Search Results - "Hiroyama, Shuichi"

Evaluation of an Integrin αvβ3 Radiotracer, [18F]F-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver by Hiroyama, Shuichi, Matsunaga, Keiko, Ito, Miwa, Iimori, Hitoshi, Morita, Ippei, Nakamura, Jun, Shimosegawa, Eku, Abe, Kohji

“…Purpose Integrin α v is a key regulator in the pathophysiology of hepatic fibrosis. In this study, we evaluated the potential utility of an integrin α v β 3…”
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Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis by Hiroyama, Shuichi, Rokugawa, Takemi, Ito, Miwa, Iimori, Hitoshi, Morita, Ippei, Maeda, Hiroki, Fujisawa, Kae, Matsunaga, Keiko, Shimosegawa, Eku, Abe, Kohji

“…Background Integrin α v β 3 , which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the…”
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S-Nitrosylated Human Serum Albumin-mediated Cytoprotective Activity Is Enhanced by Fatty Acid Binding by Ishima, Yu, Akaike, Takaaki, Kragh-Hansen, Ulrich, Hiroyama, Shuichi, Sawa, Tomohiro, Suenaga, Ayaka, Maruyama, Toru, Kai, Toshiya, Otagiri, Masaki

“…Binding of oleate to S-nitrosylated human serum albumin (SNO-HSA) enhances its cytoprotective effect on liver cells in a rat ischemia/reperfusion model. It…”
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Usefulness of 18F-FPP-RGD2 PET in pathophysiological evaluation of lung fibrosis using a bleomycin-induced rat model by Hiroyama, Shuichi, Matsunaga, Keiko, Ito, Miwa, Iimori, Hitoshi, Tajiri, Minako, Nakano, Yoshiyuki, Shimosegawa, Eku, Abe, Kohji

“…Purpose Integrins α v are key molecules in the pathogenesis of fibrosis in multiple organs. To assess the potential utility of integrin α v β 3 imaging for…”
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The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia by Whiteside, Garth T, Kyle, Donald J, Kapil, Ram R, Cipriano, Alessandra, He, Ellie, Zhou, Mingyan, Shet, Manjunath S, Hummel, Michele, Knappenberger, Terri, Fukumura, Kazuya, Matsuo, Yoshiyuki, Uehira, Masahiro, Hiroyama, Shuichi, Takai, Nozomi, Willsie, Sandra K, Harris, Stephen C

“…Insomnia is a common disorder that poses a significant public health burden. Current treatments for insomnia primarily target aminobutyric acid or orexin…”
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The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia by Whiteside, Garth T, Kyle, Donald J, Kapil, Ram P, Cipriano, Alessandra, He, Ellie, Zhou, Mingyan, Shet, Manjunath S, Hummel, Michele, Knappenberger, Terri, Fukumura, Kazuya, Matsuo, Yoshiyuki, Uehira, Masahiro, Hiroyama, Shuichi, Takai, Nozomi, Willsie, Sandra K, Harris, Stephen C

“…The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia…”
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Evaluation of an Integrin α v β 3 Radiotracer, [ 18 F]F-FPP-RGD 2 , for Monitoring Pharmacological Effects of Integrin α v siRNA in the NASH Liver by Hiroyama, Shuichi, Matsunaga, Keiko, Ito, Miwa, Iimori, Hitoshi, Morita, Ippei, Nakamura, Jun, Shimosegawa, Eku, Abe, Kohji

“…Integrin α is a key regulator in the pathophysiology of hepatic fibrosis. In this study, we evaluated the potential utility of an integrin α β positron…”
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Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver by Hiroyama, Shuichi, Matsunaga, Keiko, Ito, Miwa, Iimori, Hitoshi, Morita, Ippei, Nakamura, Jun, Shimosegawa, Eku, Abe, Kohji

“…Integrin αv is a key regulator in the pathophysiology of hepatic fibrosis. In this study, we evaluated the potential utility of an integrin αvβ3 positron…”
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Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain by Fuchino, Kouki, Mitsuoka, Yasunori, Masui, Moriyasu, Kurose, Noriyuki, Yoshida, Shuhei, Komano, Kazuo, Yamamoto, Takahiko, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Miyajima, Hirofumi, Hiroyama, Shuichi, Koyabu, Kiyotaka, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi

“…Accumulation of Aβ peptides is a hallmark of Alzheimer’s disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key…”
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Usefulness of 18 F-FPP-RGD 2 PET in pathophysiological evaluation of lung fibrosis using a bleomycin-induced rat model by Hiroyama, Shuichi, Matsunaga, Keiko, Ito, Miwa, Iimori, Hitoshi, Tajiri, Minako, Nakano, Yoshiyuki, Shimosegawa, Eku, Abe, Kohji

“…Integrins α are key molecules in the pathogenesis of fibrosis in multiple organs. To assess the potential utility of integrin α β imaging for idiopathic…”
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Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models by Yokota, Tatsuya, Struzik, Zbigniew R., Jurica, Peter, Horiuchi, Masahito, Hiroyama, Shuichi, Li, Junhua, Takahara, Yuji, Ogawa, Koichi, Nishitomi, Kohei, Hasegawa, Minoru, Cichocki, Andrzej

“…We propose a novel semi-automatic approach to design biomarkers for capturing pharmacodynamic effects induced by pharmacological agents on the spectral power…”
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Combining behavior and EEG analysis for exploration of dynamic effects of ADHD treatment in animal models by Jurica, Peter, Struzik, Zbigniew R., Li, Junhua, Horiuchi, Masahito, Hiroyama, Shuichi, Takahara, Yuji, Nishitomi, Kohei, Ogawa, Koichi, Cichocki, Andrzej

“…•Activity from behavioral video recordings can be combined with EEG recordings.•Temporal dynamics of EEG features is analyzed by averaging of temporally…”
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Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice by Hiroyama, Shuichi, Horiuchi, Masahito, Abe, Kohji, Itoh, Tetsuji

“…Abstract Various stresses affect neuronal functions, including the onset and progression of seizures, in animals and humans of all ages. However, the effect of…”
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Effects of endogenous ligands on the biological role of human serum albumin in S-nitrosylation by Ishima, Yu, Akaike, Takaaki, Kragh-Hansen, Ulrich, Hiroyama, Shuichi, Sawa, Tomohiro, Maruyama, Toru, Kai, Toshiya, Otagiri, Masaki

“…Many proteins have been identified as targets for S-nitrosylation, including structural and signaling proteins, and ion channels. S-nitrosylation plays an…”
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One-step preparation of S-nitrosated human serum albumin with high biological activities by Ishima, Yu, Hiroyama, Shuichi, Kragh-Hansen, Ulrich, Maruyama, Toru, Sawa, Tomohiro, Akaike, Takaaki, Kai, Toshiya, Otagiri, Masaki

“…S-Nitrosated human serum albumin (SNO-HSA) is a large molecular weight nitric oxide carrier in human plasma, and because of its many beneficial effects in…”
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P081. Hepatic targeting system of S-nitrosylated human serum albumin enhanced by endogenous ligands binding by Ishima, Yu, Otagiri, Masaki, Hiroyama, Shuichi, Sawa, Tomohiro, Akaike, Takaaki

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