Search Results - "Hiromatsu, Kenji"

Bortezomib Eliminates Persistent Chlamydia trachomatis Infection through Rapid and Specific Host Cell Apoptosis by Itoh, Ryota, Kurihara, Yusuke, Yoshimura, Michinobu, Hiromatsu, Kenji

“…Chlamydia trachomatis, a parasitic intracellular bacterium, is a major human pathogen that causes millions of trachoma, sexually transmitted infections, and…”
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Loss of ATP2A2 Allows Herpes Simplex Virus 1 Infection of a Human Epidermis Model by Disrupting Innate Immunity and Barrier Function by Sato, Emi, Hiromatsu, Kenji, Murata, Kunihiko, Imafuku, Shinichi

“…Destruction of epidermal barrier function associated with atopic dermatitis or Darier’s disease often causes severe secondary skin infections. Patients with…”
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The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines by Yoshimura, Michinobu, Sakamoto, Atsuhiko, Ozuru, Ryo, Kurihara, Yusuke, Itoh, Ryota, Ishii, Kazunari, Shimizu, Akinori, Chou, Bin, Nabeshima, Shigeki, Hiromatsu, Kenji

“…It is crucial to analyze the consequences of repeated messenger RNA (mRNA)-based COVID-19 vaccinations on SARS-CoV-2 spike receptor binding domain…”
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Anti-chlamydial activities of cell-permeable hydrophobic dipeptide-containing derivatives by Itoh, Ryota, Soejima, Toshinori, Hiromatsu, Kenji

“…The obligate intracellular bacteria chlamydia is major human pathogen that causes millions of trachoma, sexually transmitted infections and pneumonia…”
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Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid-Binding Protein 4-Dependent White Adipose Tissue Pathology by Kurihara, Yusuke, Walenna, Nirwana Fitriani, Ishii, Kazunari, Soejima, Toshinori, Chou, Bin, Yoshimura, Michinobu, Ozuru, Ryo, Shimizu, Akinori, Itoh, Ryota, Furuhashi, Masato, Hotamisligil, Gökhan S, Hiromatsu, Kenji

“…Fatty acid-binding protein 4 (FABP4) is a critical immune-metabolic modulator, mainly expressed in adipocytes and macrophages, secreted from adipocytes in…”
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Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis by Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro, Nishi, Tatsuro, Nishi, Ryushiro, Tanaka, Takayuki, Tsunoda, Toshiyuki, Imai, Kazuaki, Tanaka, Hiroaki, Hotta, Osamu, Tanaka, Ayaki, Hiromatsu, Kenji, Shirasawa, Senji, Nakagawa, Takashi, Yamano, Takafumi

“…The epipharynx, located behind the nasal cavity, is responsible for upper respiratory tract immunity; however, it is also the site of frequent acute and…”
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Epipharyngeal Abrasive Therapy Down-regulates the Expression of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2 by Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro, Tsunoda, Toshiyuki, Ohno, Jun, Yoshimura, Michinobu, Hiromatsu, Kenji, Yamano, Takafumi

“…The epipharynx, with its high expression of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) entry factors angiotensin-converting enzyme 2 (ACE2)…”
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Ephedrae Herba and Cinnamomi Cortex interactions with G glycoprotein inhibit respiratory syncytial virus infectivity by Fujikane, Aya, Sakamoto, Atsuhiko, Fujikane, Ryosuke, Nishi, Akinori, Ishino, Yoshizumi, Hiromatsu, Kenji, Nabeshima, Shigeki

“…Although respiratory syncytial virus (RSV) is a major cause of respiratory tract infection in children, no effective therapies are available. Recently, RSV G,…”
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Antiviral effect of alkaloids-free Ephedra Herb extract on respiratory syncytial virus infection by Fujikane, Aya, Fujikane, Ryosuke, Hyuga, Sumiko, Sechi, Yusuke, Hiyoshi, Tetsuya, Sakamoto, Atsuhiko, Nishi, Akinori, Odaguchi, Hiroshi, Hiromatsu, Kenji, Goda, Yukihiro, Ishino, Yoshizumi, Nabeshima, Shigeki

“…Respiratory syncytial virus (RSV) is a major cause of respiratory tract infection in children. Despite decades of efforts, no effective therapies are…”
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Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy by Yamashita, Kanefumi, Sasaki, Takamitsu, Itoh, Ryota, Kato, Daisuke, Hatano, Naoya, Soejima, Toshinori, Ishii, Kazunari, Takenawa, Tadaomi, Hiromatsu, Kenji, Yamashita, Yuichi

“…Background Pancreatic fistula after pancreatoduodenectomy (PD) is associated with high mortality and morbidity. Trypsinogen activation and bacteria, although…”
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Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry by NISHI, KENSUKE, YOSHIMOTO, SHOHEI, NISHI, SOICHIRO, NISHI, TATSURO, NISHI, RYUSHIRO, TSUNODA, TOSHIYUKI, MORITA, HIROMITSU, TANAKA, HIROAKI, HOTTA, OSAMU, YASUMASU, SUSUMU, HIROMATSU, KENJI, SHIRASAWA, SENJI, NAKAGAWA, TAKASHI, YAMANO, TAKAFUMI

“…BACKGROUND/AIMInfluenza A virus (IAV) infection causes an inflammatory response to the respiratory mucosa. The viral glycoprotein hemagglutinin (HA) binds to…”
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Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment by Imai, Kazuaki, Yamano, Takafumi, Nishi, Soichiro, Nishi, Ryushiro, Nishi, Tatsuro, Tanaka, Hiroaki, Tsunoda, Toshiyuki, Yoshimoto, Shohei, Tanaka, Ayaki, Hiromatsu, Kenji, Shirasawa, Senji, Nakagawa, Takashi, Nishi, Kensuke

“…COVID-19 often causes sequelae after initial recovery, referred to collectively as long COVID. Long COVID is considered to be caused by the persistence of…”
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Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan by Sakamoto, Atsuhiko, Yoshimura, Michinobu, Itoh, Ryota, Ozuru, Ryo, Ishii, Kazunari, Sechi, Yusuke, Nabeshima, Shigeki, Hiromatsu, Kenji

“…Analysis of longitudinal dynamics of humoral immune responses to the BNT162b2 COVID-19 vaccine might provide useful information to predict the effectiveness of…”
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Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus by Hiromatsu, Kenji, Ishii, Kazunari, Itoh, Ryota, Yamauchi, Kei, Ajisaka, Kazuhiko, Nabeshima, Shigeki, Masui, Shinta, Soejima, Toshinori

“…We previously reported in randomized controlled trials that maoto, a traditional herbal medicine, showed clinical and virological efficacy for seasonal…”
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Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells by Sato, Emi, Imafuku, Shinichi, Ishii, Kazunari, Itoh, Ryota, Chou, Bin, Soejima, Toshinori, Nakayama, Juichiro, Hiromatsu, Kenji

“…Abstract Background 1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3) up-regulates the production of human cathelicidin antimicrobial peptide (CAMP) from…”
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Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 by Yoshimura, Michinobu, Sakamoto, Atsuhiko, Ozuru, Ryo, Kurihara, Yusuke, Itoh, Ryota, Ishii, Kazunari, Shimizu, Akinori, Chou, Bin, Sechi, Yusuke, Fujikane, Aya, Nabeshima, Shigeki, Hiromatsu, Kenji

“…This study aims to examine whether the parenterally administered mRNA-based COVID-19 vaccines can induce sufficient mucosal-type IgA responses to prevent…”
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A Microbial Glycolipid Functions as a New Class of Target Antigen for Delayed-type Hypersensitivity by Komori, Takaya, Nakamura, Takashi, Matsunaga, Isamu, Morita, Daisuke, Hattori, Yuki, Kuwata, Hirotaka, Fujiwara, Nagatoshi, Hiromatsu, Kenji, Harashima, Hideyoshi, Sugita, Masahiko

“…Delayed-type hypersensitivity (DTH) is marked by high levels of protein antigen-specific T cell responses in sensitized individuals. Recent evidence has…”
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Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs by Hattori, Yuki, Matsunaga, Isamu, Komori, Takaya, Urakawa, Tetsuo, Nakamura, Takashi, Fujiwara, Nagatoshi, Hiromatsu, Kenji, Harashima, Hideyoshi, Sugita, Masahiko

“…► The biosynthesis of glycerol monomycolate is associated with latent tuberculosis. ► The expression of glycerol monomycolate in BCG is inducible. ► Immunized…”
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Antiangiogenic tumor therapy by DNA vaccine inducing aquaporin-1-specific CTL based on ubiquitin-proteasome system in mice by Chou, Bin, Hiromatsu, Kenji, Okano, Shinji, Ishii, Kazunari, Duan, Xuefeng, Sakai, Tohru, Murata, Shigeo, Tanaka, Keiji, Himeno, Kunisuke

“…Aquaporin-1 (AQP-1) is a water channel protein highly expressed in the vascular endothelial cells of proliferating tissues including malignant cancers. Given…”
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MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis by Kiyoshima, Chihiro, Shirasu, Naoto, Urushiyama, Daichi, Fukagawa, Satoshi, Hirakawa, Toyofumi, Yoshikawa, Kenichi, Izuchi, Daisuke, Miyata, Kohei, Kurakazu, Masamitsu, Yotsumoto, Fusanori, Hiromatsu, Kenji, Nomiyama, Makoto, Eiji, Ohta, Hirose, Shinichi, Ogura, Yoshitoshi, Hayashi, Tetsuya, Hata, Kenichiro, Nabeshima, Kazuki, Yasunaga, Shin'ichiro, Miyamoto, Shingo

“…This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. Amniotic fluid samples from 37…”
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