Search Results - "Hirota, Christina L"

TRPM8 activation attenuates inflammatory responses in mouse models of colitis by Ramachandran, Rithwik, Hyun, Eric, Zhao, Liena, Lapointe, Tamia K., Chapman, Kevin, Hirota, Christina L., Ghosh, Subrata, McKemy, David D., Vergnolle, Nathalie, Beck, Paul L., Altier, Christophe, Hollenberg, Morley D.

“…Transient Receptor Potential Melastatin–8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated…”
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Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells by Iablokov, Vadim, Hirota, Christina L., Peplowski, Michael A., Ramachandran, Rithwik, Mihara, Koichiro, Hollenberg, Morley D., MacNaughton, Wallace K.

“…Mucosal biopsies from inflamed colon of inflammatory bowel disease patients exhibit elevated epithelial apoptosis compared with those from healthy individuals,…”
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Constitutive androstane receptor regulates the intestinal mucosal response to injury by Hudson, Grace M, Flannigan, Kyle L, Erickson, Sarah L, Vicentini, Fernando A, Zamponi, Alexandra, Hirota, Christina L, Alston, Laurie, Altier, Christophe, Ghosh, Subrata, Rioux, Kevin P, Mani, Sridhar, Chang, Thomas K, Hirota, Simon A

“…Background and Purpose The pathogenesis of the inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), involves…”
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Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation by Wang, Hongying, Moreau, France, Hirota, Christina L, MacNaughton, Wallace K

“…Proteinase-activated receptors (PARs) are involved in both inflammation and tumorigenesis in epithelial cells. Interleukin (IL)-8 is a potent chemoattractant…”
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Neutralizing Anti-IL-10 Antibody Blocks the Protective Effect of Tapeworm Infection in a Murine Model of Chemically Induced Colitis by Hunter, Meaghan M, Wang, Arthur, Hirota, Christina L, McKay, Derek M

“…There is increasing evidence that parasitic helminth infection has the ability to ameliorate other disease conditions. In this study the ability of the rat…”
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Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation by Dicay, Michael S, Hirota, Christina L, Ronaghan, Natalie J, Peplowski, Michael A, Zaheer, Raza S, Carati, Colin A, MacNaughton, Wallace K

“…Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that…”
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Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells by Hirota, Christina L, Moreau, France, Iablokov, Vadim, Dicay, Michael, Renaux, Bernard, Hollenberg, Morley D, MacNaughton, Wallace K

“…Proteinase-activated receptor (PAR)(2), a G protein-coupled receptor activated by serine proteinases, has been implicated in both intestinal inflammation and…”
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The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells by Hollenberg, Morley D., Hirota, Christina L., Buret, Andre G., Jijon, Humberto B., Beck, Paul L.

“…TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8…”
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Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2 by van der Merwe, Jacques Q, Ohland, Christina L, Hirota, Christina L, MacNaughton, Wallace K

“…Proteinase-activated receptor (PAR)(2) is activated by trypsin-like serine proteinases and has been implicated in intestinal inflammation. However, its role in…”
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M3 muscarinic receptor-deficient mice retain bethanechol-mediated intestinal ion transport and are more sensitive to colitis by Hirota, Christina L, McKay, Derek M

“…Acetylcholine (ACh) is an important regulator of intestinal epithelial ion transport via muscarinic or nicotinic ACh receptors. Previous studies emphasize the…”
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Loss of Ca2+‐mediated ion transport during colitis correlates with reduced ion transport responses to a Ca2+‐activated K+ channel opener by Hirota, Christina L., McKay, Derek M.

“…Background and purpose:  Epithelial surface hydration is critical for proper gut function. However, colonic tissues from individuals with inflammatory bowel…”
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Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener by Hirota, Christina L, McKay, Derek M

“…Epithelial surface hydration is critical for proper gut function. However, colonic tissues from individuals with inflammatory bowel disease or animals with…”
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Tu1825 Protease-Activated Receptor 2 Exerts a Tonic Anti-Apoptotic Effect in HT-29 Colonic Epithelial Cells by Iablokov, Vadim, Hirota, Christina L, MacNaughton, Wallace K

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M1828 Metalloproteinase Activity and Epidermal Growth Factor Receptor Transactivation are Required for PAR2 -Induced COX-2 Expression in CACO-2 Cells by Hirota, Christina L, Moreau, France, MacNaughton, Wallace K

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S1694 Protease-Activated Receptor-2 Reduces TNFα-Induced Apoptosis in Colonic Epithelial Cells by Iablokov, Vadim, Hirota, Christina L, MacNaughton, Wallace K

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959 Protease-Activated Receptors (PARS) 1 and 2 Stimulate Interleukin (IL)-8 Expression in HT-29 Cells via ERK/RSK90, Non-Classical NfκB Activation and Histone Acetylation by Wang, Hongying, Moreau, France, Hirota, Christina L, MacNaughton, Wallace K

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Sa1877 Decreased TGF-ß1 Secretion From Monocyte-Derived Dendritic Cells is Associated With Higher Frequency of IL-17 Secreting FOXP3+ CD4+ T Cells in Peripheral Blood From Inflammatory Bowel Disease Patients by Ueno, Aito, Jijon, Humberto, Lam, Victor, Poon, Karen K, Hirota, Christina L, Ford, Kim, Rabbani, Ida, Kaplan, Gilaad G, Panaccione, Remo, Beck, Paul L, Barkema, Herman, Sigalet, David L, Ghosh, Subrata

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M1796 TGF-Alpha Autocrine Signaling is a Key Step in TNF-Alpha-Stimulated Proinflammatory Signaling in Intestinal Epithelial Cells by Jijon, Humberto, Buret, Andre G, Hirota, Christina L, Hollenberg, Morley D, Beck, Paul L

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Interferon-[gamma] Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation by Dicay, Michael S, Hirota, Christina L, Ronaghan, Natalie J, Peplowski, Michael A, Zaheer, Raza S, Carati, Colin A, MacNaughton, Wallace K

“…Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that…”
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Loss of Ca 2+ ‐mediated ion transport during colitis correlates with reduced ion transport responses to a Ca 2+ ‐activated K + channel opener by Hirota, Christina L., McKay, Derek M.

“…Background and purpose:  Epithelial surface hydration is critical for proper gut function. However, colonic tissues from individuals with inflammatory bowel…”
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