Search Results - "Hirsch, Vanessa M."

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers by Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A, Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I, Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M, Edlefsen, Paul T, Piatak, Michael, Estes, Jacob D, Lifson, Jeffrey D, Picker, Louis J

“…Fukazawa et al . report that SIV persists in follicular helper T cells in elite controller macaques, evading clearance by CD8+ T cells Chronic-phase HIV and…”
Get full text

The Host Restriction Factor APOBEC3G and Retroviral Vif Protein Coevolve due to Ongoing Genetic Conflict by Compton, Alex A., Hirsch, Vanessa M., Emerman, Michael

“…APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its…”
Get full text

Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections by DiNapoli, Sarah R, Hirsch, Vanessa M, Brenchley, Jason M

“…The cells that are targeted by primate lentiviruses (HIV and simian immunodeficiency virus [SIV]) are of intense interest given the renewed effort to identify…”
Get full text

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species by Kirmaier, Andrea, Wu, Fan, Newman, Ruchi M, Hall, Laura R, Morgan, Jennifer S, O'Connor, Shelby, Marx, Preston A, Meythaler, Mareike, Goldstein, Simoy, Buckler-White, Alicia, Kaur, Amitinder, Hirsch, Vanessa M, Johnson, Welkin E

“…Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in…”
Get full text

Budding of a Retrovirus: Some Assemblies Required by Rose, Kevin M, Hirsch, Vanessa M, Bouamr, Fadila

“…One of the most important steps in any viral lifecycle is the production of progeny virions. For retroviruses as well as other viruses, this step is a highly…”
Get full text

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections by Estes, Jacob D, Harris, Levelle D, Klatt, Nichole R, Tabb, Brian, Pittaluga, Stefania, Paiardini, Mirko, Barclay, G Robin, Smedley, Jeremy, Pung, Rhonda, Oliveira, Kenneth M, Hirsch, Vanessa M, Silvestri, Guido, Douek, Daniel C, Miller, Christopher J, Haase, Ashley T, Lifson, Jeffrey, Brenchley, Jason M

“…The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than…”
Get full text

Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells by Calantone, Nina, Wu, Fan, Klase, Zachary, Deleage, Claire, Perkins, Molly, Matsuda, Kenta, Thompson, Elizabeth A., Ortiz, Alexandra M., Vinton, Carol L., Ourmanov, Ilnour, Loré, Karin, Douek, Daniel C., Estes, Jacob D., Hirsch, Vanessa M., Brenchley, Jason M.

“…The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of…”
Get full text

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation by Chiramel, Abhilash I, Meyerson, Nicholas R, McNally, Kristin L, Broeckel, Rebecca M, Montoya, Vanessa R, Méndez-Solís, Omayra, Robertson, Shelly J, Sturdevant, Gail L, Lubick, Kirk J, Nair, Vinod, Youseff, Brian H, Ireland, Robin M, Bosio, Catharine M, Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M, Taylor, R Travis, Bouamr, Fadila, Sawyer, Sara L, Best, Sonja M

“…Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity…”
Get full text

The Canarypox Virus Vector ALVAC Induces Distinct Cytokine Responses Compared to the Vaccinia Virus-Based Vectors MVA and NYVAC in Rhesus Monkeys by Teigler, Jeffrey E, Phogat, Sanjay, Franchini, Genoveffa, Hirsch, Vanessa M, Michael, Nelson L, Barouch, Dan H

“…OA  Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts by Silvestri, Guido, Sodora, Donald L, Allan, Jonathan S, Apetrei, Cristian, Brenchley, Jason M, Douek, Daniel C, Else, James G, Estes, Jacob D, Hahn, Beatrice H, Hirsch, Vanessa M, Kaur, Amitinder, Kirchhoff, Frank, Muller-Trutwin, Michaela, Pandrea, Ivona, Schmitz, Jörn E

“…The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine…”
Get full text

Mutation in the Disordered Linker Region of Capsid Disrupts Viral Kinetics of a Neuropathogenic SIV in Rhesus Macaques by Lee, Cheri A, Hirsch, Vanessa M

“…TRIM5α polymorphism in rhesus macaques (RM) limits the genetic pool of animals in which we can perform simian immunodeficiency virus (SIV) studies without…”
Get full text

A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques by Matsuda, Kenta, Riddick, Nadeene E, Lee, Cheri A, Puryear, Sarah B, Wu, Fan, Lafont, Bernard A P, Whitted, Sonya, Hirsch, Vanessa M

“…Despite effective control of plasma viremia with the use of combination antiretroviral therapies (cART), minor cognitive and motor disorders (MCMD) persist as…”
Get full text

Simian Immunodeficiency Virus-Infected Memory CD4 + T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS by Lee, Cheri A, Beasley, Erin, Sundar, Karthikeyan, Smelkinson, Margery, Vinton, Carol, Deleage, Claire, Matsuda, Kenta, Wu, Fan, Estes, Jake D, Lafont, Bernard A P, Brenchley, Jason M, Hirsch, Vanessa M

“…Simian immunodeficiency virus (SIV)-infected nonhuman primates can serve as a relevant model for AIDS neuropathogenesis. Current SIV-induced encephalitis…”
Get full text

Erratum: Rose et al. When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding. Viruses 2021, 13 , 1138 by Rose, Kevin M, Spada, Stephanie J, Hirsch, Vanessa M, Bouamr, Fadila

“…The authors wish to make the following erratum to this paper [...]…”
Get full text

From Capsids to Complexes: Expanding the Role of TRIM5α in the Restriction of Divergent RNA Viruses and Elements by Rose, Kevin M, Spada, Stephanie J, Broeckel, Rebecca, McNally, Kristin L, Hirsch, Vanessa M, Best, Sonja M, Bouamr, Fadila

“…An evolutionary arms race has been ongoing between retroviruses and their primate hosts for millions of years. Within the last century, a zoonotic transmission…”
Get full text

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors by Riddick, Nadeene E, Wu, Fan, Matsuda, Kenta, Whitted, Sonya, Ourmanov, Ilnour, Goldstein, Simoy, Goeken, Robert M, Plishka, Ronald J, Buckler-White, Alicia, Brenchley, Jason M, Hirsch, Vanessa M

“…African green monkeys (AGM) are natural hosts of simian immunodeficiency virus (SIV), and infection in these animals is generally nonpathogenic, whereas…”
Get full text

CD4-Like Immunological Function by CD4− T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus by VINTON, Carol, KLATT, Nichole R, HIRSCH, Vanessa M, BRENCHLEY, Jason M, HARRIS, Levelle D, BRIANT, Judith A, SANDERS-BEER, Brigitte E, HERBERT, Richard, WOODWARD, Ruth, SILVESTRI, Guido, PANDREA, Ivona, APETREI, Cristian

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

TRIM5 alpha drives SIVsmm evolution in rhesus macaques by Wu, Fan, Kirmaier, Andrea, Goeken, Robert, Ourmanov, Ilnour, Hall, Laura, Morgan, Jennifer S, Matsuda, Kenta, Buckler-White, Alicia, Tomioka, Keiko, Plishka, Ronald, Whitted, Sonya, Johnson, Welkin, Hirsch, Vanessa M

“…The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of…”
Get full text

Laser Capture Microdissection Assessment of Virus Compartmentalization in the Central Nervous Systems of Macaques Infected with Neurovirulent Simian Immunodeficiency Virus by Matsuda, Kenta, Brown, Charles R, Foley, Brian, Goeken, Robert, Whitted, Sonya, Dang, Que, Wu, Fan, Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Sequential Evolution and Escape from Neutralization of Simian Immunodeficiency Virus SIVsmE660 Clones in Rhesus Macaques by Wu, Fan, Ourmanov, Ilnour, Kuwata, Takeo, Goeken, Robert, Brown, Charles R, Buckler-White, Alicia, Iyengar, Ranjini, Plishka, Ronald, Aoki, Scott T, Hirsch, Vanessa M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text