Search Results - "Hiroko Segawa"

Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia by Sasaki, Sumire, Shiozaki, Yuji, Hanazaki, Ai, Koike, Megumi, Tanifuji, Kazuya, Uga, Minori, Kawahara, Kota, Kaneko, Ichiro, Kawamoto, Yasuharu, Wiriyasermkul, Pattama, Hasegawa, Tomoka, Amizuka, Norio, Miyamoto, Ken-ichi, Nagamori, Shushi, Kanai, Yoshikatsu, Segawa, Hiroko

“…Renal type II sodium-dependent inorganic phosphate (Pi) transporters NaPi2a and NaPi2c cooperate with other organs to strictly regulate the plasma Pi…”
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The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration by Miyagawa, Atsumi, Tatsumi, Sawako, Takahama, Wako, Fujii, Osamu, Nagamoto, Kenta, Kinoshita, Emi, Nomura, Kengo, Ikuta, Kayo, Fujii, Toru, Hanazaki, Ai, Kaneko, Ichiro, Segawa, Hiroko, Miyamoto, Ken-Ichi

“…Circulating inorganic phosphate exhibits a remarkable daily oscillation based on food intake. In humans and rodents, the daily oscillation in response to food…”
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NAD metabolism and the SLC34 family: evidence for a liver-kidney axis regulating inorganic phosphate by Tatsumi, Sawako, Katai, Kanako, Kaneko, Ichiro, Segawa, Hiroko, Miyamoto, Ken-ichi

“…The solute carrier 34 (SLC34) family of membrane transporters is a major contributor to Pi homeostasis. Many factors are involved in regulating the SLC34…”
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Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder by Tanifuji, Kazuya, Shiozaki, Yuji, Koike, Megumi, Uga, Minori, Komiya, Aoi, Miura, Mizuki, Higashi, Ayami, Shimohata, Takaaki, Takahashi, Akira, Ishizuka, Noriko, Hayashi, Hisayoshi, Ichida, Yasuhiro, Ohtomo, Shuichi, Horiba, Naoshi, Miyamoto, Ken-ichi, Segawa, Hiroko

“…Background : Inorganic phosphate (Pi) binders are the only pharmacologic treatment approved for hyperphosphatemia. However, Pi binders induce the expression of…”
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The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism by Uga, Minori, Kaneko, Ichiro, Shiozaki, Yuji, Koike, Megumi, Tsugawa, Naoko, Jurutka, Peter W, Miyamoto, Ken-Ichi, Segawa, Hiroko

“…Vitamin D hydroxylation in the liver/kidney results in conversion to its physiologically active form of 1,25-dihydroxyvitamin D [1,25(OH) D ]. 1,25(OH) D…”
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Systemic network for dietary inorganic phosphate adaptation among three organs by Ikuta, Kayo, Segawa, Hiroko, Hanazaki, Ai, Fujii, Toru, Kaneko, Ichiro, Shiozaki, Yuji, Tatsumi, Sawako, Ishikawa, Yasuko, Miyamoto, Ken-ichi

“…Inorganic phosphate (Pi) secretion from the salivary glands and dietary Pi are key Pi sources. The regulatory mechanisms of Pi homeostasis in the salivary…”
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Involvement of α-klotho in growth hormone (GH) signaling by Koike, Megumi, Sato, Tetsuhiko, Shiozaki, Yuji, Komiya, Aoi, Miura, Mizuki, Higashi, Ayami, Ishikawa, Akane, Takayanagi, Kaori, Uga, Minori, Miyamoto, Ken-ichi, Segawa, Hiroko

“…Growth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we…”
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Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development by Segawa, Hiroko, Onitsuka, Akemi, Furutani, Junya, Kaneko, Ichiro, Aranami, Fumito, Matsumoto, Natsuki, Tomoe, Yuka, Kuwahata, Masashi, Ito, Mikiko, Matsumoto, Mitsuru, Li, Minqi, Amizuka, Norio, Miyamoto, Ken-ichi

“…Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare autosomal recessively inherited disorder, characterized by hypophosphatemia, short…”
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Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling by Ikuta, Kayo, Segawa, Hiroko, Sasaki, Shohei, Hanazaki, Ai, Fujii, Toru, Kushi, Aoi, Kawabata, Yuka, Kirino, Ruri, Sasaki, Sumire, Noguchi, Miwa, Kaneko, Ichiro, Tatsumi, Sawako, Ueda, Otoya, Wada, Naoko A., Tateishi, Hiromi, Kakefuda, Mami, Kawase, Yosuke, Ohtomo, Shuichi, Ichida, Yasuhiro, Maeda, Akira, Jishage, Kou-ichi, Horiba, Naoshi, Miyamoto, Ken-ichi

“…Background Hyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na + -dependent phosphate…”
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The Role of Sodium-Dependent Phosphate Transporter in Phosphate Homeostasis by SEGAWA, Hiroko, SHIOZAKI, Yuji, KANEKO, Ichiro, MIYAMOTO, Ken-ichi

“…Inorganic phosphate (Pi) is an essential compound for several biologic functions. Pi levels outside the normal range, however, contribute to several…”
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Dietary polyphosphate has a greater effect on renal damage and FGF23 secretion than dietary monophosphate by Sasaki, Sumire, Koike, Megumi, Tanifuji, Kazuya, Uga, Minori, Kawahara, Kota, Komiya, Aoi, Miura, Mizuki, Harada, Yamato, Hamaguchi, Yuki, Sasaki, Shohei, Shiozaki, Yuji, Kaneko, Ichiro, Miyamoto, Ken-ichi, Segawa, Hiroko

“…Phosphate (Pi)-containing food additives are used in several forms. Polyphosphate (PPi) salt has more harmful effects than monophosphate (MPi) salt on bone…”
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Regulation of renal phosphate handling: inter-organ communication in health and disease by Tatsumi, Sawako, Miyagawa, Atsumi, Kaneko, Ichiro, Shiozaki, Yuji, Segawa, Hiroko, Miyamoto, Ken-ichi

“…In this review, we focus on the interconnection of inorganic phosphate (Pi) homeostasis in the network of the bone–kidney, parathyroid–kidney,…”
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Regulation of Phosphate Transporters and Novel Regulator of Phosphate Metabolism by Koike, Megumi, Uga, Minori, Shiozaki, Yuji, Miyamoto, Ken-ichi, Segawa, Hiroko

“…Phosphorus is essential for all living organisms. It plays an important role in maintaining biological functions, such as energy metabolism, cell membrane…”
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The Role of Extracellular Phosphate Levels on Kidney Disease Progression in a Podocyte Injury Mouse Model by Maeda, Akira, Fukushima, Naoshi, Horiba, Naoshi, Segawa, Hiroko, Miyamoto, Ken-Ichi

“…Hyperphosphatemia is a major accelerator of complications in chronic kidney disease and dialysis, and phosphate (Pi) binders have been shown to regulate…”
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Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH by Maeda, Akira, Okazaki, Makoto, Baron, David M., Dean, Thomas, Khatri, Ashok, Mahon, Mathew, Segawa, Hiroko, Abou-Samra, Abdul B., Jüppner, Harald, Bloch, Kenneth D., Potts, John T., Gardella, Thomas J.

“…Agonist-induced phosphorylation of the parathyroid hormone (PTH) receptor 1 (PTHR1) regulates receptor signaling in vitro, but the role of this phosphorylation…”
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Control of phosphate balance by the kidney and intestine by Kaneko, Ichiro, Tatsumi, Sawako, Segawa, Hiroko, Miyamoto, Ken-ichi

“…The prevention and correction of hyperphosphatemia are major goals of the treatment of chronic kidney disease (CKD)-bone mineral disorders, and thus, Pi…”
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Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation by Fujii, Toru, Segawa, Hiroko, Hanazaki, Ai, Nishiguchi, Shiori, Minoshima, Sakura, Ohi, Akiko, Tominaga, Rieko, Sasaki, Sumire, Tanifuji, Kazuya, Koike, Megumi, Arima, Yuki, Shiozaki, Yuji, Kaneko, Ichiro, Ito, Mikiko, Tatsumi, Sawako, Miyamoto, Ken-ichi

“…Background Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc…”
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Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone Analogs by Nagai, So, Okazaki, Makoto, Segawa, Hiroko, Bergwitz, Clemens, Dean, Thomas, Potts, John T., Mahon, Matthew J., Gardella, Thomas J., Jüppner, Harald

“…The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTHR1) in cells of the renal proximal tubule mediates the reduction in membrane expression…”
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Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice by Segawa, Hiroko, Yamanaka, Setsuko, Ohno, Yasue, Onitsuka, Akemi, Shiozawa, Kazuyo, Aranami, Fumito, Furutani, Junya, Tomoe, Yuka, Ito, Mikiko, Kuwahata, Masashi, Imura, Akihiro, Nabeshima, Yoichi, Miyamoto, Ken-ichi

“…Recent studies have demonstrated that klotho protein plays a role in calcium/phosphate homeostasis. The goal of the present study was to investigate the…”
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Activation of a Non-cAMP/PKA Signaling Pathway Downstream of the PTH/PTHrP Receptor Is Essential for a Sustained Hypophosphatemic Response to PTH Infusion in Male Mice by Guo, Jun, Song, Lige, Liu, Minlin, Segawa, Hiroko, Miyamoto, Ken-Ichi, Bringhurst, F. Richard, Kronenberg, Henry M, Jüppner, Harald

“…PTH increases urinary Pi excretion by reducing expression of two renal cotransporters [NaPi-IIa (Npt2a) and NaPi-IIc (Npt2c)]. In contrast to acute transporter…”
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