Search Results - "Hiroshi Yagi"

Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen by Ogawa, Yurina, Masugi, Yohei, Abe, Tokiya, Yamazaki, Ken, Ueno, Akihisa, Fujii-Nishimura, Yoko, Hori, Shutaro, Yagi, Hiroshi, Abe, Yuta, Kitago, Minoru, Sakamoto, Michiie

“…Cancer-associated fibroblasts have emerged to be highly heterogenous and can play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC)…”
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Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments by Kurebayashi, Yutaka, Matsuda, Kosuke, Ueno, Akihisa, Tsujikawa, Hanako, Yamazaki, Ken, Masugi, Yohei, Kwa, Wit Thun, Effendi, Kathryn, Hasegawa, Yasushi, Yagi, Hiroshi, Abe, Yuta, Kitago, Minoru, Ojima, Hidenori, Sakamoto, Michiie

“…Background and Aims Immune cells and tumor vessels constitute important elements in tumor tissue; however, their detailed relationship in human tumors,…”
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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix by Uygun, Korkut, Uygun, Basak E, Soto-Gutierrez, Alejandro, Yagi, Hiroshi, Izamis, Maria-Louisa, Guzzardi, Maria A, Shulman, Carley, Milwid, Jack, Kobayashi, Naoya, Tilles, Arno, Berthiaume, Francois, Hertl, Martin, Nahmias, Yaakov, Yarmush, Martin L

“…A critical donor organ shortage currently limits the treatment of patients with severe liver failure. Building on earlier work with decellularized hearts,…”
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Decellularized liver scaffolds promote liver regeneration after partial hepatectomy by Shimoda, Hirofumi, Yagi, Hiroshi, Higashi, Hisanobu, Tajima, Kazuki, Kuroda, Kohei, Abe, Yuta, Kitago, Minoru, Shinoda, Masahiro, Kitagawa, Yuko

“…The resectable liver volume is strictly limited and this reduces the number of patients who may be treated. Recently, “tissue/organ decellularization”, a new…”
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KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study by Nakano, Yutaka, Kitago, Minoru, Matsuda, Sachiko, Nakamura, Yuki, Fujita, Yusuke, Imai, Shunichi, Shinoda, Masahiro, Yagi, Hiroshi, Abe, Yuta, Hibi, Taizo, Fujii-Nishimura, Yoko, Takeuchi, Ayano, Endo, Yutaka, Itano, Osamu, Kitagawa, Yuko

“…Background: Pancreatic ductal adenocarcinoma (PDAC) has very poor prognosis despite existing multimodal therapies. This study aimed to investigate whether KRAS…”
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Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis by Fujita, Yusuke, Matsuda, Sachiko, Sasaki, Yasushi, Masugi, Yohei, Kitago, Minoru, Yagi, Hiroshi, Abe, Yuta, Shinoda, Masahiro, Tokino, Takashi, Sakamoto, Michiie, Kitagawa, Yuko

“…There are increased opportunities in oncology clinics to identify multiple pancreatic ductal adenocarcinomas (PDAC) that co‐occur simultaneously or arise…”
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Mesenchymal stem cells: Mechanisms of immunomodulation and homing by Yagi, Hiroshi, Soto-Gutierrez, Alejandro, Parekkadan, Biju, Kitagawa, Yuko, Tompkins, Ronald G, Kobayashi, Naoya, Yarmush, Martin L

“…Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissue. A growing corpus of studies have highlighted…”
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A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig by Nishi, Kotaro, Yagi, Hiroshi, Ohtomo, Mana, Nagata, Shogo, Udagawa, Daisuke, Tsuchida, Tomonori, Morisaku, Toshinori, Kitagawa, Yuko

“…Drug-induced liver fibrosis models are used in normal and immunosuppressed small animals for transplantation and regenerative medicine to improve liver…”
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Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds by Koria, Piyush, Yagi, Hiroshi, Kitagawa, Yuko, Megeed, Zaki, Nahmias, Yaakov, Sheridan, Robert, Yarmush, Martin L., Langer, Robert

“…Chronic wounds are associated with poor epidermal and dermal remodeling. Previous work has shown the efficacy of keratinocyte growth factor (KGF) in…”
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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells by Takeishi, Kazuki, Collin de l’Hortet, Alexandra, Wang, Yang, Handa, Kan, Guzman-Lepe, Jorge, Matsubara, Kentaro, Morita, Kazutoyo, Jang, Sae, Haep, Nils, Florentino, Rodrigo M., Yuan, Fangchao, Fukumitsu, Ken, Tobita, Kimimasa, Sun, Wendell, Franks, Jonathan, Delgado, Evan R., Shapiro, Erik M., Fraunhoffer, Nicolas A., Duncan, Andrew W., Yagi, Hiroshi, Mashimo, Tomoji, Fox, Ira J., Soto-Gutierrez, Alejandro

“…The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a…”
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Combination of KRAS and SMAD4 mutations in formalin‐fixed paraffin‐embedded tissues as a biomarker for pancreatic cancer by Yokose, Takahiro, Kitago, Minoru, Matsuda, Sachiko, Sasaki, Yasushi, Masugi, Yohei, Nakamura, Yuki, Shinoda, Masahiro, Yagi, Hiroshi, Abe, Yuta, Oshima, Go, Hori, Shutaro, Yusuke, Fujita, Nakano, Yutaka, Endo, Yutaka, Abe, Kodai, Tokino, Takashi, Kitagawa, Yuko

“…Formalin‐fixed paraffin‐embedded (FFPE) tissues used for routine pathological diagnosis are valuable for cancer genomic analysis; however, the association…”
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Construction of sinusoid-scale microvessels in perfusion culture of a decellularized liver by Watanabe, Masafumi, Yano, Koki, Okawa, Koki, Yamashita, Tadahiro, Tajima, Kazuki, Sawada, Kazuaki, Yagi, Hiroshi, Kitagawa, Yuko, Tanishita, Kazuo, Sudo, Ryo

“…[Display omitted] There is a great deal of demand for the construction of transplantable liver grafts. Over the last decade, decellularization techniques have…”
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Injectable extracellular matrix hydrogels contribute to native cell infiltration in a rat partial nephrectomy model by Kushige, Hiroko, Amano, Yuki, Yagi, Hiroshi, Morisaku, Toshinori, Kojima, Hideaki, Satou, Akiko, Hamada, Ken‐ichi, Kitagawa, Yuko

“…Decellularized extracellular matrix (dECM) hydrogels have cytocompatibility, and are currently being investigated for application in soft tissues as a material…”
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Novel approach for reconstruction of the three-dimensional biliary system in decellularized liver scaffold using hepatocyte progenitors by Hirukawa, Kazuya, Yagi, Hiroshi, Kuroda, Kohei, Watanabe, Masafumi, Nishi, Kotaro, Nagata, Shogo, Abe, Yuta, Kitago, Minoru, Adachi, Shungo, Sudo, Ryo, Kitagawa, Yuko

“…Reconstruction of the biliary system is indispensable for the regeneration of transplantable liver grafts. Here, we report the establishment of the first…”
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Molecular diagnosis for detecting KRAS mutation in peritoneal washing fluid of pancreatic ductal adenocarcinoma by Shimane, Gaku, Nakano, Yutaka, Matsuda, Sachiko, Kitago, Minoru, Masugi, Yohei, Nakamura, Kohei, Nakamura, Yuki, Yagi, Hiroshi, Abe, Yuta, Hasegawa, Yasushi, Hori, Shutaro, Tanaka, Masayuki, Takemura, Ryo, Nishihara, Hiroshi, Kitagawa, Yuko

“…Positive peritoneal washing cytology is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC); however, its sensitivity is…”
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The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure by Mizota, Takamasa, Hishiki, Takako, Shinoda, Masahiro, Naito, Yoshiko, Hirukawa, Kazuya, Masugi, Yohei, Itano, Osamu, Obara, Hideaki, Kitago, Minoru, Yagi, Hiroshi, Abe, Yuta, Matsubara, Kentaro, Suematsu, Makoto, Kitagawa, Yuko

“…The liver has been thought to protect against oxidative stress through mechanisms involving reduced glutathione (GSH) that consumes high-energy…”
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Adipose-Derived Mesenchymal Stromal/Stem Cell Line Prevents Hepatic Ischemia/Reperfusion Injury in Rats by Inhibiting Inflammasome Activation by Chen, Kaili, Obara, Hideaki, Matsubara, Yumiko, Fukuda, Kazumasa, Yagi, Hiroshi, Ono-Uruga, Yukako, Matsubara, Kentaro, Kitagawa, Yuko

“…Mesenchymal stromal/stem cells (MSCs) have shown potential in the treatment of degenerative diseases, including ischemia/reperfusion injury (IRI), which occurs…”
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FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors by Kitade, Shoko, Onoyama, Ichiro, Kobayashi, Hiroaki, Yagi, Hiroshi, Yoshida, Sachiko, Kato, Masaya, Tsunematsu, Ryosuke, Asanoma, Kazuo, Sonoda, Kenzo, Wake, Norio, Hata, Kenichiro, Nakayama, Keiichi I., Kato, Kiyoko

“…FBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c‐Myc, cyclin E, Notch and c‐Jun. FBXW7 is a known tumor‐suppressor gene, and…”
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Human-scale whole-organ bioengineering for liver transplantation: a regenerative medicine approach by Yagi, Hiroshi, Fukumitsu, Ken, Fukuda, Kazumasa, Kitago, Minoru, Shinoda, Masahiro, Obara, Hideaki, Itano, Osamu, Kawachi, Shigeyuki, Tanabe, Minoru, Coudriet, Gina M, Piganelli, Jon D, Gilbert, Thomas W, Soto-Gutierrez, Alejandro, Kitagawa, Yuko

“…At this time, the only definitive treatment of hepatic failure is liver transplantation. However, transplantation has been limited by the severely limited…”
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Extrahepatic approach for taping the common trunk of the middle and left hepatic veins or the left hepatic vein alone in laparoscopic hepatectomy (with videos) by Nakano, Yutaka, Abe, Yuta, Kitago, Minoru, Yagi, Hiroshi, Hasegawa, Yasushi, Hori, Shutaro, Koizumi, Wataru, Ojima, Hidenori, Imanishi, Nobuaki, Kitagawa, Yuko

“…Background Outflow control is difficult, and techniques required for effectively handling intraoperative hemorrhage during laparoscopic hepatectomy have not…”
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