Search Results - "Hirsch, Joel A"

Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin by Sachyani, Dana, Dvir, Meidan, Strulovich, Roi, Tria, Giancarlo, Tobelaim, William, Peretz, Asher, Pongs, Olaf, Svergun, Dmitri, Attali, Bernard, Hirsch, Joel A.

“…Kv7 channels tune neuronal and cardiomyocyte excitability. In addition to the channel membrane domain, they also have a unique intracellular C-terminal (CT)…”
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Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin by Gomez-Llorente, Yacob, Jebara, Fady, Patra, Malay, Malik, Radhika, Nisemblat, Shahar, Chomsky-Hecht, Orna, Parnas, Avital, Azem, Abdussalam, Hirsch, Joel A., Ubarretxena-Belandia, Iban

“…mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the negative ATP binding inter-ring cooperativity of GroEL-GroES. Here we report the…”
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APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses by Fogel, Hilla, Frere, Samuel, Segev, Oshik, Bharill, Shashank, Shapira, Ilana, Gazit, Neta, O’Malley, Tiernan, Slomowitz, Edden, Berdichevsky, Yevgeny, Walsh, Dominic M., Isacoff, Ehud Y., Hirsch, Joel A., Slutsky, Inna

“…Accumulation of amyloid-β peptides (Aβ), the proteolytic products of the amyloid precursor protein (APP), induces a variety of synaptic dysfunctions ranging…”
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A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth by Hazak, Ora, Mamon, Elad, Lavy, Meirav, Sternberg, Hasana, Behera, Smrutisanjita, Schmitz-Thom, Ina, Bloch, Daria, Dementiev, Olga, Gutman, Itay, Danziger, Tomer, Schwarz, Netanel, Abuzeineh, Anas, Mockaitis, Keithanne, Estelle, Mark, Hirsch, Joel A, Kudla, Jörg, Yalovsky, Shaul

“…Signaling cross talks between auxin, a regulator of plant development, and Ca2+, a universal second messenger, have been proposed to modulate developmental…”
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Differential Interactions Between Beclin 1 and Bcl-2 Family Members by Erlich, Shlomit, Mizrachy, Liat, Segev, Oshik, Lindenboim, Liora, Zmira, Ofir, Adi-Harel, Sheli, Hirsch, Joel A., Stein, Reuven, Pinkas-Kramarski, Ronit

“…Autophagy, a cellular degradation system, promotes both cell death and survival. The interaction between Bcl-2 family proteins and Beclin 1, a Bcl-2…”
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Structural Flexibility of CaV1.2 and CaV2.2 I-II Proximal Linker Fragments in Solution by Almagor, Lior, Avinery, Ram, Hirsch, Joel A., Beck, Roy

“…Voltage-dependent calcium channels (CaV) enable the inward flow of calcium currents for a wide range of cells. CaV1 and CaV2 subtype α1 subunits form the…”
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The KCNQ1 (Kv7.1) COOH Terminus, a Multitiered Scaffold for Subunit Assembly and Protein Interaction by Wiener, Reuven, Haitin, Yoni, Shamgar, Liora, Fernández-Alonso, M. Carmen, Martos, Ariadna, Chomsky-Hecht, Orna, Rivas, Germán, Attali, Bernard, Hirsch, Joel A.

“…The Kv7 subfamily of voltage-dependent potassium channels, distinct from other subfamilies by dint of its large intracellular COOH terminus, acts to regulate…”
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The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis by Almagor, Lior, Chomsky-Hecht, Orna, Ben-Mocha, Adva, Hendin-Barak, Doran, Dascal, Nathan, Hirsch, Joel A

“…Voltage-dependent calcium channels (VDCCs) allow the passage of Ca(2+) ions through cellular membranes in response to membrane depolarization. The channel…”
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RGK Family G-Domain:GTP Analog Complex Structures and Nucleotide-Binding Properties by Sasson, Yehezkel, Navon-Perry, Leehee, Huppert, Dan, Hirsch, Joel A.

“…The RGK family of small G-proteins, including Rad, Gem, Rem1, and Rem2, is inducibly expressed in various mammalian tissues and interacts with…”
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A common Ca2+-driven interdomain module governs eukaryotic NCX regulation by Giladi, Moshe, Sasson, Yehezkel, Fang, Xianyang, Hiller, Reuben, Buki, Tal, Wang, Yun-Xing, Hirsch, Joel A, Khananshvili, Daniel

“…Na(+)/Ca(2+) exchanger (NCX) proteins mediate Ca(2+)-fluxes across the cell membrane to maintain Ca(2+) homeostasis in many cell types. Eukaryotic NCX contains…”
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Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split by Puhl, 3rd, Henry L, Lu, Van B, Won, Yu-Jin, Sasson, Yehezkel, Hirsch, Joel A, Ono, Fumihito, Ikeda, Stephen R

“…RGK proteins, Gem, Rad, Rem1, and Rem2, are members of the Ras superfamily of small GTP-binding proteins that interact with Ca2+ channel β subunits to modify…”
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Intracellular domains interactions and gated motions of IKS potassium channel subunits by Haitin, Yoni, Wiener, Reuven, Shaham, Dana, Peretz, Asher, Cohen, Enbal Ben-Tal, Shamgar, Liora, Pongs, Olaf, Hirsch, Joel A, Attali, Bernard

“…Voltage‐gated K + channels co‐assemble with auxiliary β subunits to form macromolecular complexes. In heart, assembly of Kv7.1 pore‐forming subunits with KCNE1…”
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The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome by Huttunen, Heta, Hero, Matti, Lääperi, Mitja, Känsäkoski, Johanna, Swan, Heikki, Hirsch, Joel A, Miettinen, Päivi J, Raivio, Taneli

“…Two missense mutations in , an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth…”
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Competitive and Non-competitive Regulation of Calcium-dependent Inactivation in CaV1.2 L-type Ca2+ Channels by Calmodulin and Ca2+-binding Protein 1 by Oz, Shimrit, Benmocha, Adva, Sasson, Yehezkel, Sachyani, Dana, Almagor, Lior, Lee, Amy, Hirsch, Joel A., Dascal, Nathan

“…CaV1.2 interacts with the Ca2+ sensor proteins, calmodulin (CaM) and calcium-binding protein 1 (CaBP1), via multiple, partially overlapping sites in the main…”
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Prosthodontic Considerations in Post-cancer Reconstructions by Boonsiriphant, Piriya, DDS, Hirsch, Joel A., DDS, Greenberg, Alex M., DDS, Genden, Eric M., MD, FACS

“…The restoration of function after oncologic surgery of the oral cavity constitutes one of the major challenges facing head and neck oncology. Within the…”
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Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms by Katz, Moshe, Subramaniam, Suraj, Chomsky-Hecht, Orna, Tsemakhovich, Vladimir, Flockerzi, Veit, Klussmann, Enno, Hirsch, Joel A., Weiss, Sharon, Dascal, Nathan

“…L-type voltage-gated CaV1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via…”
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Structural Insights into the M‑Channel Proximal C‑Terminus/Calmodulin Complex by Strulovich, Roi, Tobelaim, William Sam, Attali, Bernard, Hirsch, Joel A

“…The Kv7 (KCNQ) channel family, comprising voltage-gated potassium channels, plays major roles in fine-tuning cellular excitability by reducing firing frequency…”
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Transition of Arrestin into the Active Receptor-binding State Requires an Extended Interdomain Hinge by Vishnivetskiy, Sergey A, Hirsch, Joel A, Velez, Maria-Gabriela, Gurevich, Yulia V, Gurevich, Vsevolod V

“…Arrestins selectively bind to the phosphorylated activated form of G protein-coupled receptors, thereby blocking further G protein activation. Structurally,…”
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Reconstitution of β-adrenergic regulation of Ca V 1.2: Rad-dependent and Rad-independent protein kinase A mechanisms by Katz, Moshe, Subramaniam, Suraj, Chomsky-Hecht, Orna, Tsemakhovich, Vladimir, Flockerzi, Veit, Klussmann, Enno, Hirsch, Joel A, Weiss, Sharon, Dascal, Nathan

“…L-type voltage-gated Ca 1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via…”
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Structure of the multimodular endonuclease FokI bound to DNA by Wah, D A, Hirsch, J A, Dorner, L F, Schildkraut, I, Aggarwal, A K

“…FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance…”
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