Search Results - "Hirose, Tetsuro"

Paraspeckle formation during the biogenesis of long non-coding RNAs by Naganuma, Takao, Hirose, Tetsuro

“…Paraspeckles are unique subnuclear structures that are built around a specific long non-coding RNA (lncRNA), NEAT1, which is comprised of two isoforms (NEAT1_1…”
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Control of condensates dictates nucleolar architecture by Yamazaki, Tomohiro, Hirose, Tetsuro

“…Long noncoding RNA directs biophysical properties of phase-separated nucleoli Intracellular organelles that lack a membrane boundary are often formed through…”
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Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function by Chujo, Takeshi, Hirose, Tetsuro

“…Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis,…”
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Molecular anatomy of the architectural NEAT1 noncoding RNA: The domains, interactors, and biogenesis pathway required to build phase‐separated nuclear paraspeckles by Hirose, Tetsuro, Yamazaki, Tomohiro, Nakagawa, Shinichi

“…Long noncoding RNAs (lncRNAs) are extremely diverse and have various significant physiological functions. lncRNAs generally associate with specific sets of…”
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Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu by Nakagawa, Shinichi, Yamazaki, Tomohiro, Hirose, Tetsuro

“…Paraspeckles are nuclear bodies built on an architectural long noncoding RNA, NEAT1, and a series of studies have revealed their molecular components, fine…”
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Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs by Chujo, Takeshi, Yamazaki, Tomohiro, Kawaguchi, Tetsuya, Kurosaka, Satoshi, Takumi, Toru, Nakagawa, Shinichi, Hirose, Tetsuro

“…NEAT1_2 long noncoding RNA (lncRNA) is the molecular scaffold of paraspeckle nuclear bodies. Here, we report an improved RNA extraction method: extensive…”
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Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model by Shibata, Tomonori, Nagano, Konami, Ueyama, Morio, Ninomiya, Kensuke, Hirose, Tetsuro, Nagai, Yoshitaka, Ishikawa, Kinya, Kawai, Gota, Nakatani, Kazuhiko

“…Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine…”
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Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization by West, Jason A, Mito, Mari, Kurosaka, Satoshi, Takumi, Toru, Tanegashima, Chiharu, Chujo, Takeshi, Yanaka, Kaori, Kingston, Robert E, Hirose, Tetsuro, Bond, Charles, Fox, Archa, Nakagawa, Shinichi

“…Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a variety of physiological processes including cancer progression and…”
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Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles by Naganuma, Takao, Nakagawa, Shinichi, Tanigawa, Akie, Sasaki, Yasnory F, Goshima, Naoki, Hirose, Tetsuro

“…Paraspeckles are unique subnuclear structures built around a specific long noncoding RNA, NEAT1, which is comprised of two isoforms produced by alternative…”
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Architectural RNAs for Membraneless Nuclear Body Formation by Yamazaki, Tomohiro, Nakagawa, Shinichi, Hirose, Tetsuro

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Phase separation driven by production of architectural RNA transcripts by Yamamoto, Tetsuya, Yamazaki, Tomohiro, Hirose, Tetsuro

“…We here use an extension of the Flory-Huggins theory to predict that phase separation is driven by the production of architectural RNA (arcRNA) at a DNA locus…”
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ArcRNAs and the formation of nuclear bodies by Nakagawa, Shinichi, Yamazaki, Tomohiro, Mannen, Taro, Hirose, Tetsuro

“…Long noncoding RNAs (lncRNAs) have long been collectively and passively defined as transcripts that do not encode proteins. However, extensive functional…”
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SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns by Fukumura, Kazuhiro, Yoshimoto, Rei, Sperotto, Luca, Kang, Hyun-Seo, Hirose, Tetsuro, Inoue, Kunio, Sattler, Michael, Mayeda, Akila

“…Human pre-mRNA introns vary in size from under fifty to over a million nucleotides. We searched for essential factors involved in the splicing of human short…”
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The long noncoding RNA Neat1 is required for mammary gland development and lactation by Standaert, Laura, Adriaens, Carmen, Radaelli, Enrico, Van Keymeulen, Alexandra, Blanpain, Cedric, Hirose, Tetsuro, Nakagawa, Shinichi, Marine, Jean-Christophe

“…The lncRNA Neat1 is an essential architectural component of paraspeckle nuclear bodies. Although cell-based studies identified Neat1-paraspeckles as key…”
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The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice by Nakagawa, Shinichi, Shimada, Masayuki, Yanaka, Kaori, Mito, Mari, Arai, Takashi, Takahashi, Eiki, Fujita, Youko, Fujimori, Toshihiko, Standaert, Laura, Marine, Jean-Christophe, Hirose, Tetsuro

“…Neat1 is a non-protein-coding RNA that serves as an architectural component of the nuclear bodies known as paraspeckles. Although cell-based studies indicate…”
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NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies by Hirose, Tetsuro, Virnicchi, Giorgio, Tanigawa, Akie, Naganuma, Takao, Li, Ruohan, Kimura, Hiroshi, Yokoi, Takahide, Nakagawa, Shinichi, Bénard, Marianne, Fox, Archa H, Pierron, Gérard

“…Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that…”
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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies by Kawaguchi, Tetsuya, Tanigawa, Akie, Naganuma, Takao, Ohkawa, Yasuyuki, Souquere, Sylvie, Pierron, Gerard, Hirose, Tetsuro

“…Significance The postgenomic era has seen the identification of numerous long noncoding RNA (lncRNAs) in mammalian cells; however, their biological functions…”
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The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL by Mannen, Taro, Yamashita, Seisuke, Tomita, Kozo, Goshima, Naoki, Hirose, Tetsuro

“…The mammalian cell nucleus contains membraneless suborganelles referred to as nuclear bodies (NBs). Some NBs are formed with an architectural RNA (arcRNA) as…”
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MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles by Sasaki, Yasnory T.F, Ideue, Takashi, Sano, Miho, Mituyama, Toutai, Hirose, Tetsuro

“…Recent transcriptome analyses have shown that thousands of noncoding RNAs (ncRNAs) are transcribed from mammalian genomes. Although the number of functionally…”
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Neat1 is a p53-inducible lincRNA essential for transformation suppression by Mello, Stephano S, Sinow, Carolyn, Raj, Nitin, Mazur, Pawel K, Bieging-Rolett, Kathryn, Broz, Daniela Kenzelmann, Imam, Jamie F Conklin, Vogel, Hannes, Wood, Laura D, Sage, Julien, Hirose, Tetsuro, Nakagawa, Shinichi, Rinn, John, Attardi, Laura D

“…The gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces…”
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