Search Results - "Hirsch, Jonathan"

Data silos are undermining drug development and failing rare disease patients by Denton, Nathan, Molloy, Monique, Charleston, Samantha, Lipset, Craig, Hirsch, Jonathan, Mulberg, Andrew E, Howard, Paul, Marsh, Eric D

“…Data silos are proliferating while research and development activity explode following genetic and immunological advances for many clinically described…”
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Rapid real‐world data analysis of patients with cancer, with and without COVID‐19, across distinct health systems by Hwang, Clara, Izano, Monika A., Thompson, Michael A., Gadgeel, Shirish M., Weese, James L., Mikkelsen, Tom, Schrag, Andrew, Teka, Mahder, Walters, Sheetal, Wolf, Frank M., Hirsch, Jonathan, Rivera, Donna R., Kluetz, Paul G., Singh, Harpreet, Brown, Thomas D.

“…Background The understanding of the impact of COVID‐19 in patients with cancer is evolving, with need for rapid analysis. Aims This study aims to compare the…”
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Albugranin, a recombinant human granulocyte colony stimulating factor (G-CSF) genetically fused to recombinant human albumin induces prolonged myelopoietic effects in mice and monkeys by HALPERN, Wendy, RICCOBENE, Todd A, GRZEGORZEWSKI, Krzysztof J, AGOSTINI, Heidi, BAKER, Kevin, STOLOW, David, GU, Mi-Li, HIRSCH, Jonathan, MAHONEY, Angela, CARRELL, Jeffrey, BOYD, Ernest

“…Albugranin fusion protein is recombinant granulocyte colony stimulating factor (rG-CSF) genetically fused at its N-terminus to the C-terminus of recombinant…”
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Clinical Evaluation of a Titanium, Headless Variable-Pitched Tapered Cannulated Compression Screw for Repair of Frontal Plane Slab Fractures of the Third Carpal Bone in Thoroughbred Racehorses by HIRSCH, JONATHAN E, GALUPPO, LARRY D, GRAHAM, LINDSAY E, SIMPSON, EDWIN L, FERRARO, GREGORY L

“…To report clinical evaluation of third carpal bone (C3) frontal plane slab fracture repair with the Acutrak® screw system. Prospective case series. Racing…”
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Molecular alterations with hyperprogression in lung cancer patients treated with immune checkpoint inhibitors in a large health system by Tadesse, Eyob ale, Heslin, Kayla, Hendawi, Mohamed, Hirsch, Jonathan, Idyro, Christopher, Thompson, Michael A.

“…Abstract only e15082 Background: Immune checkpoint inhibitor (ICI) therapy has become a mainstay of lung cancer treatment. However, not all NSCLC patients…”
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Overall survival in high and very high PD-L1 expressing patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors in a real-world data setting by Zhang, Chenan, Sweetnam, Connor, Wolf, Frank, Walters, Sheetal, Hirsch, Jonathan, Brown, Thomas D.

“…Abstract only e15156 Background: Clinical trials show improved survival for advanced non-small cell lung cancer (aNSCLC) patients whose tumors are positive for…”
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An algorithmic approach to deriving line of therapy in a real-world data set for non-small cell lung cancer (NSCLC) by Shadra, Chhaya, Chen, James Lin, Cho-Phan, Cheryl D., Ghosh, Aradhana, Hirsch, Jonathan

“…Abstract only e18099 Background: Real World Data (RWD) is being used for outcomes research and regulatory submissions. A key variable needed to understand…”
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Deriving real-world oral antineoplastic treatment endpoints: A comparison of automated data extraction versus manual chart abstraction by Chen, James Lin, Shadra, Chhaya, Cho-Phan, Cheryl D., Ghosh, Aradhana, Hirsch, Jonathan

“…Abstract only e18070 Background: Real world data (RWD) is increasingly being used to generate evidence that informs clinical care. Calculating outcomes…”
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Abstract 1676: A hybrid ontology and graph system enabling precision oncology applications through real-time incorporation of omics biomarkers into a scalable real-world data platform by Shima, James E., Chen, James L., Glick, Matthew J., Warrier, Ryan A., Abruzzese, Eric C., Mankowski, Walter C., Hirsch, Jonathan

“…Abstract Background: The ability to produce timely, clinically actionable recommendations is a cornerstone of a robust precision oncology program. This…”
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Abstract CT086: Pneumonitis incidence in patients with non-small cell lung cancer treated with immunotherapy or chemotherapy in clinical trials and real-world data by Liu, Qi, Zhang, Chenan, Gong, Yutao, Zhu, Hao, Chang, Elaine, Cho-Phan, Cheryl, Hirsch, Jonathan, Thompson, Michael A., Blumenthal, Gideon, Huang, Shiew Mei, Brown, Thomas D.

“…Abstract Background: Pneumonitis (Pn) is a potentially life-threatening adverse event of some anticancer drugs. We compared treatment associated pneumonitis…”
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Design and implementation of an informatics infrastructure for actionable precision oncology by Hirsch, Jonathan, Ford, James M., Nadauld, Lincoln, Hsu, Andro

“…Abstract only…”
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The role of real-world evidence in clinical care: A survey of oncology leaders by Stahl, Melissa, Winzeler, Alissa M, Zaman, Ali, Shelby, Nicole, Chen, James Lin, Clutz, Bryan, Ghosh, Aradhana, Hirsch, Jonathan

“…Abstract only…”
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Abstract S10-02: Using real-world data (RWD) from an integrated platform for rapid analysis of patients with cancer with and without COVID-19 across distinct health systems by Gadgeel, Shirish M., Thompson, Michael A., Izano, Monika A., Hwang, Clara, Mikkelsen, Tom, Weese, James L., Wolf, Frank M., Schrag, Andrew, Walters, Sheetal, Singh, Harpreet, Hirsch, Jonathan, Brown, Thomas D., Kluetz, Paul G.

“…Abstract Introduction: Reports suggest worsened outcomes in patients with cancer (pts) and COVID-19 (Cov), varying by geography and local peak dynamics. We…”
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Outcomes in patients with advanced non-small cell lung cancer (aNSCLC) and high PD-L1 expression treated with immune checkpoint inhibitor monotherapy: An FDA-pooled analysis by Shah, Sujay Yogesh, Vallejo, Jonathon Joseph, Gong, Yutao, Brown, Thomas D., Zhang, Chenan, Hirsch, Jonathan, Tang, Shenghui, Blumenthal, Gideon Michael, Singh, Harpreet, Kluetz, Paul Gustav, Theoret, Marc Robert, Beaver, Julia A., Pazdur, Richard

“…Abstract only 9606 Background: Higher PD-L1 score ≥ 50% predicts for greater benefit to immune checkpoint inhibitor (ICI) therapy in first line (1L) treatment…”
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European Registry on Helicobacter pylori management (Hp-EuReg): First-line Therapy in Israel by Boltin, Doron, Beniashvili, Zaza, Lahat, Adi, Hirsch, Jonathan, Nyssen, Olga P, Mégraud, Francis, O'Morain, Colm, Gisbert, Javier P, Niv, Yaron

“…The antibiotic resistance profile of Helicobacter pylori (H. pylori) is constantly changing. Up-to-date and reliable data for the effectiveness of first-line…”
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COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients by Stewart, Mark, Rodriguez-Watson, Carla, Albayrak, Adem, Asubonteng, Julius, Belli, Andrew, Brown, Thomas, Cho, Kelly, Das, Ritankar, Eldridge, Elizabeth, Gatto, Nicolle, Gelman, Alice, Gerlovin, Hanna, Goldberg, Stuart L, Hansen, Eric, Hirsch, Jonathan, Ho, Yuk-Lam, Ip, Andrew, Izano, Monika, Jones, Jason, Justice, Amy C, Klesh, Reyna, Kuranz, Seth, Lam, Carson, Mao, Qingqing, Mataraso, Samson, Mera, Robertino, Posner, Daniel C, Rassen, Jeremy A, Siefkas, Anna, Schrag, Andrew, Tourassi, Georgia, Weckstein, Andrew, Wolf, Frank, Bhat, Amar, Winckler, Susan, Sigal, Ellen V, Allen, Jeff

“…The COVID-19 pandemic remains a significant global threat. However, despite urgent need, there remains uncertainty surrounding best practices for…”
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Reportable actionability versus pragmatic actionability: Implementing precision medicine at three large health systems by Thompson, Michael A., Zaman, Ali, Winzeler, Alissa M, Kern, Jonathan, Ghosh, Aradhana, Hirsch, Jonathan, Godden, Jennifer, Weese, James Leighton, Singh, Maharaj, Eisenberg, Burton Larry, Demeure, Michael J., Haque, Nadia Z, Hoover, Spencer C., Kalkanis, Steven N.

“…Abstract only…”
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Successful automated normalization of cancer outcomes for half a million patients across four disparate health systems by Tittel, Paul D., Zaman, Ali, Shima, James E., Leal, David, Chen, James Lin, Ghosh, Aradhana, Hirsch, Jonathan, Trent, Jonathan C., Gordon, Bat-Ami, Cotta, Jared, Thompson, Michael A., Godden, Jennifer, Ruggeri, Antony, Weese, James Leighton, Haque, Nadia Z, Hoover, Spencer C., Kalkanis, Steven N.

“…Abstract only…”
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Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis by Nefussy, Beatrice, Hirsch, Jonathan, Cudkowicz, Merit E, Drory, Vivian E

“…Abstract Recently an association between statins and the onset and more rapid disease course of amyotrophic lateral sclerosis (ALS) was reported, while other…”
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Harnessing big data for precision medicine: A panel of experts elucidates the data challenges and proposes key strategic decisions points by Barash, Carol Isaacson, Elliston, Keith O., Andrew Faucett, W., Hirsch, Jonathan, Naik, Gauri, Rathjen, Alice, Wood, Grant

“…A group of disparate translational bioinformatics experts convened at the 6th Annual Precision Medicine Partnership Meeting, October 29–30, 2014 to discuss big…”
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