Search Results - "Hiroki Osumi"

Clinical utility of circulating tumor DNA for colorectal cancer by Osumi, Hiroki, Shinozaki, Eiji, Yamaguchi, Kensei, Zembutsu, Hitoshi

“…Colorectal cancer (CRC) is currently the most common type of cancer in Japan, and its prognosis has improved because of development of diagnosis and…”
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Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma by Ooki, Akira, Osumi, Hiroki, Fukuda, Koshiro, Yamaguchi, Kensei

“…Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine differentiation, can arise in various organs. NENs have been divided into…”
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Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair by Ooki, Akira, Osumi, Hiroki, Yoshino, Koichiro, Yamaguchi, Kensei

“…Gastric cancer (GC) is a common malignancy that presents challenges in patient care worldwide. The mismatch repair (MMR) system is a highly conserved DNA…”
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Clinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer by Wakatsuki, Takeru, Yamamoto, Noriko, Sano, Takeshi, Chin, Keisho, Kawachi, Hiroshi, Takahari, Daisuke, Ogura, Mariko, Ichimura, Takashi, Nakayama, Izuma, Osumi, Hiroki, Matsushima, Tomohiro, Suenaga, Mitsukuni, Shinozaki, Eiji, Hiki, Naoki, Ishikawa, Yuichi, Yamaguchi, Kensei

“…Background There is growing interest in the clinical significance of intratumoral HER2 heterogeneity. Its prognostic and predictive impacts on trastuzumab…”
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Clinical impact of Epstein‐Barr virus status on the incidence of lymph node metastasis in early gastric cancer by Osumi, Hiroki, Kawachi, Hiroshi, Yoshio, Toshiyuki, Fujisaki, Junko

“…Epstein‐Barr virus‐positive gastric cancer (EBVGC) comprises approximately 9% of all gastric cancers and is associated with a low prevalence of lymph node…”
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Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma by Ooki, Akira, Osumi, Hiroki, Chin, Keisho, Watanabe, Masayuki, Yamaguchi, Kensei

“…Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a…”
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Changes in the neutrophil-to-lymphocyte ratio during nivolumab monotherapy are associated with gastric cancer survival by Ota, Yumiko, Takahari, Daisuke, Suzuki, Takeshi, Osumi, Hiroki, Nakayama, Izuma, Oki, Akira, Wakatsuki, Takeru, Ichimura, Takashi, Ogura, Mariko, Shinozaki, Eiji, Suenaga, Mitsukuni, Chin, Keisho, Yamaguchi, Kensei

“…Purpose In the ATTRACTION-2 trial, nivolumab significantly improved the survival of advanced gastric cancer patients. The pretreatment neutrophil-to-lymphocyte…”
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Risk stratification for lymph node metastasis using Epstein–Barr virus status in submucosal invasive (pT1) gastric cancer without lymphovascular invasion: a multicenter observational study by Osumi, Hiroki, Kawachi, Hiroshi, Murai, Katsuyuki, Kusafuka, Kimihide, Inoue, Shuntaro, Kitamura, Masaki, Yoshio, Toshiyuki, Kakusima, Naomi, Ishihara, Ryu, Ono, Hiroyuki, Yamamoto, Noriko, Sugino, Takashi, Nakatsuka, Shinichi, Ida, Satoshi, Nunobe, Souya, Bando, Etsuro, Omori, Takeshi, Takeuchi, Kengo, Fujisaki, Junko

“…Background Lymphovascular invasion (LVI) is a strong predictive factor for lymph node metastasis (LNM) in early gastric cancer (GC). This study investigated…”
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Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research by Takahari, Daisuke, Shinozaki, Eiji, Wakatsuki, Takeru, Ooki, Akira, Ozaka, Masato, Suzuki, Takeshi, Nakayama, Izuma, Osumi, Hiroki, Kamiimabeppu, Daisaku, Sato, Taro, Ogura, Mariko, Suenaga, Mitsukuni, Chin, Keisho, Yamaguchi, Kensei

“…Coronavirus disease 2019 (COVID-19) was declared to be a global pandemic by the World Health Organization on March 11, 2020. On April 7, 2020, a state of…”
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Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer by Yagi, Shusuke, Wakatsuki, Takeru, Yamamoto, Noriko, Chin, Keisho, Takahari, Daisuke, Ogura, Mariko, Ichimura, Takashi, Nakayama, Izuma, Osumi, Hiroki, Shinozaki, Eiji, Suenaga, Mitsukuni, Fujisaki, Junko, Ishikawa, Yuichi, Yamaguchi, Kensei, Namikawa, Ken, Horiuchi, Yusuke

“…Background We recently reported the clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using surgical specimens; patients with…”
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Clinical features associated with NeoRAS wild-type metastatic colorectal cancer A SCRUM-Japan GOZILA substudy by Osumi, Hiroki, Shinozaki, Eiji, Nakamura, Yoshiaki, Esaki, Taito, Yasui, Hisateru, Taniguchi, Hiroya, Satake, Hironaga, Sunakawa, Yu, Komatsu, Yoshito, Kagawa, Yoshinori, Denda, Tadamichi, Shiozawa, Manabu, Satoh, Taroh, Nishina, Tomohiro, Goto, Masahiro, Takahashi, Naoki, Kato, Takeshi, Bando, Hideaki, Yamaguchi, Kensei, Yoshino, Takayuki

“…“Neo RAS WT” refers to the loss of RAS mutations (MTs) following first-line treatment in metastatic colorectal cancer (mCRC). We evaluate the incidence and…”
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Neoadjuvant Chemoradiotherapy with Cisplatin Plus Fluorouracil for Borderline Resectable Esophageal Squamous Cell Carcinoma by Suzuki, Takeshi, Okamura, Akihiko, Watanabe, Masayuki, Mine, Shinji, Imamura, Yu, Asari, Takao, Osumi, Hiroki, Nakayama, Izuma, Ichimura, Takashi, Ogura, Mariko, Ooki, Akira, Takahari, Daisuke, Yamaguchi, Kensei, Chin, Keisho

“…Background The optimal treatment strategy for patients with borderline resectable (BR) esophageal squamous cell carcinoma (ESCC), in which tumors grow very…”
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KRAS mutation as a predictor of insufficient trastuzumab efficacy and poor prognosis in HER2-positive advanced gastric cancer by Shimozaki, Keitaro, Shinozaki, Eiji, Yamamoto, Noriko, Imamura, Yu, Osumi, Hiroki, Nakayama, Izuma, Wakatsuki, Takeru, Ooki, Akira, Takahari, Daisuke, Ogura, Mariko, Chin, Keisho, Watanabe, Masayuki, Yamaguchi, Kensei

“…Purpose Although RAS and PIK3CA mutations have been associated with resistance to anti-EGFR antibody in colorectal cancer or trastuzumab in breast cancer,…”
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A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication by Osumi, Hiroki, Fujisaki, Junko, Suganuma, Takanori, Horiuchi, Yusuke, Omae, Masami, Yoshio, Toshiyuki, Ishiyama, Akiyoshi, Tsuchida, Tomohiro, Miki, Kazumasa

“…Helicobacter pylori (H. pylori) eradication is usually assessed using the 13C-urea breath test (UBT), anti-H. pylori antibody and the H. pylori stool antigen…”
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Non‐V600E BRAF mutations and EGFR signaling pathway in colorectal cancer by Osumi, Hiroki, Shinozaki, Eiji, Wakatsuki, Takeru, Suenaga, Mitsukuni, Ichimura, Takashi, Ogura, Mariko, Takahari, Daisuke, Ooki, Akira, Suzuki, Takeshi, Ota, Yumiko, Nakayama, Izuma, Chin, Keisho, Miki, Yoshio, Yamaguchi, Kensei

“…The Raf murine sarcoma viral oncogene homolog B (BRAFV600E) mutation (MT) in metastatic colorectal cancer (CRC) is a well‐known prognostic indicator and a…”
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Single-organ pulmonary metastasis is a favorable prognostic factor in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors by Fukuda, Koshiro, Osumi, Hiroki, Yoshino, Koichiro, Nakayama, Izuma, Fukuoka, Shota, Ogura, Mariko, Wakatsuki, Takeru, Ooki, Akira, Takahari, Daisuke, Chin, Keisho, Yamaguchi, Kensei, Shinozaki, Eiji

“…Few studies have focused on the impact of single-organ pulmonary metastases on progression-free survival and overall survival in patients with metastatic…”
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Epstein–Barr virus status is a promising biomarker for endoscopic resection in early gastric cancer: proposal of a novel therapeutic strategy by Osumi, Hiroki, Kawachi, Hiroshi, Yoshio, Toshiyuki, Ida, Satoshi, Yamamoto, Noriko, Horiuchi, Yusuke, Ishiyama, Akiyoshi, Hirasawa, Toshiaki, Tsuchida, Tomohiro, Hiki, Naoki, Takeuchi, Kengo, Fujisaki, Junko

“…Background Epstein–Barr virus-positive gastric cancer (EBVGC) is associated with a low prevalence of lymph node metastasis (LNM); however, EBV status is not…”
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Multicentre single-arm phase II trial evaluating the safety and effiCacy of Panitumumab and iRinOtecan in NeoRAS Wild-type mEtaStatic colorectal cancer patientS (C-PROWESS trial): study protocol by Osumi, Hiroki, Ishizuka, Naoki, Takashima, Atsuo, Kumekawa, Yosuke, Nakano, Daisuke, Shiozawa, Manabu, Denda, Tadamichi, Sawada, Ryoichi, Ouchi, Kota, Wakatsuki, Takeru, Narikazu, Boku, Kato, Ken, Yamaguchi, Kensei, Shinozaki, Eiji

“…IntroductionA new concept of ‘NeoRAS wild-type (WT)’, which means conversion of RAS status from RAS mutant to RAS WT after treatment, has been reported…”
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Phase II trial of biweekly cetuximab and irinotecan as third‐line therapy for pretreated KRAS exon 2 wild‐type colorectal cancer by Osumi, Hiroki, Shinozaki, Eiji, Mashima, Tetsuo, Wakatsuki, Takeru, Suenaga, Mitsukuni, Ichimura, Takashi, Ogura, Mariko, Ota, Yumiko, Nakayama, Izuma, Takahari, Daisuke, Chin, Keisho, Miki, Yoshio, Yamaguchi, Kensei

“…Efficacy and safety of biweekly cetuximab plus irinotecan were evaluated to provide guidance for its use in Japan as third‐line treatment for pretreated…”
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Clinical outcomes of radical gastrectomy following trastuzumab-based chemotherapy for stage IV HER2-positive gastric or gastroesophageal junction cancer by Takahashi, Ryo, Nunobe, Souya, Osumi, Hiroki, Takahari, Daisuke, Yamamoto, Noriko, Ida, Satoshi, Kumagai, Koshi, Ohashi, Manabu, Sano, Takeshi, Hiki, Naoki

“…Purpose Patients who receive trastuzumab (T-mab) plus chemotherapy for stage IV HER2-positive gastric or gastroesophageal junction cancer sometimes respond…”
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