Search Results - "Hirsch, Cassandra M"

Rational management approach to pure red cell aplasia by Balasubramanian, Suresh Kumar, Sadaps, Meena, Thota, Swapna, Aly, Mai, Przychodzen, Bartlomiej P, Hirsch, Cassandra M, Visconte, Valeria, Radivoyevitch, Tomas, Maciejewski, Jaroslaw P

“…Pure red cell aplasia is an orphan disease, and as such lacks rationally established standard therapies. Most cases are idiopathic; a subset is…”
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Molecular features of early onset adult myelodysplastic syndrome by Hirsch, Cassandra M, Przychodzen, Bartlomiej P, Radivoyevitch, Tomas, Patel, Bhumika, Thota, Swapna, Clemente, Michael J, Nagata, Yasunobu, LaFramboise, Thomas, Carraway, Hetty E, Nazha, Aziz, Sekeres, Mikkael A, Makishima, Hideki, Maciejewski, Jaroslaw P

“…Myelodysplastic syndromes are typically diseases of older adults. Patients in whom the onset is early may have distinct molecular and clinical features or…”
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Invariant phenotype and molecular association of biallelic TET2 mutant myeloid neoplasia by Awada, Hassan, Nagata, Yasunobu, Goyal, Abhinav, Asad, Mohammad F., Patel, Bhumika, Hirsch, Cassandra M., Kuzmanovic, Teodora, Guan, Yihong, Przychodzen, Bartlomiej P., Aly, Mai, Adema, Vera, Shen, Wenyi, Williams, Louis, Nazha, Aziz, Abazeed, Mohamed E., Sekeres, Mikkael A., Radivoyevitch, Tomas, Haferlach, Torsten, Jha, Babal K., Visconte, Valeria, Maciejewski, Jaroslaw P.

“…Somatic TET2 mutations (TET2MT) are frequent in myeloid neoplasia (MN), particularly chronic myelomonocytic leukemia (CMML). TET2MT includes mostly…”
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Consequences of mutant TET2 on clonality and subclonal hierarchy by Hirsch, Cassandra M., Nazha, Aziz, Kneen, Kassy, Abazeed, Mohamed E., Meggendorfer, Manja, Przychodzen, Bartlomiej P., Nadarajah, Niroshan, Adema, Vera, Nagata, Yasunobu, Goyal, Abhinav, Awada, Hassan, Asad, Mohammad Fahad, Visconte, Valeria, Guan, Yihong, Sekeres, Mikkael A., Olinski, Ryszard, Jha, Babal Kant, LaFramboise, Thomas, Radivoyevitch, Tomas, Haferlach, Torsten, Maciejewski, Jaroslaw P.

“…Somatic mutations in TET2 are common in myelodysplastic syndromes (MDS), myeloproliferative, and overlap syndromes. TET2 mutant ( TET2 MT ) clones are also…”
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Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria by Clemente, Michael J., Przychodzen, Bartlomiej, Hirsch, Cassandra M., Nagata, Yasunobu, Bat, Taha, Wlodarski, Marcin W., Radivoyevitch, Tomas, Makishima, Hideki, Maciejewski, Jaroslaw P.

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Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes by Nagata, Yasunobu, Narumi, Satoshi, Guan, Yihong, Przychodzen, Bartlomiej P., Hirsch, Cassandra M., Makishima, Hideki, Shima, Hirohito, Aly, Mai, Pastor, Victor, Kuzmanovic, Teodora, Radivoyevitch, Tomas, Adema, Vera, Awada, Hassan, Yoshida, Kenichi, Li, Samuel, Sole, Francesc, Hanna, Rabi, Jha, Babal K., LaFramboise, Thomas, Ogawa, Seishi, Sekeres, Mikkael A., Wlodarski, Marcin W., Cammenga, Jörg, Maciejewski, Jaroslaw P.

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BCOR and BCORL1 mutations in myelodysplastic syndromes (MDS): clonal architecture and impact on outcomes by Abuhadra, Nour, Mukherjee, Sudipto, Al-Issa, Karam, Adema, Vera, Hirsch, Cassandra M., Advani, Anjali, Przychodzen, Bartlomiej, Makhoul, Ahed, Awada, Hassan, Maciejewski, Jaroslaw P., Sekeres, Mikkael A., Nazha, Aziz

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Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones by Graham, Amy C, Efanov, Alexey, Przychodzen, Bartlomiej P., Hirsch, Cassandra M., Adema, Vera, Visconte, Valeria, Maciejewski, Jaroslaw P.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is usually associated with reduced bone marrow (BM) capacity caused by acquired idiopathic aplastic anemia (AA). PIGA…”
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Clonal Hierarchy of Piga Mutant Cells Assessed By Next Generation Sequencing Is More Complex Than Previously Recognized in Paroxysmal Noctural Hemoglobinuria by Clemente, Michael J., Przychodzen, Bartlomiej P, Hirsch, Cassandra M., Maciejewski, Jaroslaw P

“…Since the pivotal revelation of the PIGA gene mutations responsible for glycosylphosphatidylinositol (GPI) anchor deficiency over 20 years ago, molecular and…”
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Quantification of Erythroblast- and Myelocyte-Derived mRNAs in Plasma Exosomes As an Indicator of Bone Marrow Status in Patients with Various Types of Anemias and Myeloproliferative Disorders by Mitsuhashi, Masato, Murakami, Taku, Kuzmanovic, Teodora, Hirsch, Cassandra M., Makishima, Hideki, Maciejewski, Jaroslaw P

“…Introduction. Bone marrow (BM) aspiration is a routine test for hematologists, but it is a painful procedure for the patients. Since BM cells primarily stay in…”
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Heterozygous CTC1 Variants in Acquired Bone Marrow Failure by Shen, Wenyi, Hirsch, Cassandra M., Przychodzen, Bartlomiej P., Mahfouz, Reda Z., Radivoyevitch, Tomas, Williams, Louis, Asad, Mohammad Fahad B., Maciejewski, Jaroslaw P.

“…Germ line (GL) alterations of telomerase machinery genes may lead to inherited telomeropathies, but recent analysis of large control populations revealed that…”
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Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH) by Shen, Wenyi, Hirsch, Cassandra M., Przychodzen, Bartlomiej P., Makishima, Hideki, Williams, Louis, Mukherjee, Sudipto, Carraway, Hetty E., Sekeres, Mikkael A., Maciejewski, Jaroslaw P.

“…Next generation sequencing (NGS) methods, including whole exome sequencing (WES) and sequencing of large panels of genes have become standard tools…”
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Clinical and Biological Implications of CUX1 Mutations in Myeloid Neoplasms by Aly, Mai, Hosono, Naoko, Bartlomiej, Przychodzen, Makishima, Hideki, Yasunobu, Nagata, Hirsch, Cassandra M., Sekeres, Mikkael A., Maciejewski, Jaroslaw P.

“…Recurrent somatic mutations of CUX1 are described in myeloid neoplasms. CUX1 is located at chromosome 7q22.1; -7/del(7q) involving CUX1 locus are common…”
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Somatic PRPF8 Mutations in Myeloid Neoplasia by Adema, Vera, Hirsch, Cassandra M., Przychodzen, Bartlomiej P., Nagata, Yasunobu, Lemelle, Elise, Nazha, Aziz, Carraway, Hetty E., Sekeres, Mikkael A., Visconte, Valeria, Maciejewski, Jaroslaw P., Padgett, Richard A

“…Somaticmutations in genes of the RNA-splicing machinery are recurrent in myeloid neoplasia. PRPF8 has a central role in the spliceosome assembly and it is…”
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Paroxysmal Nocturnal Hemoglobinuria Results from Initial Clonal PIG-a Mosaicism by Clemente, Michael J., Przychodzen, Bartlomiej, Hirsch, Cassandra M., Patel, Bhumika J., Bat, Taha, Nagata, Yasunobu, Wlodarski, Marcin W., Makishima, Hideki, Maciejewski, Jaroslaw P.

“…The pathogenesis of PNH involves alteration of at least one HSC clone, characterized by a somatic mutation in the PIG-A gene. The resulting phenotype appears…”
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Clinical and Molecular Heterogeneity of Moderate Aplastic Anemia by Patel, Bhumika J., Barot, Shimoli Vipul, Kuzmanovic, Teodora, Przychodzen, Bartlomiej P., Hirsch, Cassandra M., Awada, Hassan, Hasipek, Metis, Thota, Swapna, Radivoyevitch, Tomas, Advani, Anjali S., Kalaycio, Matt, Sekeres, Mikkael A., Carraway, Hetty E., Maciejewski, Jaroslaw P.

“…Based on clinical Camitta criteria, acquired aplastic anemia is categorized according to the degree of blood count depression as severe (sAA) or moderate…”
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LUC7L2 Is a Novel RNA-Splicing Regulatory Factor Mutated in Myelodysplastic Syndromes by Hershberger, Courtney, Hiznay, James, Dietrich, Rosemary, Gu, Xiaorong, Hirsch, Cassandra M., Graham, Amy, Przychodzen, Bartlomiej P., Visconte, Valeria, Adema, Vera, Parker, Yvonne, Carraway, Hetty E., Radivoyevitch, Tomas, Sekeres, Mikkael A., Saunthararajah, Yogenthiran, Maciejewski, Jaroslaw P., Padgett, Richard A

“…Myelodysplastic syndromes (MDS) are unique among cancers because of the frequent occurrence of somatic mutations impacting spliceosome machinery. At least 65%…”
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Analysis of Even a Limited Number of Genes Indicates a Strong Inherited Component in Otherwise Typical Sporadic MDS by Hirsch, Cassandra M., Shen, Wenyi, Przychodzen, Bartlomiej P., Nagata, Yasunobu, Adema, Vera, Kuzmanovic, Teodora, Williams, Louis, Nazha, Aziz, Visconte, Valeria, Carraway, Hetty E., Sekeres, Mikkael A., Maciejewski, Jaroslaw P.

“…Somatic mutations are frequently found in patients with MDS. Germline (GL) alterations are less common, in part due to sequencing panels limited to mutations…”
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Genotype-Resultant Morphology of Myelodysplastic Syndromes (MDS) by Goyal, Abhinav, Mirzaev, Inom, Asad, Mohammad Fahad B., Awada, Hassan, Hirsch, Cassandra M., Makishima, Hideki, Yoshida, Kenichi, Przychodzen, Bartlomiej P., Nazha, Aziz, Mukherjee, Sudipto, Sekeres, Mikkael A., Ogawa, Seishi, Radivoyevitch, Tomas, Scott, Jacob, Maciejewski, Jaroslaw P., Nagata, Yasunobu

“…Morphology has dominated the diagnosis and classification of MDS for decades. With the advent of NGS, morphology is used as a gold standard to assess…”
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Distinct Implications of TP53 Hits for Patients with Treatment-Related MDS and AML by Kuzmanovic, Teodora, Patel, Bhumika J., Nagata, Yasunobu, Awada, Hassan, Hirsch, Cassandra M., Przychodzen, Bartlomiej P., Sanikommu, Srinivasa Reddy, Williams, Louis, Mukherjee, Sudipto, Advani, Anjali S., Nazha, Aziz, Gerds, Aaron T., Radivoyevitch, Tomas, Carraway, Hetty E., Sekeres, Mikkael A., Maciejewski, Jaroslaw P.

“…Background:TP53 is one of the most frequently mutated genes across all malignancies. Efforts to describe its role in Myeloid Neoplasms (MN) as well as Clonal…”
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