Search Results - "Hirschberg, Carlos B."

A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites by Caffaro, Carolina E, Koshy, Anita A, Liu, Li, Zeiner, Gusti M, Hirschberg, Carlos B, Boothroyd, John C

“…Toxoplasma gondii is an intracellular parasite that transitions from acute infection to a chronic infective state in its intermediate host via encystation,…”
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Nucleotide Sugar Transporters of the Golgi Apparatus:  From Basic Science to Diseases by Caffaro, Carolina E, Hirschberg, Carlos B

“…Approximately 80% of secreted and membrane proteins (40% of all proteins) of eukaryotes become covalently linked to sugars in the lumen of the Golgi apparatus,…”
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Inhibition of Golgi Apparatus Glycosylation Causes Endoplasmic Reticulum Stress and Decreased Protein Synthesis by Xu, Yu-Xin, Liu, Li, Caffaro, Carolina E., Hirschberg, Carlos B.

“…Nucleotide sugar transporters of the Golgi apparatus play an essential role in the glycosylation of proteins, lipids, and proteoglycans. Down-regulation of…”
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My journey in the discovery of nucleotide sugar transporters of the Golgi apparatus by Hirschberg, Carlos B.

“…Defects in protein glycosylation can have a dramatic impact on eukaryotic cells and is associated with mental and developmental pathologies in humans. The…”
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A Course in Critical Thinking for PhD Students in Biomolecular Sciences and Biotechnology: Classical Experiments in Biochemistry by Hirschberg, Carlos B.

“…This essay presents and discusses an eight-session seminar course designed to develop critical thinking skills in doctoral biochemistry students by exposing…”
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N-Glycans of Caenorhabditis elegans Are Specific to Developmental Stages by Cipollo, John F., Awad, Antoine M., Costello, Catherine E., Hirschberg, Carlos B.

“…We have examined the N-glycans present during the developmental stages of Caenorhabditis elegans using two approaches, 1) a combination of permethylation…”
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TRANSPORTERS OF NUCLEOTIDE SUGARS, ATP, AND NUCLEOTIDE SULFATE IN THE ENDOPLASMIC RETICULUM AND GOLGI APPARATUS by Hirschberg, Carlos B, Robbins, Phillips W, Abeijon, Claudia

“…The lumens of the endoplasmic reticulum and Golgi apparatus are the subcellular sites where glycosylation, sulfation, and phosphorylation of secretory and…”
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Independent and Simultaneous Translocation of Two Substrates by a Nucleotide Sugar Transporter by Caffaro, Carolina E., Hirschberg, Carlos B., Berninsone, Patricia M.

“…Nucleotide sugar transporters play an essential role in protein and lipid glycosylation, and mutations can result in developmental phenotypes. We have…”
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Chris Raetz, scientist and enduring friend by Wickner, William T., Stubbe, JoAnne, Hirschberg, Carlos B., Garrett, Teresa, Dowhan, William

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Developmental diseases caused by impaired nucleotide sugar transporters by Liu, Li, Hirschberg, Carlos B.

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srf-3, a Mutant of Caenorhabditis elegans, Resistant to Bacterial Infection and to Biofilm Binding, Is Deficient in Glycoconjugates by Cipollo, John F., Awad, Antoine M., Costello, Catherine E., Hirschberg, Carlos B.

“…srf-3 is a mutant of C. elegans that is resistant to infection by Microbacterium nematophilum and to binding of the biofilm produced by Yersinia…”
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SQV-7, A Protein Involved in Caenorhabditis elegans Epithelial Invagination and Early Embryogenesis, Transports UDP-Glucuronic Acid, UDP-N-Acetylgalactosamine, and UDP-Galactose by Berninsone, Patricia, Hwang, Ho-Yon, Zemtseva, Irina, Horvitz, H. Robert, Hirschberg, Carlos B.

“…Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7…”
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Functional Redundancy between Two Caenorhabditis elegans Nucleotide Sugar Transporters with a Novel Transport Mechanism by Caffaro, Carolina E., Hirschberg, Carlos B., Berninsone, Patricia M.

“…Transporters of nucleotide sugars regulate the availability of these substrates required for glycosylation reactions in the lumen of the Golgi apparatus and…”
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Loss of srf-3-encoded Nucleotide Sugar Transporter Activity in Caenorhabditis elegans Alters Surface Antigenicity and Prevents Bacterial Adherence by Jörg Höflich, Patricia Berninsone, Christine Göbel, Maria J. Gravato-Nobre, Brian J. Libby, Creg Darby, Samuel M. Politz, Jonathan Hodgkin, Carlos B. Hirschberg, Ralf Baumeister

“…During the establishment of a bacterial infection, the surface molecules of the host organism are of particular importance, since they mediate the first…”
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The Fine Structure of Caenorhabditis elegans N-Glycans by Cipollo, John F, Costello, Catherine E, Hirschberg, Carlos B

“…We report the fine structure of a nearly contiguous series of N -glycans from the soil nematode Caenorhabditis elegans. Five major classes are revealed…”
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Golgi and Endoplasmic Reticulum Functions Take Place in Different Subcellular Compartments of Entamoeba histolytica by Bredeston, Luis M., Caffaro, Carolina E., Samuelson, John, Hirschberg, Carlos B.

“…Entamoeba histolytica is a protozoan parasite that causes dysentery in developing countries of Africa, Asia, and Latin America. The lack of a defined Golgi…”
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Mammalian Golgi Apparatus UDP-N-acetylglucosamine Transporter: Molecular Cloning by Phenotypic Correction of a Yeast Mutant by Guillen, Eduardo, Abeijon, Claudia, Hirschberg, Carlos B.

“…Transporters in the Golgi apparatus membrane translocate nucleotide sugars from the cytosol into the Golgi lumen before these can be substrates for the…”
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Biosynthesis in vitro of Caenorhabditis elegans Phosphorylcholine Oligosaccharides by Cipollo, John F., Awad, Antoine, Costello, Catherine E., Robbins, Phillips W., Hirschberg, Carlos B.

“…The biosynthesis in vitro of phosphorylcholine oligosaccharides in Caenorhabditis elegans has been investigated. Here we show that extracts of C. elegans'…”
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The role of nucleotide sugar transporters in development of eukaryotes by Liu, Li, Xu, Yu-Xin, Hirschberg, Carlos B.

“…The Golgi apparatus membrane of all eukaryotes has nucleotide sugar transporters which play essential roles in the glycosylation of glycoproteins,…”
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Developmental diseases caused by impaired nucleotide sugar transporters by Liu, Li, Hirschberg, Carlos B.

“…Nucleotide sugar transporters play critical roles in glycosylation of proteins, lipids and proteoglycans, which are essential for organogenesis, development,…”
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