Search Results - "Hiroshi Seno"

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells by Basak, Onur, Beumer, Joep, Wiebrands, Kay, Seno, Hiroshi, van Oudenaarden, Alexander, Clevers, Hans

“…Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing…”
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Non–clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell‐derived anti–glypican‐3 chimeric antigen receptor‐expressing natural killer/innate lymphoid cells by Ueda, Tatsuki, Kumagai, Ayako, Iriguchi, Shoichi, Yasui, Yutaka, Miyasaka, Tadayo, Nakagoshi, Kengo, Nakane, Kazuki, Saito, Keigo, Takahashi, Mari, Sasaki, Aki, Yoshida, Shinsuke, Takasu, Naoko, Seno, Hiroshi, Uemura, Yasushi, Tamada, Koji, Nakatsura, Tetsuya, Kaneko, Shin

“…The use of allogeneic, pluripotent stem‐cell‐derived immune cells for cancer immunotherapy has been the subject of recent clinical trials. In Japan,…”
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Does immune checkpoint inhibitor exhibit limited efficacy against non‐viral hepatocellular carcinoma?: A review of clinical trials by Eso, Yuji, Taura, Kojiro, Seno, Hiroshi

“…Immunotherapy with immune checkpoint inhibitors has been shown to be beneficial for cancers originating from various organs. In May 2020, combination therapy…”
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Mapping biopsy for bile duct cancer using a novel device delivery system by Matsumori, Tomoaki, Uza, Norimitsu, Shiokawa, Masahiro, Maruno, Takahisa, Kuwada, Takeshi, Marui, Saiko, Seno, Hiroshi

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Rapid Progression of a Sessile Serrated Lesion by Hiramatsu, Yukiko, Utsumi, Takahiro, Ikeda, Munehiro, Seno, Hiroshi

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Synergistic effects of anti-angiogenesis and immune checkpoint blockade - a new era of systemic chemotherapy for hepatocellular carcinoma by Eso, Yuji, Seno, Hiroshi

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Validation of Intraoperative Catheter Phase Mapping Using a Simultaneous Optical Measurement System in Rabbit Ventricular Myocardium by Tomii, Naoki, Asano, Keisuke, Seno, Hiroshi, Ashihara, Takashi, Sakuma, Ichiro, Yamazaki, Masatoshi

“…Background:Recently, an interoperative catheter electrode mapping system, termed ExTRa Mapping (EXT), was developed for precise diagnosis and effective…”
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Current status of treatment with immune checkpoint inhibitors for gastrointestinal, hepatobiliary, and pancreatic cancers by Eso, Yuji, Seno, Hiroshi

“…The development of immune checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), or…”
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The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system by Nagao, Munemasa, Fukuda, Akihisa, Seno, Hiroshi

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SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2 by Masuo, Kenji, Chen, Ru, Yogo, Akitada, Sugiyama, Aiko, Fukuda, Akihisa, Masui, Toshihiko, Uemoto, Shinji, Seno, Hiroshi, Takaishi, Shigeo

“…Pancreatic cancer has an extremely poor prognosis because of its resistance to conventional therapies. Cancer stem cell (CSC)‐targeted therapy is considered a…”
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Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling by Takada, Yutaka, Fukuda, Akihisa, Chiba, Tsutomu, Seno, Hiroshi

“…Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, is essential for development and homeostasis of various organs. However, the functional role…”
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Identification of modules and functional analysis in CRC subtypes by integrated bioinformatics analysis by Chen, Ru, Sugiyama, Aiko, Seno, Hiroshi, Sugimoto, Masahiro

“…Colorectal cancer is one of the top three causes of cancer-related mortality globally, but no predictive molecular biomarkers are currently available for…”
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Interinstitutional differences in diagnosis of the morphology of colorectal polyps in Japan: a nationwide database analysis by Utsumi, Takahiro, Horimatsu, Takahiro, Nishikawa, Yoshitaka, Seno, Hiroshi

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The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma by Tsuda, Motoyuki, Fukuda, Akihisa, Kawai, Munenori, Araki, Osamu, Seno, Hiroshi

“…ATP‐dependent chromatin remodeling complexes are a group of epigenetic regulators that can alter the assembly of nucleosomes and regulate the accessibility of…”
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Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology by Sogabe, Yuko, Seno, Hiroshi, Yamamoto, Takuya, Yamada, Yasuhiro

“…Reprogramming technology has enabled the fate conversion of terminally differentiated somatic cells into pluripotent stem cells or into another differentiated…”
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Lineage tracing and targeting of IL17RB⁺ tuft cell-like human colorectal cancer stem cells by Goto, Norihiro, Fukuda, Akihisa, Yamaga, Yuichi, Yoshikawa, Takaaki, Maruno, Takahisa, Maekawa, Hisatsugu, Inamoto, Susumu, Kawada, Kenji, Sakai, Yoshiharu, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Chiba, Tsutomu, Seno, Hiroshi

“…Cancer stem cell (CSC)-specific markers may be potential therapeutic targets. We previously identified that Dclk1, a tuft cell marker, marks tumor stem cells…”
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Recent Advances in Immunotherapy for Hepatocellular Carcinoma by Nakano, Shigeharu, Eso, Yuji, Okada, Hirokazu, Takai, Atsushi, Takahashi, Ken, Seno, Hiroshi

“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since most patients are diagnosed at advanced stage and the current…”
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Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis by Kim, Soo Ki, Takeda, Haruhiko, Takai, Atsushi, Matsumoto, Tomonori, Kakiuchi, Nobuyuki, Yokoyama, Akira, Yoshida, Kenichi, Kaido, Toshimi, Uemoto, Shinji, Minamiguchi, Sachiko, Haga, Hironori, Shiraishi, Yuichi, Miyano, Satoru, Seno, Hiroshi, Ogawa, Seishi, Marusawa, Hiroyuki

“…Background Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological…”
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Cardiac macrophages prevent sudden death during heart stress by Sugita, Junichi, Fujiu, Katsuhito, Nakayama, Yukiteru, Matsubara, Takumi, Matsuda, Jun, Oshima, Tsukasa, Liu, Yuxiang, Maru, Yujin, Hasumi, Eriko, Kojima, Toshiya, Seno, Hiroshi, Asano, Keisuke, Ishijima, Ayumu, Tomii, Naoki, Yamazaki, Masatoshi, Kudo, Fujimi, Sakuma, Ichiro, Nagai, Ryozo, Manabe, Ichiro, Komuro, Issei

“…Cardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet medical need. Because right ventricular (RV) dysfunction increases the…”
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Warning from artificial intelligence against inaccurate polyp size estimation by Utsumi, Takahiro, Horimatsu, Takahiro, Sano, Yasushi, Seno, Hiroshi

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