Search Results - "Hirono, Iwao"

Edible Plants Containing Naturally Occurring Carcinogens in Japan by Hirono, Iwao

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Demonstration of ras and p53 Gene Mutations in Carcinomas in the Forestomach and Intestine and Soft Tissue Sarcomas Induced by N‐Methyl‐N‐nitrosourea in the Rat by Matsumoto, Kazuyuki, Iwase, Teruhiko, Hirono, Iwao, Nishida, Yoshihisa, Iwahori, Yoshio, Hori, Takaaki, Asamoto, Makoto, Takasuka, Nobuo, Kim, Dae Joong, Ushijima, Toshikazu, Nagao, Minako, Tsuda, Hiroyuki

“…The presence of ras family and p53 gene mutations in rat forestomach, intestine and liver tumors and soft tissue sarcomas induced by Nmethyl‐N‐nitrosourea…”
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Histogenetic stereological reconstruction of rat basophilic, clear, and oncocytic neoplastic renal cell lesions using carbonic anhydrase type II-PAS double-stained sections by Tsuda, H, Iwase, T, Matsumoto, K, Ito, M, Hirono, I, Nishida, Y, Takasuka, N, Iwahori, Y, Ota, T, Kim, D J, Kadenbach, B

“…The histogenesis of 3 types of rat renal cell tumors (basophilic cell, clear cell, and oncocytic) was stereologically analyzed, with particular attention paid…”
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Decreased Levels of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐DNA Adducts in Rats Treated with β‐Carotene, α‐Tocopherol and Freeze‐dried Aloe by Uehara, Nobuaki, Iwahori, Yoshio, Asamoto, Makoto, Baba‐Toriyama, Hiroyasu, Iigo, Masaaki, Ochiai, Masako, Nagao, Minako, Nakayama, Masafumi, Degawa, Masakuni, Matsumoto, Kazuyuki, Hirono, Iwao, Beppu, Hidehiko, Fujita, Keisuke, Tsuda, Hiroyuki

“…To assess mechanisms of chemoprevention of hepatocarcinogenesis by trans‐β‐carotene (β‐C), DL‐α‐tocopherol (α‐T), and freeze‐dried whole leaves of Kidachi aloe…”
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Retinal degeneration induced by N-methyl-N-nitrosourea and detection of 7-methyldeoxyguanosine in the rat retina by Ogino, H, Ito, M, Matsumoto, K, Yagyu, S, Tsuda, H, Hirono, I, Wild, C P, Montesano, R

“…Retinal degeneration induced by a single parenteral dose (40 mg) of N-methyl-N-nitrosourea (MNU) was studied in rats and rabbits. Sequential observations…”
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Induction of colorectal tumors in rats by sulfated polysaccharides by Ishioka, T, Kuwabara, N, Oohashi, Y, Wakabayashi, K

“…Some sulfated polysaccharides, such as d-CGN, APS, and DSS, have carcinogenicity to the rat colorectum. These materials first induced colitis, secondly…”
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Carcinogenicity examination of quercetin and rutin in ACI rats by Hirono, I, Ueno, I, Hosaka, S, Takanashi, H, Matsushima, T, Sugimura, T, Natori, S

“…Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days,…”
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Genotoxic activity in vivo of the naturally occurring glucoside, cycasin, in the Drosophila wing spot test by Kawai, Kazuaki, Furukawa, Hideyuki, Hirono, Iwao

“…Cycasin, methylazoxymethanol-β-glucoside, is a naturally occurring carcinogenic compound. The genotoxicity of cycasin was assayed in the Drosophila wing spot…”
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Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan by Hosaka, S, Matsushima, T, Hirono, I, Sugimura, T

“…The carcinogenic activity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan, was studied in inbred strain ACI rats…”
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Genotoxicity of a Variety of Hydrazine Derivatives in the Hepatocyte Primary Culture/DNA Repair Test Using Rat and Mouse Hepatocytes by Mori, Hideki, Sugie, Shigeyuki, Yoshime, Naoki, Iwata, Hitoshi, Nishikawa, Akiyoshi, Matsukubo, Kogen, Shimizu, Hidesuke, Hirono, Iwao

“…The genotoxicity of a variety of hydrazine derivatives was examined in the DNA‐repair test on rat or mouse hepatocytes. Out of 32 hydrazine derivatives, 6…”
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Separation of carcinogenic fraction of bracken fern by Hirono, I, Yamada, K, Niwa, H, Shizuri, Y, Ojika, M, Hosaka, S, Yamaji, T, Wakamatsu, K, Kigoshi, H, Niiyama, K

“…Isolation of the carcinogen in the boiling water extract of bracken fern was conducted by following the active principle with a carcinogenicity bioassay…”
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COMPARISON OF THE EFFECTS OF BILOBOL AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON SKIN, AND TEST OF TUMOR PROMOTING POTENTIAL OF BILOBOL IN CD-1 MICE by MATSUMOTO, Kazuyuki, FUJIMOTO, Masao, ITO, Kazuo, TANAKA, Hitoshi, HIRONO, Iwao

“…Bilobol, isolated from ginkgo fruit pulp, has been noted to be a strong skin irritant like 12-o-tetradecanoylphorbol-13-acetate (TPA), a tumor-promoter in the…”
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A Comparative Study of the Mode of Action of X-Rays and Alkylating Agents by HIRONO, IWAO

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Carcinogenicity of dextran sulfate sodium in relation to its molecular weight by Hirono, I, Kuhara, K, Yamaji, T, Hosaka, S, Golberg, L

“…The carcinogenicity of dextran and 3 kinds of dextran sulfate sodium with different molecular weights and almost the same sulfur content were compared in ACI…”
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Chemopreventive Effects of β‐Carotene, α‐Tocopherol and Five Naturally Occurring Antioxidants on Initiation of Hepatocarcinogenesis by 2‐Amino‐3‐methylimidazo[4,5‐f] qumoline in the Rat by Tsuda, Hiroyuki, Uehara, Nobuaki, Iwahori, Yoshio, Asamoto, Makoto, Ligo, Masaaki, Nagao, Minako, Matsumoto, Kazuyuki, Ito, Mitsuya, Hirono, Iwao

“…Inhibitory effects of naturally occurring antioxidants on the initiation stage of hepatocarcinogenesis were studied. Group 1 rats were given a diet containing…”
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Induction of colorectal squamous cell carcinomas in rats by dextran sulfate sodium by Hirono, I, Kuhara, K, Yamaji, T, Hosaka, S, Golberg, L

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INFLUENCE OF PTAQUILOSIDE ON THE DEVELOPMENT OF NEWBORN MICE by FUJIMOTO, Masao, OGINO, Hiroshi, HIRONO, Iwao

“…We attempted to induce neurological disorders in mice by a single administration of various doses of ptaquiloside (PT) within 24 h after birth. Animals which…”
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Effect of degraded carrageenan on the intestine in germfree rats by Hirono, I, Sumi, Y, Kuhara, K, Miyakawa, M

“…The role of intestinal bacterial flora in display of the effect of degraded carrageenan was investigated by feeding 9 germfree and 12 conventional female…”
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K‐ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction by Matsubara, Toshiki, Sakurai, Yoichi, Sasayama, Yoshinori, Hori, Haruna, Ochiai, Masahiro, Funabiki, Takahiko, Matsumoto, Kazuyuki, Hirono, Iwao

“…BACKGROUND Pancreaticobiliary maljunction (PBM), an anomalous union of the pancreatic duct with the common bile duct, has frequently been shown to be…”
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Carcinogenicity examination of inflorescence of Zingiber mioga Roscoe by Hirono, I, Mori, H, Kato, K, Hosaka, S, Aiso, S

“…The carcinogenicity of mioga was examined in ACI and Fischer 344 rats. In Experiment I, a test group of ACI rats received diet containing mioga for 365 days,…”
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