Search Results - "Hirsch, Kenneth S."

Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase by Jones, Charles D, Audia, James E, Lawhorn, David E, McQuaid, Loretta A, Neubauer, Blake L, Pike, Andrew J, Pennington, Pamela A, Stamm, Nancy B, Toomey, Richard E, Hirsch, Kenneth S

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Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups by Jones, C. David, Winter, Mark A, Hirsch, Kenneth S, Stamm, Nancy, Taylor, Harold M, Holden, Howard E, Davenport, James D, Krumkalns, Eriks V, Suhr, Robert G

“…The preparation and in vitro aromatase inhibitory activity of a wide variety of heterocyclic (4,4'-dichlorodiphenyl)methanes and -methanols are described. The…”
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Platelet derived growth factor (PDGF), androgens and inflammation: possible etiologic factors in the development of prostatic hyperplasia by Gleason, P E, Jones, J A, Regan, J S, Salvas, D B, Eble, J N, Lamph, W W, Vlahos, C J, Huang, W L, Falcone, J F, Hirsch, K S

“…Benign prostatic hyperplasia (BPH) is characterized by varying degrees of epithelial and stromal hyperplasia in association with inflammation. Although…”
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Inhibition of central nervous system aromatase activity: a mechanism for fenarimol-induced infertility in the male rat by Hirsch, K S, Weaver, D E, Black, L J, Falcone, J F, MacLusky, N J

“…Fenarimol (alpha-(2-chlorophenyl)-alpha(4-chlorophenyl)-5-pyrimidine-methanol), a pyrimidine carbinol agricultural fungicide, was previously reported to cause…”
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Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines by Taylor, Harold M, Jones, C. David, Davenport, James D, Hirsch, Kenneth S, Kress, T. J, Weaver, Dix

“…The inhibition of estrogen biosynthesis has been suggested to be an effective treatment of hormone-dependent diseases, particularly breast cancer. Several…”
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Binding of insulin-like growth factors to tera-2 human embryonal carcinoma cells during differentiation by FLECK, J. F, SLEDGE, G. W, BENENATI, S. V, FROLIK, C. A, ROTH, B. J, HIRSCH, K. S

“…Differentiation of Tera-2 human embryonal carcinoma cells by exposure to 2.1 mM alpha-difluoromethylornithine resulted in changes in morphology, a decrease in…”
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Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups [Erratum to document cited in CA112(5):35753f] by Jones, C, David, Winter, Mark, A, Hirsch, Kenneth S, Stamm, Nancy, Taylor, Harold M, Holden, Howard E, Davenport, James D, Krumkalns, Eriks V, Suhr, Robert G

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Relationship of dietary zinc to 6-mercaptopurine teratogenesis and DNA metabolism in the rat by Hirsch, K S, Hurley, L S

“…The possible interaction between the level of maternal dietary zinc and the teratogenic activity of 6-mercaptopurine was investigated. Pregnant Sprague-Dawley…”
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Attenuating effect of zinc on abnormal placental morphology in 6-mercaptopurine treated rats by Shrader, R E, Hirsch, K S, Levin, J, Hurley, L S

“…Pregnant Sprague-Dawley rats were fed diets containing 9 (marginal level), 100 (control level), or 1,000 (very high level) ppm zinc and were given a single…”
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LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5α- Reductase Type 1 by Hirsch, Kenneth S., Jones, Charles D., Audia, James E., Andersson, Stefan, McQuaid, Loretta, Stamm, Nancy B., Neubauer, Blake L., Pennington, Pam, Toomey, Richard E., Russell, David W.

“…Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT…”
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Platelet-derived growth factor induces proliferation of hyperplastic human prostatic stromal cells by Vlahos, C J, Kriauciunas, T D, Gleason, P E, Jones, J A, Eble, J N, Salvas, D, Falcone, J F, Hirsch, K S

“…Prostatic hyperplasia (BPH) is a very common disease in elderly men and is characterized by abnormal proliferation of the stromal and epithelial cells of the…”
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LY191704: A selective, nonsteroidal inhibitor of human steroid 5(alpha)-reductase type 1 by Hirsch, Kenneth S, Jones, Charles D, Audia, James E, Andersson, Stefan

“…A nonsteroidal inhibitor of 5alpha-reductase type 1, LY191704, is described. Results suggest that LY191704 may be useful in treatment of human endocrine…”
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LY191704 inhibits type I steroid 5α-reductase in human scalp by NEUBAUER, B. L, GRAY, H. M, TINDALL, D. J, TOOMEY, R. E, YAO, R. C, AUDIA, J. E, HANKE, C. W, HIRSCH, K. S, HSIAO, K. C, JONES, C. D, KUMAR, M. V, LAWHORN, D. E, LINDZEY, J, MCQUAID, L

“…Conversion of testosterone to dihydrotestosterone (DHT) has been demonstrated to be catalyzed by two isoforms of steroid 5 alpha-reductase, designated types I…”
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LY207320 (6-methylene-4-pregnene-3,20-dione) inhibits testosterone biosynthesis, androgen uptake, 5 alpha-reductase, and produces prostatic regression in male rats by Neubauer, B L, Best, K L, Blohm, T R, Gates, C, Goode, R L, Hirsch, K S, Laughlin, M E, Petrow, V, Smalstig, E B, Stamm, N B

“…LY207320 is an in vitro inhibitor (estimated IC50 = 0.06 microM) of steroid 5 alpha-reductase that catalyzes the conversion of testosterone (T) to…”
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Endocrine effects of a new histamine H2-receptor antagonist, nizatidine (LY139037), in the male rat by Neubauer, B L, Goode, R L, Best, K L, Hirsch, K S, Lin, T M, Pioch, R P, Probst, K S, Tinsley, F C, Shaar, C J

“…A new orally active histamine H2-receptor antagonist, nizatidine (LY139037), was evaluated in male rats for effects on mechanisms regulating accessory sex…”
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Discovery and development of a novel class of nonsteroidal aromatase inhibitors by Hirsch, K S, Jones, C D, Lindstrom, T D, Stamm, N B, Sutton, G P, Taylor, H M, Weaver, D E

“…Efforts to develop a novel class of nonsteroidal aromatase inhibitors began with the discovery that the infertility in male rats exposed to high levels of the…”
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Studies to elucidate the mechanism of fenarimol-induced infertility in male rats by Hirsch, K S, Adams, E R, Hoffman, D G, Markham, J K, Owen, N V

“…Fenarimol (alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5- pyrimidinemethanol a pyrimidine carbinol fungicide, caused a dose-related decrease in male…”
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Translocatable estrogen receptors in rat splenocytes by Myers, M J, Heim, M C, Hirsch, K S, Queener, S F, Petersen, B H

“…Estradiol has previously been shown to suppress the response of the cellular immune system of the rat while enhancing the production of IgM antibodies…”
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Teratogenic effects of mescaline, epinephrine, and norepinephrine in the hamster by Hirsch, K S, Fritz, H I

“…Mescaline was administered orally at doses of 16 and 32 mg/kg on the seventh through tenth days of gestation to pregnant cream-strain hamsters. This treatment…”
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Acetazolamide teratology and its association with carbonic anhydrase inhibition in the mouse by Hirsch, K S, Wilson, J G, Scott, W J, O'Flaherty, E J

“…Acetazolamide, an inhibitor of the enzyme carbonic anhydrase (E.C. 4.2.1.1.), causes a unique congenital anomaly characterized by postaxial reduction of the…”
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