due to local recurrence of…”
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Photodynamic therapy of newly implanted glioma cells in the rat brain by Madsen, Steen J., Angell-Petersen, Even, Spetalen, Signe, Carper, Stephen W., Ziegler, Sarah A., Hirschberg, Henry

“…Background and Objective A syngeneic rat brain tumor model is used to investigate the effects of aminolevulinic acid (ALA)‐mediated photodynamic therapy (PDT)…”
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Photodynamic Therapy of Human Glioma Spheroids Using 5-Aminolevulinic Acid by Madsen, Steen J., Sun, Chung-Ho, Tromberg, Bruce J., Wallace, Vincent P., Hirschberg, Henry

“…The response of human glioma spheroids to 5-aminolevulinic acid (ALA)–mediated photodynamic therapy (PDT) is investigated. A two-photon fluorescence microscopy…”
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SCDT-16. ENHANCING THE EFFICACY OF CHEMOTHERAPY BY FOCUSED ULTRASOUND MEDIATED SONOCHEMICAL INTERNALIZATION (SCI) by Hirschberg, Henry, Madsen, Steen

“…Systemically administered chemotherapeutic agents are, firstly limited by their inability to penetrate across the blood brain barrier (BBB). Site-specific…”
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Ultrasound mediated sonochemical internalization (SCI): overcoming the depth limitations of light-based therapies by Hirschberg, Henry, Madsen, Steen J, Nguyen, Lina

“…Focused ultrasound activation of sonosensitizers i.e. sonodynamic therapy (SDT) is an alternative to light-activated photodynamic therapy (PDT). Sonochemical…”
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Plasminogen activator inhibitor-1 increases the expression of VEGF in human glioma cells by Hjortland, Geir Olav, Lillehammer, Trine, Somme, Stig, Wang, Junbai, Halvorsen, Thomas, Juell, Siri, Hirschberg, Henry, Fodstad, Øystein, Engebraaten, Olav

“…The level of plasminogen activator inhibitor-1 (PAI-1) in tumor tissue has been shown to be an independent negative prognostic factor in different cancers…”
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SCIDOT-25. ENHANCING THE EFFICACY OF DRUG RELEASED FROM LOADED FIBRIN GLUE BY PHOTOCHEMICAL INTERNALIZATION (PCI) by Hirschberg, Henry, Nguven, Lina, Johnsen, Julie

“…Abstract Although gross total resection of gliomas is often possible with current available techniques, almost all tumors recur due to the infiltrative nature…”
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The use of fibrin glue for the local delivery of drugs and photosensitizers in photochemical internalization by Madsen, Steen J., Chandekar, Akhil, Nguyen, Lina, Hirschberg, Henry

“…Implantation of drug-loaded hydrogels, such as fibrin glue (FG), into the tumor resection cavity has the potential to overcome the poor penetration of drugs…”
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SYST-10 ENHANCING THE EFFICACY OF RADIATION THERAPY BY SURGICALLY TARGETED RADIATION-SENSITIZER LOADED FIBRIN GLUE by Nguyen, Jane, Chandekar, Akhil, Hirschberg, Henry

“…Abstract Radiation therapy (RT) forms an integral part of the treatment of brain tumors. Intrinsic, relative tumor radio-resistance, normal tissue tolerance…”
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Cell Mediated Photothermal Therapy of Brain Tumors by Hirschberg, Henry, Madsen, Steen J.

“…Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to…”
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Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy by Sun, Chung-Ho, Berg, Kristian, Hirschberg, Henry

“…Nonviral gene transfection overcomes some of the disadvantages of viral vectors, such as undesired immune responses, safety concerns, issues relating to bulk…”
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