Search Results - "Hiroyasu, Sho"

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases by Hiroyasu, Sho, Zeglinski, Matthew R., Zhao, Hongyan, Pawluk, Megan A., Turner, Christopher T., Kasprick, Anika, Tateishi, Chiharu, Nishie, Wataru, Burleigh, Angela, Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Petersen, Frank, Crawford, Richard I., Shimizu, Hiroshi, Tsuruta, Daisuke, Ludwig, Ralf J., Granville, David J.

“…Pemphigoid diseases refer to a group of severe autoimmune skin blistering diseases characterized by subepidermal blistering and loss of dermal-epidermal…”
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Pathological functions of granzyme B in inflammatory skin diseases by Hiroyasu, Sho, Hiroyasu, Aoi, Granville, David J., Tsuruta, Daisuke

“…Dysregulated skin immunity is a hallmark of many skin diseases such as atopic dermatitis, autoimmune blistering diseases, and interface dermatitis. Current…”
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Case of pemphigoid nodularis with immunoglobulin (Ig)G deposition accompanied by postinflammatory hypopigmentation without IgG deposition on the same forearm by Hiroyasu, Sho, Hiroyasu, Aoi, Mine, Mako, Kotobuki, Yorihisa, Tsuruta, Daisuke

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Hereditary angioedema with normal C1 inhibitor with steroid responsiveness in a patient with psychiatric comorbidities by Barit, Jay‐V James, Hiroyasu, Sho, Terashima, Yurika, Ayano, Yuka, Tsuruta, Daisuke

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Malignant syphilis in a young immunocompetent patient presenting as ulceronecrotic lesions on the lower extremities by Barit, Jay‐V J., Hiroyasu, Sho, Yamada, Koichi, Tsuruta, Daisuke

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The pathological function of neutrophils in pemphigoid diseases by Matsumoto, Daisuke, Amatya, Beni, Tsuruta, Daisuke, Hiroyasu, Sho

“…Abstract Pemphigoid diseases (PDs) are a group of autoimmune blistering diseases, including bullous pemphigoid, epidermolysis bullosa acquisita, mucous…”
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Granzyme B as a therapeutic target for wound healing by Turner, Christopher T, Hiroyasu, Sho, Granville, David J

“…: Granzyme B is a serine protease traditionally understood as having a role in immune-mediated cytotoxicity. Over the past decade, this dogma has been…”
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Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage by Turner, Christopher T., Zeglinski, Matthew R., Richardson, Katlyn C., Santacruz, Stephanie, Hiroyasu, Sho, Wang, Christine, Zhao, Hongyan, Shen, Yue, Sehmi, Roma, Lima, Hermenio, Gauvreau, Gail M., Granville, David J.

“…Atopic dermatitis (AD) is the most common inflammatory skin condition. Skin barrier dysfunction is of major importance in AD because it facilitates allergen…”
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Pruritogens in pemphigoid diseases: Possible therapeutic targets for a burdensome symptom by Hiroyasu, Sho, Barit, Jay‐V James G., Hiroyasu, Aoi, Tsuruta, Daisuke

“…Pruritus is a hallmark feature in pemphigoid diseases, where it can be severe and greatly impact the quality of life of affected patients. Despite being a key…”
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Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins by Matsubara, Joanne A, Tian, Yuan, Cui, Jing Z, Zeglinski, Matthew R, Hiroyasu, Sho, Turner, Christopher T, Granville, David J

“…Granzymes are a family of serine proteases first shown to be intracellular initiators of immune-mediated cell death in target pathogenic cells. In addition to…”
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Proteases in Pemphigoid Diseases by Hiroyasu, Sho, Turner, Christopher T, Richardson, Katlyn C, Granville, David J

“…Pemphigoid diseases are a subgroup of autoimmune skin diseases characterized by widespread tense blisters. Standard of care typically involves…”
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Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation by Hiroyasu, Sho, Stimac, Gregory P, Hopkinson, Susan B, Jones, Jonathan C R

“…During healing of the skin, the cytoskeleton of keratinocytes and their matrix adhesions, including focal adhesions (FAs), undergo reorganization. These…”
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Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction by Russo, Valerio, Klein, Theo, Lim, Darielle J., Solis, Nestor, Machado, Yoan, Hiroyasu, Sho, Nabai, Layla, Shen, Yue, Zeglinski, Matthew R., Zhao, Hongyan, Oram, Cameron P., Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Crawford, Richard I., Franzke, Claus-Werner, Overall, Christopher M., Granville, David J.

“…In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity…”
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Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis by Richardson, Katlyn C, Aubert, Alexandre, Turner, Christopher T, Nabai, Layla, Hiroyasu, Sho, Pawluk, Megan A, Cederberg, Rachel A, Zhao, Hongyan, Jung, Karen, Burleigh, Angela, Crawford, Richard I, Granville, David J

“…Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces…”
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Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing by Shen, Yue, Zeglinski, Matthew R., Turner, Christopher T., Raithatha, Sheetal A., Wu, Zhenguo, Russo, Valerio, Oram, Cameron, Hiroyasu, Sho, Nabai, Layla, Zhao, Hongyan, Bozin, Tatjana, Westendorf, Kathryn, Kopko, Irina, Huang, Rachel, Arns, Steve, Tan, Jason, Zeng, Haishan, Boey, Anthony, Liggins, Richard, Jaquith, James, Cameron, Dale R., Papp, Anthony, Granville, David J.

“…Granzyme B (GzmB) is a serine protease that has long been thought to function exclusively in lymphocyte-mediated apoptosis. In recent years, this paradigm has…”
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The role of hemidesmosomes and focal contacts in the skin visualized by dual-color live cell imaging by Ozawa, Toshiyuki, Hiroyasu, Sho, Tsuruta, Daisuke

“…Live cell imaging is a powerful tool to elucidate dynamics of protein(s). Our group has concentrated on dynamics of two major cell-matrix adhesion devices,…”
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Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm by Imanishi, Akiko, Imanishi, Hisayoshi, Hiroyasu, Sho, Ozawa, Toshiyuki, Koga, Hiroshi, Ishii, Norito, Kitajima, Yasuo, Hashimoto, Takashi, Tsuruta, Daisuke

“…Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180 / collagen…”
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Stabilization of Hemidesmosomal Proteins: A Possible Key Contributor to Wnt/β-Catenin Pathway Action in the Skin by Hiroyasu, Sho, Tsuruta, Daisuke

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Concomitant occurrence of patch granuloma annulare and classical granuloma annulare by TSURUTA, Daisuke, SOWA, Junko, HIROYASU, Sho, ISHII, Masamitsu, KOBAYASHI, Hiromi

“…Granuloma annulare (GA) is characterized clinically as annularly‐distributed, erythematous papules on the extremities in children and adolescents. GA is…”
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Atypical erosive pustular dermatosis of the scalp with eosinophilia and erythroderma by HIROYASU, Sho, TSURUTA, Daisuke, YAMANE, Takahisa, SHIOI, Atsushi, TOYODA, Hiromitsu, ISHII, Masamitsu, KOBAYASHI, Hiromi

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