Search Results - "Hirota, Kosaku"

Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity by Ikawa, Takashi, Sajiki, Hironao, Hirota, Kosaku

“…A palladium–fibroin complex (Pd/Fib) was prepared by soaking silk-fibroin in MeOH solution of Pd(OAc) 2 for 2 days (under Ar atmosphere)—4 days (under air)…”
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Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent by Sajiki, Hironao, Ikawa, Takashi, Hirota, Kosaku

“…A selective and catalytic mono-N-alkylation method of both aromatic and aliphatic amines using nitriles as an alkylating agent with Pd/C or Rh/C as a catalyst…”
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Aromatic ring favorable and efficient H–D exchange reaction catalyzed by Pt/C by Sajiki, Hironao, Ito, Nobuhiro, Esaki, Hiroyoshi, Maesawa, Tsuneaki, Maegawa, Tomohiro, Hirota, Kosaku

“…An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five…”
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Efficient C−H/C−D Exchange Reaction on the Alkyl Side Chain of Aromatic Compounds Using Heterogeneous Pd/C in D2O by Sajiki, Hironao, Aoki, Fumiyo, Esaki, Hiroyoshi, Maegawa, Tomohiro, Hirota, Kosaku

“…An efficient and extensive deuterium incorporation using heterogeneous Pd/C−D2O−H2 system into many different types of unactivated C−H bond positions was…”
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Chemoselective control of hydrogenation among aromatic carbonyl and benzyl alcohol derivatives using Pd/C(en) catalyst by Hattori, Kazuyuki, Sajiki, Hironao, Hirota, Kosaku

“…The hydrogenolysis of aromatic ketones and aldehydes quite smoothly give the corresponding methylene compounds via the formation of the intermediary benzyl…”
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DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats by Miyazaki, Shin, Yanagida, Takashi, Nunome, Kana, Ishikawa, Shizuma, Inden, Masatoshi, Kitamura, Yoshihisa, Nakagawa, Shinsuke, Taira, Takahiro, Hirota, Kosaku, Niwa, Masami, Iguchi-Ariga, Sanae M.M, Ariga, Hiroyoshi

“…Parkinson's disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors of dopamine degradation have been used for PD…”
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Mild and general procedure for Pd/C-catalyzed hydrodechlorination of aromatic chlorides by Sajiki, Hironao, Kume, Akira, Hattori, Kazuyuki, Hirota, Kosaku

“…A mild and efficient one-pot hydrodechlorination using a Pd/C–Et 3N system proceeds at room temperature, which is general for the dechlorination of a variety…”
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The Formation of a Novel Pd/C−Ethylenediamine Complex Catalyst:  Chemoselective Hydrogenation without Deprotection of the O-Benzyl and N-Cbz Groups by Sajiki, Hironao, Hattori, Kazuyuki, Hirota, Kosaku

“…A Pd/C catalyst formed an isolable complex with ethylenediamine employed as the catalytic poison via one-to-one interaction between Pd metal and…”
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Unexpected deprotection of silyl and THP ethers induced by serious disparity in the quality of Pd/C catalysts and elucidation of the mechanism by Ikawa, Takashi, Sajiki, Hironao, Hirota, Kosaku

“…Commercial Pd/C catalysts show different catalytic activity toward the deprotection of silyl and THP ethers. The Pd/C purchased from Merck and ACROS exhibits…”
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Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH4OAc by Sajiki, Hironao, Mori, Akinori, Mizusaki, Tomoteru, Ikawa, Takashi, Maegawa, Tomohiro, Hirota, Kosaku

“…A Pd/C-catalyzed deoxygenation method of phenolic hydroxyl groups via aryl triflates or mesylates using Mg metal in MeOH at room temperature was developed. The…”
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Solvent-modulated Pd/C-catalyzed deprotection of silyl ethers and chemoselective hydrogenation by Ikawa, Takashi, Hattori, Kazuyuki, Sajiki, Hironao, Hirota, Kosaku

“…Recently we have reported undesirable and frequent deprotection of the TBDMS protective group of a variety of hydroxyl functions occurred under neutral and…”
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Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of a Phenolic MPM Protective Group Using Pyridine as a Catalyst Poison by Sajiki, Hironao, Hirota, Kosaku

“…Employment of a Pd/C–pyridine combination as a catalyst is a very useful method for the selective removal (hydrogenolysis) of phenolic O-benzyl, N-Cbz and…”
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Complete Replacement of H2 by D2 via Pd/C-Catalyzed H/D Exchange Reaction by Sajiki, Hironao, Kurita, Takanori, Esaki, Hiroyoshi, Aoki, Fumiyo, Maegawa, Tomohiro, Hirota, Kosaku

“…A general and in situ D2 gas generation method using 10% Pd/C-catalyzed H2−D2 exchange reaction in a H2−D2O system has been developed. H2 gas sealed in a…”
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Development of diversified methods for chemical modification of the 5,6-double bond of uracil derivatives depending on active methylene compounds by Sajiki, Hironao, Iida, Yusuke, Ikawa, Kanoko, Sawama, Yoshinari, Monguchi, Yasunari, Kitade, Yukio, Maki, Yoshifumi, Inoue, Hideo, Hirota, Kosaku

“…The reaction of 5-halogenouracil and uridine derivatives 1 and 7 with active methylene compounds under basic conditions produced diverse and selective C-C bond…”
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Preparation of silk fibroin-supported Pd(0) catalyst for chemoselective hydrogenation: reduction of palladium(II) acetate by methanol on the protein by Sajiki, Hironao, Ikawa, Takashi, Yamada, Hiromi, Tsubouchi, Kozo, Hirota, Kosaku

“…The Pd/fibroin (Fib) was easily prepared by the auto-reduction of the silk-fibroin conjugated Pd(OAc) 2 using MeOH as a solvent and a reductant and exhibited…”
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Undesirable deprotection of O-TBDMS groups by Pd/C-catalyzed hydrogenation and chemoselective hydrogenation using a Pd/C(en) catalyst by Hattori, Kazuyuki, Sajiki, Hironao, Hirota, Kosaku

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Complete and truly catalytic degradation method of PCBs using Pd/C–Et3N system under ambient pressure and temperature by Sajiki, Hironao, Kume, Akira, Hattori, Kazuyuki, Nagase, Hisamistu, Hirota, Kosaku

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Iodobenzene Diacetate–Promoted N–N and N–O Bond Formation for Pyrazolo- and Isoxazolopyrimidine Syntheses by Sajiki, Hironao, Monguchi, Yasunari, Hattori, Kazuyuki, Maegawa, Tomohiro, Hirota, Kosaku

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The undesirable lability of tert-butyldimethylsilyl ethers under Pd/C-catalyzed hydrogenation conditions and solution of the problem by using a Pd/C(en) catalyst by Hattori, Kazuyuki, Sajiki, Hironao, Hirota, Kosaku

“…While the frequent and unexpected loss of the TBDMS protective group of a variety of hydroxylic functions was demonstrated under neutral and mild hydrogenation…”
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Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: Discovery of 8-mercaptoadenines as potent interferon-inducers by HIROTA, Kosaku, KAZAOKA, Kazunori, SAJIKI, Hironao

“…Recently, we have identified 9-benzyl-8-hydroxyadenines bearing an appropriate substituent (a butoxy, propylthio or butylamino group) at the 2-position as…”
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