Search Results - "Hironaka, Kohei"

Severe Aneurysmal Subarachnoid Hemorrhage after Warning Headache during Pregnancy: A Case Report by Hironaka, Kohei, Suzuki, Masanori, Tateyama, Kojiro, Ozeki, Tomohiro, Adachi, Koji, Morita, Akio

“…Background: Aneurysmal subarachnoid hemorrhage is a rare but important cause of maternal death during pregnancy. Case Description: A 34-year-old primigravida…”
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Liposomal diclofenac eye drop formulations targeting the retina: Formulation stability improvement using surface modification of liposomes by Fujisawa, Takuya, Miyai, Hiroko, Hironaka, Kohei, Tsukamoto, Toshimasa, Tahara, Kohei, Tozuka, Yuichi, Ito, Masaki, Takeuchi, Hirofumi

“…The modifying liposome surface with polyvinyl alcohol or its derivative prevented the liposome aggregation and/or fusion during remote loading process, leading…”
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Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector by Hironaka, Kohei, Yamazaki, Yoshiyuki, Hirai, Yukihiko, Yamamoto, Motoko, Miyake, Noriko, Miyake, Koichi, Okada, Takashi, Morita, Akio, Shimada, Takashi

“…Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency in human arylsulfatase A (hASA). We recently reported that…”
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Outcome and Refractory Factor of Intensive Treatment for Geriatric Traumatic Brain Injury: Analysis of 1165 Cases Registered in the Japan Neurotrauma Data Bank by Yokobori, Shoji, Yamaguchi, Masahiro, Igarashi, Yutaka, Hironaka, Kohei, Onda, Hidetaka, Kuwamoto, Kentaro, Araki, Takashi, Fuse, Akira, Yokota, Hiroyuki

“…Objective With the increase in the aged population, geriatric traumatic brain injury (gTBI) is also rapidly increasing in Japan. There is thus a need to review…”
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Simple Solution for Preventing Cerebrospinal Fluid Loss and Brain Shift During Multitrack Deep Brain Stimulation Surgery in the Semisupine Position: Polyethylene Glycol Hydrogel Dural Sealant Capping: Rapid Communication by TAKUMI, Ichiro, MISHINA, Masahiro, HIRONAKA, Kohei, OYAMA, Kenichi, YAMADA, Akira, ADACHI, Koji, HAMAMOTO, Makoto, KITAMURA, Shin, YOSHIDA, Daizo, TERAMOTO, Akira

“…This study evaluated preliminary findings on the efficacy of polyethylene glycol (PEG) hydrogel dural sealant capping for the prevention of cerebrospinal fluid…”
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Fluorescence Investigation of the Retinal Delivery of Hydrophilic Compounds via Liposomal Eyedrops by Hironaka, Kohei, Fujisawa, Takuya, Sasaki, Hitoshi, Tozuka, Yuichi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki, Takeuchi, Hirofumi

“…We examined the feasibility of using submicron-sized liposomes (ssLips) for retinal delivery of hydrophilic compounds, which would also have a wide range of…”
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Simple Solution for Preventing Cerebrospinal Fluid Loss and Brain Shift During Multitrack Deep Brain Stimulation Surgery in the Semisupine Position: Polyethylene Glycol Hydrogel Dural Sealant Capping by Takumi, Ichiro, Mishina, Masahiro, Hironaka, Kohei, Oyama, Kenichi, Yamada, Akira, Adachi, Koji, Hamamoto, Makoto, Kitamura, Shin, Yoshida, Daizo, Teramoto, Akira

“…This study evaluated preliminary findings on the efficacy of polyethylene glycol (PEG) hydrogel dural sealant capping for the prevention of cerebrospinal fluid…”
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IMPROVEMENT OF THE RETINAL DELIVERY OF EYEDROP CONTAINING LIPOSOMES BY CHITOSAN MODIFICATION by Hironaka, Kohei, Nakanishi, Tomohiro, Fujisawa, Takuya, Sasaki, Hitoshi, Tahara, Kohei, Tozuka, Yuichi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki, Takeuchi, Hirofumi

“…Intravitreal injection is well-known commonly used way to deliver drug to the retina whereas repeated injections involve potential risks of complications. We…”
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Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye by Hironaka, Kohei, Inokuchi, Yuta, Tozuka, Yuichi, Shimazawa, Masamitsu, Hara, Hideaki, Takeuchi, Hirofumi

“…The purpose of this study was to evaluate the potential of submicron-sized liposomes (ssLips) as a novel system for delivering ocular drugs to the eye's…”
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Retinal drug delivery using eyedrop preparations of poly-l-lysine-modified liposomes by Sasaki, Hitoshi, Karasawa, Keiichi, Hironaka, Kohei, Tahara, Kohei, Tozuka, Yuichi, Takeuchi, Hirofumi

“…The poly-l-lysine (PLL) as a liposomal surface modifier enhances the efficiency of submicron-sized liposomal retina delivery by eye drop. The purpose of this…”
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Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord by Hironaka, Kohei, Tateyama, Kojiro, Tsukiyama, Atsushi, Adachi, Koji, Morita, Akio

“…Hydrocephalus secondary to spinal cord tumors is rare. We present a 39-year-old male with gradual-onset headache whose initial diagnosis was cerebral aneurysm…”
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Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice by Shimazaki, Hiroki, Hironaka, Kohei, Fujisawa, Takuya, Tsuruma, Kazuhiro, Tozuka, Yuichi, Shimazawa, Masamitsu, Takeuchi, Hirofumi, Hara, Hideaki

“…To investigate the pharmacologic effects of eyedrops containing liposomes loaded with edaravone (3-methyl-1-phenyl-2-pyrazolin-5-1) against light-induced…”
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Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration by Inokuchi, Yuta, Hironaka, Kohei, Fujisawa, Takuya, Tozuka, Yuichi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Takeuchi, Hirofumi, Hara, Hideaki

“…To elucidate the effect of physicochemical properties of nanocarrier systems on drug delivery efficiency to the retina by eyedrop administration in mice,…”
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Outcomes in Elderly Japanese Patients Treated for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Nationwide Study by Hironaka, Kohei, Aso, Shotaro, Suzuki, Masanori, Matano, Fumihiro, Matsui, Hiroki, Fushimi, Kiyohide, Yasunaga, Hideo, Morita, Akio

“…Objective: Japan has the largest elderly population in the world. As data on the clinical outcomes in elderly patients with aneurysmal subarachnoid hemorrhage…”
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Cerebral Aneurysm Associated with an Arachnoid Cyst: 3 Case Reports and a Systematic Review of the Literature by Igarashi, Yutaka, Murai, Yasuo, Yamada, Osamu, Shirokane, Kazutaka, Hironaka, Kohei, Sato, Shun, Sugiyama, Makoto, Tachizawa, Takayuki, Morita, Akio

“…Arachnoid cysts and intracranial aneurysms are not rare, but it is unusual for an aneurysm to be associated with an arachnoid cyst. The objective of this study…”
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Preparation of bromfenac-loaded liposomes modified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile by Tsukamoto, Toshimasa, Hironaka, Kohei, Fujisawa, Takuya, Yamaguchi, Daiki, Tahara, Kohei, Tozuka, Yuichi, Takeuchi, Hirofumi

“…The purpose of this study was to design a submicron-sized liposomal non-steroidal anti-inflammatory drug (NSAID) preparation that targets the retina via…”
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Development and In Vitro Characterization of Liposomes Coated with Thiolated Poly(Acrylic Acid) for Oral Drug Delivery by Werle, Martin, Hironaka, Kohei, Takeuchi, Hirofumi, Hoyer, Herbert

“…Mucoadhesive drug delivery systems offer promising opportunities for oral drug delivery. The aim of this study was to investigate the feasibility of preparing…”
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Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage by Hironaka, Kohei, Inokuchi, Yuta, Fujisawa, Takuya, Shimazaki, Hiroki, Akane, Mai, Tozuka, Yuichi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki, Takeuchi, Hirofumi

“…Edaravone-loaded liposomes significantly reduced N-methyl- d-aspartate(NMDA)-induced retinal damage compared with free edaravone after intravitreal injection…”
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Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage: New Facets of Nanopharmaceutics by HIRONAKA, Kohei, INOKUCHI, Yuta, FUJISAWA, Takuya, SHIMAZAKI, Hiroki, AKANE, Mai, TOZUKA, Yuichi, TSURUMA, Kazuhiro, SHIMAZAWA, Masamitsu, HARA, Hideaki, TAKEUCHI, Hirofumi

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Synthesis and Characterization of LnF(HF)(BF4)2 (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, and Dy), and Crystal Structures of LnF(HF)(BF4)2 (Ln = Pr, Nd) and La(BF4)3 by Mazej, Zoran, Goreshnik, Evgeny, Hironaka, Kohei, Katayama, Yasushi, Hagiwara, Rika

“…Rare earth trifluorides (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, and Dy) react with boron trifluoride in anhydrous hydrogen fluoride (aHF) at room temperature…”
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