Search Results - "Hirota, A"

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter by Hirota, Jeremy A., PhD, Hirota, Simon A., PhD, Warner, Stephanie M., BSc, Stefanowicz, Dorota, BSc, Shaheen, Furquan, BSc, Beck, Paul L., MD, PhD, MacDonald, Justin A., PhD, Hackett, Tillie-Louise, PhD, Sin, Don D., MD, Van Eeden, Stephan, MD, Knight, Darryl A., PhD

“…Background The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory…”
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Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia by Vicentini, Fernando A, Keenan, Catherine M, Wallace, Laurie E, Woods, Crystal, Cavin, Jean-Baptiste, Flockton, Amanda R, Macklin, Wendy B, Belkind-Gerson, Jaime, Hirota, Simon A, Sharkey, Keith A

“…The intestinal microbiota plays an important role in regulating gastrointestinal (GI) physiology in part through interactions with the enteric nervous system…”
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Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue by Aguiar, Jennifer A, Tremblay, Benjamin J-M, Mansfield, Michael J, Woody, Owen, Lobb, Briallen, Banerjee, Arinjay, Chandiramohan, Abiram, Tiessen, Nicholas, Cao, Quynh, Dvorkin-Gheva, Anna, Revill, Spencer, Miller, Matthew S, Carlsten, Christopher, Organ, Louise, Joseph, Chitra, John, Alison, Hanson, Paul, Austin, Richard C, McManus, Bruce M, Jenkins, Gisli, Mossman, Karen, Ask, Kjetil, Doxey, Andrew C, Hirota, Jeremy A

“…In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the…”
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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation by McDonald, Braedon, Pittman, Keir, Menezes, Gustavo B, Hirota, Simon A, Slaba, Ingrid, Waterhouse, Christopher C.M, Beck, Paul L, Muruve, Daniel A, Kubes, Paul

“…Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using…”
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Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota by Nieves, Kristoff M, Hirota, Simon A, Flannigan, Kyle L

“…The commensal bacteria that reside in the gastrointestinal tract exist in a symbiotic relationship with the host, driving the development of the immune system…”
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Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 by Banerjee, Arinjay, Nasir, Jalees A, Budylowski, Patrick, Yip, Lily, Aftanas, Patryk, Christie, Natasha, Ghalami, Ayoob, Baid, Kaushal, Raphenya, Amogelang R, Hirota, Jeremy A, Miller, Matthew S, McGeer, Allison J, Ostrowski, Mario, Kozak, Robert A, McArthur, Andrew G, Mossman, Karen, Mubareka, Samira

“…Since its emergence in Wuhan, China, in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected ≈6 million persons worldwide…”
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TNF-α and Poly(I:C) induction of A20 and activation of NF-κB signaling are independent of ABCF1 in human airway epithelial cells by Cao, Quynh T., Ishak, Mira, Shpilman, Israel, Hirota, Jeremy A.

“…ABCF1 is the most characterized member of the ABCF family in eukaryotes with proposed functions related to innate immunity in fibroblasts, macrophages, and…”
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Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis by Gulbransen, Brian D, Bashashati, Mohammad, Hirota, Simon A, Gui, Xianyong, Roberts, Jane A, MacDonald, Justin A, Muruve, Daniel A, McKay, Derek M, Beck, Paul L, Mawe, Gary M, Thompson, Roger J, Sharkey, Keith A

“…Enteric neuron death is linked to the pathogenesis of inflammatory bowel disease. Now, Brian Gulbransen and his colleagues demonstrate that P2X7…”
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Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma by Hansbro, Philip M., Kim, Richard Y., Starkey, Malcolm R., Donovan, Chantal, Dua, Kamal, Mayall, Jemma R., Liu, Gang, Hansbro, Nicole G., Simpson, Jodie L., Wood, Lisa G., Hirota, Jeremy A., Knight, Darryl A., Foster, Paul S., Horvat, Jay C.

“…Summary Severe, steroid‐resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid…”
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Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation by Garg, Aditya, Zhao, Angela, Erickson, Sarah L, Mukherjee, Subhajit, Lau, Aik Jiang, Alston, Laurie, Chang, Thomas K H, Mani, Sridhar, Hirota, Simon A

“…The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with a complex etiology. IBD is thought to arise in genetically susceptible…”
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Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress by El-Daly, Mahmoud, Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Kang, Sean, Fedak, Paul W.M., Alston, Laurie A., Hirota, Simon A., Ding, Hong, Triggle, Chris R., Hollenberg, Morley D.

“…Hyperglycaemia is a major contributor to diabetic cardiovascular disease with hyperglycaemia-induced endothelial dysfunction recognized as the initiating…”
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Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis by Terc, Joshua, Hansen, Ashleigh, Alston, Laurie, Hirota, Simon A.

“…[Display omitted] The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the gastrointestinal tract. Barrier dysfunction…”
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Understanding the Molecular Mechanisms of Rifaximin in the Treatment of Gastrointestinal Disorders--A Focus on the Modulation of Host Tissue Function by Hirota, Simon A

“…Rifaximin is a broad-spectrum oral antibiotic, exhibiting limited systemic absorption, that is used clinically to treat a variety of gastrointestinal…”
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Auxin-Regulated AP2/EREBP Gene PUCHI Is Required for Morphogenesis in the Early Lateral Root Primordium of Arabidopsis by Hirota, Atsuko, Kato, Takehide, Fukaki, Hidehiro, Aida, Mitsuhiro, Tasaka, Masao

“…Organ primordia develop from founder cells into organs due to coordinated patterns of cell division. How patterned cell division is regulated during organ…”
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Star Formation Efficiencies at Giant Molecular Cloud Scales in the Molecular Disk of the Elliptical Galaxy NGC 5128 (Centaurus A) by Espada, D., Verley, S., Miura, R. E., Israel, F. P., Henkel, C., Matsushita, S., Vila-Vilaro, B., Ott, J., Morokuma-Matsui, K., Peck, A. B., Hirota, A., Aalto, S., Quillen, A. C., Hogerheijde, M. R., Neumayer, N., Vlahakis, C., Iono, D., Kohno, K.

“…We present ALMA CO (1−0) observations toward the dust lane of the nearest elliptical and radio galaxy, NGC 5128 (Centaurus A), with high angular resolution…”
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NLRP3 deficiency exacerbates enterovirus infection in mice by Wang, Chen, Fung, Gabriel, Deng, Haoyu, Jagdeo, Julienne, Mohamud, Yasir, Xue, Yuan Chao, Jan, Eric, Hirota, Jeremy A., Luo, Honglin

“…ABSTRACT The role for the NOD‐like receptor (NLR) P3 inflammasome in enterovirus infection remains controversial. Available data suggest that the NLRP3…”
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Human airway epithelial cell innate immunity: relevance to asthma by Hirota, Jeremy A, Knight, Darryl A

“…Highlights ► The airway epithelium is an integral component of the innate immune system. ► Airway epithelial cells detect environmental insults and initiate…”
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3D Bioprinting Strategies, Challenges, and Opportunities to Model the Lung Tissue Microenvironment and Its Function by Barreiro Carpio, Mabel, Dabaghi, Mohammadhossein, Ungureanu, Julia, Kolb, Martin R, Hirota, Jeremy A, Moran-Mirabal, Jose Manuel

“…Human lungs are organs with an intricate hierarchical structure and complex composition; lungs also present heterogeneous mechanical properties that impose…”
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Observing the Sun with the Atacama Large Millimeter/submillimeter Array (ALMA): Fast-Scan Single-Dish Mapping by White, S. M., Iwai, K., Phillips, N. M., Hills, R. E., Hirota, A., Yagoubov, P., Siringo, G., Shimojo, M., Bastian, T. S., Hales, A. S., Sawada, T., Asayama, S., Sugimoto, M., Marson, R. G., Kawasaki, W., Muller, E., Nakazato, T., Sugimoto, K., Brajša, R., Skokić, I., Bárta, M., Kim, S., Remijan, A. J., de Gregorio, I., Corder, S. A., Hudson, H. S., Loukitcheva, M., Chen, B., De Pontieu, B., Fleishmann, G. D., Gary, D. E., Kobelski, A., Wedemeyer, S., Yan, Y.

“…The Atacama Large Millimeter/submillimeter Array (ALMA) radio telescope has commenced science observations of the Sun starting in late 2016. Since the Sun is…”
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Surface Modification of PDMS-Based Microfluidic Devices with Collagen Using Polydopamine as a Spacer to Enhance Primary Human Bronchial Epithelial Cell Adhesion by Dabaghi, Mohammadhossein, Shahriari, Shadi, Saraei, Neda, Da, Kevin, Chandiramohan, Abiram, Selvaganapathy, Ponnambalam Ravi, Hirota, Jeremy A

“…Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency,…”
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