Search Results - "Hiroshi, Shiono"

Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Konishi, Hiroaki, Fujiya, Mikihiro, Okuda, Katsuhiro, Asari, Masaru, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…Background Colchicine binds to intracellular tubulin and prevents mitosis. Colchicine is also used as an anti-inflammatory drug. Meanwhile, excess…”
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Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Okuda, Katsuhiro, Asari, Masaru, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…Background Hypothermia, either therapeutically induced or accidental (ie, an involuntary decrease in core body temperature to <35°C), results in hemostatic…”
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Assessment of DNA degradation of buccal cells under humid conditions and DNA repair by DOP-PCR using locked nucleic acids by Asari, Masaru, Matsuura, Hiroaki, Isozaki, Shotaro, Hoshina, Chisato, Okuda, Katsuhiro, Tanaka, Hiroki, Horioka, Kie, Shiono, Hiroshi, Shimizu, Keiko

“…•The effect of humid conditions was evaluated based on two degradation ratios.•At 25 °C, the humidity significantly decreased 129:41- and 305:41-bp ratios…”
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Multidirectional analysis for a colchicine poisoning case revealed detail cause of death and its mechanism by Okuda, Katsuhiro, Isozaki, Shotaro, Asari, Masaru, Tanaka, Hiroki, Horioka, Kie, Takahashi, Yuta, Hoshina, Chisato, Yamada, Hiromi, Mori, Kanae, Namba, Ryo, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…•Tissue distribution of colchicine in humans died of acute colchicine poisoning.•Genetic analysis of stomach contents to reveal ingestion of Meadow…”
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Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Thiosulfate in Human Blood and Urine as an Indicator of Hydrogen Sulfide Poisoning by Maseda, Chikatoshi, Hayakawa, Akira, Okuda, Katsuhiro, Asari, Masaru, Tanaka, Hiroki, Yamada, Hiromi, Jin, Shigeki, Horioka, Kie, Matoba, Kotaro, Shiono, Hiroshi, Matsubara, Kazuo, Shimizu, Keiko

“…Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide…”
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Discrimination of haplotype in mitochondrial DNA mixtures using LNA-mediated PCR clamping by Asari, Masaru, Isozaki, Shotaro, Hoshina, Chisato, Okuda, Katsuhiro, Tanaka, Hiroki, Horioka, Kie, Shiono, Hiroshi, Shimizu, Keiko

“…•We developed a discrimination method of mtDNA mixtures by PCR clamping using LNA.•The specificity of LNA-containing probes was evaluated by predicting Tm…”
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Multicolor-based discrimination of 21 short tandem repeats and amelogenin using four fluorescent universal primers by Asari, Masaru, Okuda, Katsuhiro, Hoshina, Chisato, Omura, Tomohiro, Tasaki, Yoshikazu, Shiono, Hiroshi, Matsubara, Kazuo, Shimizu, Keiko

“…The aim of this study was to develop a cost-effective genotyping method using high-quality DNA for human identification. A total of 21 short tandem repeats…”
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An objective approach using three indexes for determining fatal hypothermia due to cold exposure; statistical analysis of oxyhemoglobin saturation data by Yajima, Daisuke, Asari, Masaru, Okuda, Katsuhiro, Maseda, Chikatoshi, Yamada, Hiromi, Ichimaru, Chisato, Matsubara, Kazuo, Shiono, Hiroshi, Iwase, Hirotaro, Makino, Yosuke, Shimizu, Keiko

“…Graphical abstract Scatter plots of hypothermia (●) and control (□) cases, with L-O2 Hb (oxyhemoglobin (O2 -Hb) saturation levels in left heart blood) and L–R…”
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Chained nuclei and python pattern in skeletal muscle cells as histological markers for electrical injury by Tanaka, Hiroki, Okuda, Katsuhiro, Ohtani, Seiji, Asari, Masaru, Horioka, Kie, Isozaki, Shotaro, Hayakawa, Akira, Ogawa, Katsuhiro, Hiroshi, Shiono, Shimizu, Keiko

“…•Python pattern and chained nuclear change are uniquely observed in the skeletal muscle of patients with electrical injury.•The python pattern was induced by…”
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Universal fluorescent labeling of amplification products using locked nucleic acids by Asari, Masaru, Oka, Kumiko, Omura, Tomohiro, Maseda, Chikatoshi, Tasaki, Yoshikazu, Shiono, Hiroshi, Matsubara, Kazuo, Matsuda, Mitsuyoshi, Shimizu, Keiko

“…Amplification/hybridization‐based genetic analyses using primers containing locked nucleic acids (LNAs) present many benefits. Here, we developed a novel…”
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Postmortem diffusion of n -butane and i -butane used for anticontagious plugging spray by Okuda, Katsuhiro, Maseda, Chikatoshi, Asari, Masaru, Isozaki, Shotaro, Kiya, Hiroshi, Yajima, Daisuke, Shiono, Hiroshi, Shimizu, Keiko

“…Highlights • A man died of multiple head traumas due to a fall from a moving vehicle. • Blood and tissue samples of the man contained certain amounts of…”
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Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture by Shimizu, Keiko, Matsubara, Kazuo, Ohtaki, Ko-ichi, Shiono, Hiroshi

“…Paraquat (1,1′-dimethyl-4,4′-bipyridinium, PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between…”
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An autopsy case of sudden death due to acute gastric dilatation without rupture by Watanabe, Satoshi, Terazawa, Koichi, Asari, Masaru, Matsubara, Kazuo, Shiono, Hiroshi, Shimizu, Keiko

“…Abstract We report the first autopsy case of fatal gastric dilatation without rupture. A 31-year-old woman who lived alone was found dead in her living room…”
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Multiplex PCR-based Alu insertion polymorphisms genotyping for identifying individuals of Japanese ethnicity by Asari, Masaru, Omura, Tomohiro, Oka, Kumiko, Maseda, Chikatoshi, Tasaki, Yoshikazu, Shiono, Hiroshi, Matsubara, Kazuo, Matsuda, Mitsuyoshi, Shimizu, Keiko

“…Discrimination of Alu insertions is a useful tool for geographic ancestry analysis, and is usually performed by Alu element amplification and agarose gel…”
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Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases by Aoyama, Koji, Matsubara, Kazuo, Fujikawa, Yasunori, Nagahiro, Yukio, Shimizu, Keiko, Umegae, Nobuyuki, Hayase, Nobumasa, Shiono, Hiroshi, Kobayashi, Shotai

“…Peroxynitrite can nitrate tyrosine residues of proteins. We examined nitrotyrosine‐containing proteins in cerebrospinal fluid of 66 patients with neurogenic…”
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Enhanced discrimination of single nucleotide polymorphisms using 3′ nucleotide differences in ligase detection reaction probes by Asari, Masaru, Omura, Tomohiro, Maseda, Chikatoshi, Shiono, Hiroshi, Tasaki, Yoshikazu, Matsubara, Kazuo, Shimizu, Keiko

“…The ligase detection reaction (LDR) is a highly specific genotyping method for single nucleotide variations. Although LDR typically discriminates single…”
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Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents by Matsubara, Kazuo, Asari, Masaru, Suno, Manabu, Awaya, Toshio, Sugawara, Mitsuru, Omura, Tomohiro, Yamamoto, Joe, Maseda, Chikatoshi, Tasaki, Yoshikazu, Shiono, Hiroshi, Shimizu, Keiko

“…Abstract When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can…”
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Brain stem hemorrhage due to cerebral amyloid angiopathy: The autopsy of a patient with Alzheimer’s disease at a young age by Ohtani, Seiji, Shimizu, Keiko, Asari, Masaru, Maseda, Chikatoshi, Oka, Kumiko, Yamada, Hiromi, Hoshina, Chisato, Doi, Hiroki, Yajima, Daisuke, Shiono, Hiroshi, Ogawa, Katsuhiro

“…Abstract We report findings from an autopsy of a male in his 40s who died of a brain stem hemorrhage associated with cerebral amyloid angiopathy (CAA), senile…”
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Utility of haplogroup determination for forensic mtDNA analysis in the Japanese population by Asari, Masaru, Umetsu, Kazuo, Adachi, Noboru, Azumi, Jun-ichi, Shimizu, Keiko, Shiono, Hiroshi

“…Abstract Sequence analysis of the hypervariable regions (HVRs) of mitochondrial DNA (mtDNA) are routinely performed in forensic casework, however, there are…”
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Systematic classification of alleles of the glycophorin A (MN blood group) gene by Mizukami, Hajime, Akane, Atsushi, Nakayashiki, Nori, Aoki, Yasuhiro, Shiono, Hiroshi

“…Ten alleles (five M and five N alleles) of the MN blood group system with normal antigenicity were found by sequencing the glycophorin A (GPA) gene. This study…”
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