Search Results - "Hiroshi Sudo"

Triterpene Functional Genomics in Licorice for Identification of CYP72A154 Involved in the Biosynthesis of Glycyrrhizin by Seki, Hikaru, Sawai, Satoru, Ohyama, Kiyoshi, Mizutani, Masaharu, Ohnishi, Toshiyuki, Sudo, Hiroshi, Fukushima, Ery Odette, Akashi, Tomoyoshi, Aoki, Toshio, Saito, Kazuki, Muranaka, Toshiya

“…Glycyrrhizin, a triterpenoid saponin derived from the underground parts of Glycyrrhiza plants (licorice), has several pharmacological activities and is also…”
Get full text

Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin by Seki, Hikaru, Ohyama, Kiyoshi, Sawai, Satoru, Mizutani, Masaharu, Ohnishi, Toshiyuki, Sudo, Hiroshi, Akashi, Tomoyoshi, Aoki, Toshio, Saito, Kazuki, Muranaka, Toshiya

“…Glycyrrhizin, a major bioactive compound derived from the underground parts of Glycyrrhiza (licorice) plants, is a triterpene saponin that possesses a wide…”
Get full text

Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis by Nakabayashi, Ryo, Hashimoto, Kei, Mori, Tetsuya, Toyooka, Kiminori, Sudo, Hiroshi, Saito, Kazuki

“…Spatial metabolomics uses imaging mass spectrometry (IMS) to localize metabolites within tissue section. Here, we performed matrix-assisted laser…”
Get full text

Allylic Hydroxylation Activity Is a Source of Saponin Chemodiversity in the Genus Glycyrrhiza by Fanani, Much Z, Sawai, Satoru, Seki, Hikaru, Ishimori, Masato, Ohyama, Kiyoshi, Fukushima, Ery O, Sudo, Hiroshi, Saito, Kazuki, Muranaka, Toshiya

“…Licorice (Glycyrrhiza) produces glycyrrhizin, a valuable triterpenoid saponin, which exhibits persistent sweetness and broad pharmacological activities. In the…”
Get full text

Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila by Asano, Takashi, Kobayashi, Kanae, Kashihara, Emi, Sudo, Hiroshi, Sasaki, Ryosuke, Iijima, Yoko, Aoki, Koh, Shibata, Daisuke, Saito, Kazuki, Yamazaki, Mami

“…Secondary metabolic flux was modified in the hairy roots of Ophiorrhiza pumila using RNAi technology to produce camptothecin, an anti-neoplastic monoterpenoid…”
Get full text

Producing the sulfur-containing metabolite asparaptine in Asparagus calluses and a suspension cell line by Nakabayashi, Ryo, Nishizawa, Tomoko, Mori, Tetsuya, Sudo, Hiroshi, Fujii, Isao, Asano, Takashi, Saito, Kazuki

“…Asparaptine, a conjugate of L-arginine and asparagusic acid, was found in green asparagus (Asparagus officinalis) using ultrahigh-resolution metabolomics for…”
Get full text

Molecular Basis of C-30 Product Regioselectivity of Legume Oxidases Involved in High-Value Triterpenoid Biosynthesis by Fanani, Much Zaenal, Fukushima, Ery Odette, Sawai, Satoru, Tang, Jianwei, Ishimori, Masato, Sudo, Hiroshi, Ohyama, Kiyoshi, Seki, Hikaru, Saito, Kazuki, Muranaka, Toshiya

“…The triterpenes are structurally diverse group of specialized metabolites with important roles in plant defense and human health. Glycyrrhizin, with a carboxyl…”
Get full text

Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations by Sirikantaramas, Supaart, Meeprasert, Arthitaya, Rungrotmongkol, Thanyada, Fuji, Hideyoshi, Hoshino, Tyuji, Sudo, Hiroshi, Yamazaki, Mami, Saito, Kazuki

“…A significant difference in the linker domain orientation between camptothecin (CPT) –resistant and –sensitive topoisomerase I (Top1) leads to the…”
Get full text

Camptothecin: therapeutic potential and biotechnology by Sirikantaramas, Supaart, Asano, Takashi, Sudo, Hiroshi, Yamazaki, Mami, Saito, Kazuki

“…Camptothecin (CPT) and its derivatives have been received considerable attention recently. Two semi-synthetic derivatives, topotecan and irinotecan, are…”
Get more information

Transport of camptothecin in hairy roots of Ophiorrhiza pumila by Sirikantaramas, Supaart, Sudo, Hiroshi, Asano, Takashi, Yamazaki, Mami, Saito, Kazuki

“…Autofluorescence emitted from camptothecin, an anticancer monoterpene indole alkaloid, in the hairy root of Ophiorrhiza pumila suggests its localization in the…”
Get full text

Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: Cloning, characterization and differential expression in tissues and by stress compounds by Yamazaki, Y. (Chiba Univ. (Japan)), Sudo, H, Yamazaki, M, Aimi, N, Saito, K

“…Camptothecin derivatives are clinically used antitumor compounds that biogenetically belong to a group of monoterpenoid indole alkaloids (TIA). We have already…”
Get full text

Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species by Asano, Takashi, Sudo, Hiroshi, Yamazaki, Mami, Saito, Kazuki

“…Camptothecin derivatives are clinically used for the treatment of various human cancers. These derivatives are semi-synthesized from camptothecin which is…”
Get more information

Biosynthesis of Camptothecin. In Silico and in vivo Tracer Study from [1-13C]Glucose by Yasuyo Yamazaki, Mariko Kitajima, Arita, Masanori, Takayama, Hiromitsu, Hiroshi Sudo, Yamazaki, Mami, Aimi, Norio, Saito, Kazuki

“…Camptothecin derivatives are clinically used antitumor alkaloids that belong to monoterpenoid indole alkaloids. In this study, we investigated the biosynthetic…”
Get full text

Biosynthetic system of camptothecin: An anticancer plant product by Yamazaki, Mami, Asano, Takashi, Yamazaki, Yasuyo, Sirikantaramas, Supaart, Sudo, Hiroshi, Saito, Kazuki

“…Camptothecin is one of the clinically used anticancer compounds derived from plants. We have established a hairy root culture , which efficiently produces…”
Get full text

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants by Yamazaki, Yasuyo, Urano, Akiko, Sudo, Hiroshi, Kitajima, Mariko, Takayama, Hiromitsu, Yamazaki, Mami, Aimi, Norio, Saito, Kazuki

“…Camptothecin derivatives are clinically used anti-neoplastic alkaloids that biogenetically belong to monoterpenoid indole alkaloids. Camptothecin-related…”
Get full text

Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis by Kitajima, Mariko, Fujii, Norie, Yoshino, Fumie, Sudo, Hiroshi, Saito, Kazuki, Aimi, Norio, Takayama, Hiromitsu

“…Two new monoterpene glucosides, demethylsecologanol and 3′′′-O-glucosylsenburiside II, were isolated from Ophiorrhiza liukiuensis (Rubiaceae) together with 23…”
Get full text

Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila by SUDO, Hiroshi, YAMAKAWA, Takashi, YAMAZAKI, Mami, AIMI, Norio, SAITO, Kazuki

“…A large-scale culture of hairy root of Ophiorrhiza pumila using a modified 3 l bioreactor was established. The hairy roots, incited by infection of…”
Get full text

Tropane Alkaloid Production and Shoot Regeneration in Hairy and Adventitious Root Cultures of Duboisia myoporoides–D. leichhardtii Hybrid by Yoshimatsu, Kayo, Sudo, Hiroshi, Kamada, Hiroshi, Kiuchi, Fumiyuki, Kikuchi, Yutaka, Sawada, Jun-ichi, Shimomura, Koichiro

“…Co-culture conditions for Duboisia myoporoides–D. leichhardtii hybrid hairy root induction were investigated using leaf explants and Agrobacterium rhizogenes…”
Get full text

Functional specialization of UDP‐glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin by Nomura, Yuhta, Seki, Hikaru, Suzuki, Tomonori, Ohyama, Kiyoshi, Mizutani, Masaharu, Kaku, Tomomi, Tamura, Keita, Ono, Eiichiro, Horikawa, Manabu, Sudo, Hiroshi, Hayashi, Hiroaki, Saito, Kazuki, Muranaka, Toshiya

“…Summary Glycyrrhizin, a sweet triterpenoid saponin found in the roots and stolons of Glycyrrhiza species (licorice), is an important active ingredient in…”
Get full text

Anti-TIF1-γ Antibody-Positive Dermatomyositis Leading to Identification of Diffuse Large B-Cell Lymphoma by Otsuki, Takuya, Ishizuka, Kosuke, Eto, Hiromitsu, Nakano, Hiroyasu, Kato, Yo, Sudo, Hiroshi, Motohashi, Iori, Ie, Kenya, Ohira, Yoshiyuki, Okuse, Chiaki

Get full text