Search Results - "Hirota, Yasushi"

Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation by Hirota, Yasushi

“…Blastocyst implantation contains the following three processes: apposition, attachment, and invasion of the blastocyst. Ovarian hormone progesterone (P4)…”
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Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS by Azhary, Jerilee M K, Harada, Miyuki, Takahashi, Nozomi, Nose, Emi, Kunitomi, Chisato, Koike, Hiroshi, Hirata, Tetsuya, Hirota, Yasushi, Koga, Kaori, Wada-Hiraike, Osamu, Fujii, Tomoyuki, Osuga, Yutaka

“…Abstract Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and growth arrest of antral follicles. Previously, we found that endoplasmic…”
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Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M by Abe, Hajime, Takeda, Norihiko, Isagawa, Takayuki, Semba, Hiroaki, Nishimura, Satoshi, Morioka, Masaki Suimye, Nakagama, Yu, Sato, Tatsuyuki, Soma, Katsura, Koyama, Katsuhiro, Wake, Masaki, Katoh, Manami, Asagiri, Masataka, Neugent, Michael L., Kim, Jung-whan, Stockmann, Christian, Yonezawa, Tomo, Inuzuka, Ryo, Hirota, Yasushi, Maemura, Koji, Yamashita, Takeshi, Otsu, Kinya, Manabe, Ichiro, Nagai, Ryozo, Komuro, Issei

“…The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from the tissue microenvironment…”
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Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation by Fukui, Yamato, Hirota, Yasushi, Matsuo, Mitsunori, Gebril, Mona, Akaeda, Shun, Hiraoka, Takehiro, Osuga, Yutaka

“…Background Recurrent implantation failure is a critical issue in IVF‐ET treatment. Successful embryo implantation needs appropriate molecular and cellular…”
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Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations by Inoue, Satoshi, Hirota, Yasushi, Ueno, Toshihide, Fukui, Yamato, Yoshida, Emiko, Hayashi, Takuo, Kojima, Shinya, Takeyama, Reina, Hashimoto, Taiki, Kiyono, Tohru, Ikemura, Masako, Taguchi, Ayumi, Tanaka, Tomoki, Tanaka, Yosuke, Sakata, Seiji, Takeuchi, Kengo, Muraoka, Ayako, Osuka, Satoko, Saito, Tsuyoshi, Oda, Katsutoshi, Osuga, Yutaka, Terao, Yasuhisa, Kawazu, Masahito, Mano, Hiroyuki

“…Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features of…”
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Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models by Santoso, Erna G, Yoshida, Keita, Hirota, Yasushi, Aizawa, Masanori, Yoshino, Osamu, Kishida, Akio, Osuga, Yutaka, Saito, Shigeru, Ushida, Takashi, Furukawa, Katsuko S

“…Infertility caused by ovarian or tubal problems can be treated using In Vitro Fertilization and Embryo Transfer (IVF-ET); however, this is not possible for…”
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Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway by Takeuchi, Arisa, Koga, Kaori, Satake, Erina, Makabe, Tomoko, Taguchi, Ayumi, Miyashita, Mariko, Takamura, Masashi, Harada, Miyuki, Hirata, Tetsuya, Hirota, Yasushi, Yoshino, Osamu, Wada-Hiraike, Osamu, Fujii, Tomoyuki, Osuga, Yutaka

“…Abstract Context The ovarian reserve is reduced in patients with endometriosis. We hypothesize that the phosphatidylinositol 3-kinase (PI3K)-phosphatase and…”
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CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model by Ono, Yosuke, Yoshino, Osamu, Hiraoka, Takehiro, Sato, Erina, Furue, Akiko, Nawaz, Allah, Hatta, Hideki, Fukushi, Yoshiyuki, Wada, Shinichiro, Tobe, Kazuyuki, Hirota, Yasushi, Osuga, Yutaka, Unno, Nobuya, Saito, Shigeru

“…In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type…”
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Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis by Takahashi, Nozomi, Harada, Miyuki, Hirota, Yasushi, Nose, Emi, Azhary, Jerilee MK, Koike, Hiroshi, Kunitomi, Chisato, Yoshino, Osamu, Izumi, Gentaro, Hirata, Tetsuya, Koga, Kaori, Wada-Hiraike, Osamu, Chang, R. Jeffrey, Shimasaki, Shunichi, Fujii, Tomoyuki, Osuga, Yutaka

“…Recent studies report the involvement of intra-ovarian factors, such as inflammation and oxidative stress, in the pathophysiology of polycystic ovary syndrome…”
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Androgens Increase Accumulation of Advanced Glycation End Products in Granulosa Cells by Activating ER Stress in PCOS by Azhary, Jerilee M K, Harada, Miyuki, Kunitomi, Chisato, Kusamoto, Akari, Takahashi, Nozomi, Nose, Emi, Oi, Nagisa, Wada-Hiraike, Osamu, Urata, Yoko, Hirata, Tetsuya, Hirota, Yasushi, Koga, Kaori, Fujii, Tomoyuki, Osuga, Yutaka

“…Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, and we previously found that androgens activate endoplasmic reticulum (ER) stress in…”
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Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch by Kim, Jeonghyun, Ushida, Takashi, Montagne, Kevin, Hirota, Yasushi, Yoshino, Osamu, Hiraoka, Takehiro, Osuga, Yutaka, Furuakwa, Katsuko S.

“…The uterus plays an important and unique role during pregnancy and is a dynamic organ subjected to mechanical stimuli. It has been reported that infertility…”
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Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice by Hirota, Yasushi, Cha, Jeeyeon, Yoshie, Mikihiro, Daikoku, Takiko, Dey, Sudhansu K

“…Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human…”
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Prediction of the final menstrual period in women taking Dienogest using estradiol and follicle-stimulating hormone values: a case-control study by Uehara, Mari, Wada-Hiraike, Osamu, Koga, Kaori, Yamamoto, Naoko, Hirano, Mana, Harada, Miyuki, Hirota, Yasushi, Osuga, Yutaka

“…Dienogest (DNG) is widely used to treat dysmenorrhea associated with estrogen-dependent diseases such as endometriosis and adenomyosis. DNG becomes unnecessary…”
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Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity by Daikoku, Takiko, Cha, Jeeyeon, Sun, Xiaofei, Tranguch, Susanne, Xie, Huirong, Fujita, Tomoko, Hirota, Yasushi, Lydon, John, DeMayo, Francesco, Maxson, Robert, Dey, Sudhansu K.

“…An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction…”
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Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis by Miyashita, Mariko, Koga, Kaori, Izumi, Gentaro, Sue, Fusako, Makabe, Tomoko, Taguchi, Ayumi, Nagai, Miwako, Urata, Yoko, Takamura, Masashi, Harada, Miyuki, Hirata, Tetsuya, Hirota, Yasushi, Wada-Hiraike, Osamu, Fujii, Tomoyuki, Osuga, Yutaka

“…Context: Endometriosis is an estrogen-dependent, chronic inflammatory disease. Recent studies have shown that vitamin D (VD) is an effective modulator of the…”
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Uterine prostaglandin DP receptor-induced upon implantation contributes to decidualization together with EP4 receptor by Sakamoto, Risa, Fujiwara, Takuji, Kawano, Yuko, Aikawa, Shizu, Inazumi, Tomoaki, Nakayama, On, Kawasaki-Shirata, Yukiko, Hashimoto-Iwasaki, Miho, Sugimoto, Toshiko, Tsuchiya, Soken, Nakao, Satohiro, Takeo, Toru, Hirota, Yasushi, Sugimoto, Yukihiko

“…To investigate the yet-unknown roles of prostaglandins (PGs) in the uterus, we analyzed the expression of various PG receptors in the uterus. We found that…”
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F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus by Egashira, Mahiro, Hirota, Yasushi, Shimizu-Hirota, Ryoko, Saito-Fujita, Tomoko, Haraguchi, Hirofumi, Matsumoto, Leona, Matsuo, Mitsunori, Hiraoka, Takehiro, Tanaka, Tomoki, Akaeda, Shun, Takehisa, Chiaki, Saito-Kanatani, Mayuko, Maeda, Kei-ichiro, Fujii, Tomoyuki, Osuga, Yutaka

“…Cellular senescence, defined as an irreversible cell cycle arrest, exacerbates the tissue microenvironment. Our previous study demonstrated that mouse uterine…”
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Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis by Izumi, Gentaro, Ph.D., M.D, Koga, Kaori, Ph.D., M.D, Takamura, Masashi, Ph.D., M.D, Makabe, Tomoko, M.D, Nagai, Miwako, Ph.D., M.D, Urata, Yoko, Ph.D., M.D, Harada, Miyuki, Ph.D., M.D, Hirata, Tetsuya, Ph.D., M.D, Hirota, Yasushi, Ph.D., M.D, Fujii, Tomoyuki, Ph.D., M.D, Osuga, Yutaka, Ph.D., M.D

“…Objectives To characterize peritoneal dendritic cells (DCs) in endometriosis and to clarify their role in its etiology. Design Experimental. Setting University…”
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Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention by Deng, Wenbo, Yuan, Jia, Cha, Jeeyeon, Sun, Xiaofei, Bartos, Amanda, Yagita, Hideo, Hirota, Yasushi, Dey, Sudhansu K.

“…Preterm birth (PTB) is a syndrome with many origins. Among them, infection or inflammation are major risk factors for PTB; however, local defense mechanisms to…”
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Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females by Hiraoka, Takehiro, Hirota, Yasushi, Aikawa, Shizu, Iida, Rei, Ishizawa, Chihiro, Kaku, Tetsuaki, Hirata, Tomoyuki, Fukui, Yamato, Akaeda, Shun, Matsuo, Mitsunori, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Osuga, Yutaka

“…Adenomyosis is a benign uterine disease that causes dysmenorrhea, heavy menstrual bleeding, and infertility; however, its pathophysiology remains unclear…”
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