Search Results - "Hiroki, J"

Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction by Han, Han, Qi, Ruxi, Zhou, Jeff Jiajing, Ta, Albert Paul, Yang, Bing, Nakaoka, Hiroki J., Seo, Gayoung, Guan, Kun-Liang, Luo, Ray, Wang, Wenqi

“…The Hippo pathway plays a crucial role in organ size control and tumor suppression, but its precise regulation is not fully understood. In this study, we…”
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Loss of YAP1 defines neuroendocrine differentiation of lung tumors by Ito, Takeshi, Matsubara, Daisuke, Tanaka, Ichidai, Makiya, Kanae, Tanei, Zen‐ichi, Kumagai, Yuki, Shiu, Shu‐Jen, Nakaoka, Hiroki J., Ishikawa, Shumpei, Isagawa, Takayuki, Morikawa, Teppei, Shinozaki‐Ushiku, Aya, Goto, Yasushi, Nakano, Tomoyuki, Tsuchiya, Takehiro, Tsubochi, Hiroyoshi, Komura, Daisuke, Aburatani, Hiroyuki, Dobashi, Yoh, Nakajima, Jun, Endo, Shunsuke, Fukayama, Masashi, Sekido, Yoshitaka, Niki, Toshiro, Murakami, Yoshinori

“…YAP1, the main Hippo pathway effector, is a potent oncogene and is overexpressed in non‐small‐cell lung cancer (NSCLC); however, the YAP1 expression pattern in…”
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Hippo signaling dysfunction induces cancer cell addiction to YAP by Han, Han, Yang, Bing, Nakaoka, Hiroki J, Yang, Jiadong, Zhao, Yifan, Le Nguyen, Kathern, Bishara, Amell Taffy, Mandalia, Tejas Krishen, Wang, Wenqi

“…Over the past decades, the Hippo has been established as a crucial pathway involved in organ size control and cancer suppression. Dysregulation of Hippo…”
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Defining the ATPome reveals cross-optimization of metabolic pathways by Bennett, Neal K., Nguyen, Mai K., Darch, Maxwell A., Nakaoka, Hiroki J., Cousineau, Derek, ten Hoeve, Johanna, Graeber, Thomas G., Schuelke, Markus, Maltepe, Emin, Kampmann, Martin, Mendelsohn, Bryce A., Nakamura, Jean L., Nakamura, Ken

“…Disrupted energy metabolism drives cell dysfunction and disease, but approaches to increase or preserve ATP are lacking. To generate a comprehensive metabolic…”
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Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function by Bennett, Neal K, Nakaoka, Hiroki J, Laurent, Danny, Okimoto, Ross A, Sei, Yoshitaka, Horvai, Andrew E, Bivona, Trever G, Ten Hoeve, Johanna, Graeber, Thomas G, Nakamura, Ken, Nakamura, Jean L

“…The Warburg effect, aerobic glycolysis, is a hallmark feature of cancer cells grown in culture. However, the relative roles of glycolysis and respiratory…”
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Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes by Hara, Toshiro, Nakaoka, Hiroki J., Hayashi, Tetsuro, Mimura, Kouhei, Hoshino, Daisuke, Inoue, Masahiro, Nagamura, Fumitaka, Murakami, Yoshinori, Seiki, Motoharu, Sakamoto, Takeharu

“…Cancer metastasis is intricately orchestrated by both cancer and normal cells, such as endothelial cells and macrophages. Monocytes/macrophages, which are…”
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The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1 by Han, Han, Nakaoka, Hiroki J., Hofmann, Line, Zhou, Jeff Jiajing, Yu, Clinton, Zeng, Lisha, Nan, Junyu, Seo, Gayoung, Vargas, Rebecca Elizabeth, Yang, Bing, Qi, Ruxi, Bardwell, Lee, Fishman, Dmitry A., Cho, Ken W. Y., Huang, Lan, Luo, Ray, Warrior, Rahul, Wang, Wenqi

“…Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and various…”
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Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus by Uematsu, Takayuki, Fujita, Tomoko, Nakaoka, Hiroki J., Hara, Toshiro, Kobayashi, Noritada, Murakami, Yoshinori, Seiki, Motoharu, Sakamoto, Takeharu

“…Influenza virus (IFV) infection is a common cause of severe pneumonia. Studies have suggested that excessive activation of the host immune system including…”
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NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells by Nakaoka, Hiroki J., Hara, Toshiro, Yoshino, Seiko, Kanamori, Akane, Matsui, Yusuke, Shimamura, Teppei, Sato, Hiroshi, Murakami, Yoshinori, Seiki, Motoharu, Sakamoto, Takeharu

“…Unlike most cells, cancer cells activate hypoxia inducible factor-1 (HIF-1) to use glycolysis even at normal oxygen levels, or normoxia. Therefore, HIF-1 is an…”
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The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux by Yoshino, Seiko, Hara, Toshiro, Nakaoka, Hiroki J, Kanamori, Akane, Murakami, Yoshinori, Seiki, Motoharu, Sakamoto, Takeharu

“…Loss of anchorage to the extracellular matrix leads to apoptosis (anoikis) in normal cells, but cancerous cells are usually resistant to such stress. Here we…”
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Nf1 -Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK by Pucciarelli, Daniela, Angus, Steven P, Huang, Benjamin, Zhang, Chi, Nakaoka, Hiroki J, Krishnamurthi, Ganesh, Bandyopadhyay, Sourav, Clapp, D Wade, Shannon, Kevin, Johnson, Gary L, Nakamura, Jean L

“…Loss of the tumor suppressor leads to activation of RAS effector pathways, which are therapeutically targeted by inhibition of mTOR (mTORi) or MEK (MEKi)…”
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Loss of YAP 1 defines neuroendocrine differentiation of lung tumors by Ito, Takeshi, Matsubara, Daisuke, Tanaka, Ichidai, Makiya, Kanae, Tanei, Zen‐ichi, Kumagai, Yuki, Shiu, Shu‐Jen, Nakaoka, Hiroki J., Ishikawa, Shumpei, Isagawa, Takayuki, Morikawa, Teppei, Shinozaki‐Ushiku, Aya, Goto, Yasushi, Nakano, Tomoyuki, Tsuchiya, Takehiro, Tsubochi, Hiroyoshi, Komura, Daisuke, Aburatani, Hiroyuki, Dobashi, Yoh, Nakajima, Jun, Endo, Shunsuke, Fukayama, Masashi, Sekido, Yoshitaka, Niki, Toshiro, Murakami, Yoshinori

“…YAP 1 , the main Hippo pathway effector, is a potent oncogene and is overexpressed in non‐small‐cell lung cancer ( NSCLC ); however, the YAP 1 expression…”
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Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension by Mukai, Y, Shimokawa, H, Matoba, T, Kandabashi, T, Satoh, S, Hiroki, J, Kaibuchi, K, Takeshita, A

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The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1 by Han, Han, Nakaoka, Hiroki J, Hofmann, Line, Zhou, Jeff Jiajing, Yu, Clinton, Zeng, Lisha, Nan, Junyu, Seo, Gayoung, Vargas, Rebecca Elizabeth, Yang, Bing, Qi, Ruxi, Bardwell, Lee, Fishman, Dmitry A., Cho, Ken W.Y., Huang, Lan, Luo, Ray, Warrior, Rahul, Wang, Wenqi

“…Heavy metals are both integral parts of cells and environmental toxicants, whose deregulation is associated with severe cellular dysfunction and various…”
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Nf1 mutant tumors undergo transcriptome and kinome re-modeling after inhibition of either mTOR or MEK by Pucciarelli, Daniela, Angus, Steven P., Huang, Benjamin, Zhang, Chi, Nakaoka, Hiroki J., Krishnamurthi, Ganesh, Bandyopadhyay, Sourav, Clapp, D. Wade, Shannon, Kevin, Johnson, Gary L., Nakamura, Jean L.

“…Loss of the tumor suppressor NF1 leads to activation of RAS effector pathways, which are therapeutically targeted by inhibition of mTOR (mTORi) or MEK (MEKi)…”
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Long-Term Inhibition of Rho-Kinase Suppresses Angiotensin II–Induced Cardiovascular Hypertrophy in Rats In Vivo: Effect on Endothelial NAD(P)H Oxidase System by Higashi, Midoriko, Shimokawa, Hiroaki, Hattori, Tsuyoshi, Hiroki, Junko, Mukai, Yasushi, Morikawa, Keiko, Ichiki, Toshihiro, Takahashi, Shosuke, Takeshita, Akira

“…ABSTRACT—Intracellular signaling pathway mediated by small GTPase Rho and its effector Rho-kinase plays an important role in regulation of vascular smooth…”
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P6154Association between n-3 and n-6 polyunsaturated fatty acids and plaque vulnerability by optical coherence tomography in acute myocardial infarction patients by Kanehama, N, Kimura, S, Kawakami, T, Tateishi, R, Tachibana, S, Hayasaka, K, Arai, H, Hiroki, J, Yoshioka, K, Kuroda, S, Ueshima, D, Iwatsuka, R, Hayashi, T, Mizukami, A, Matsumura, A

“…Abstract Background The values of n-3 and n-6 polyunsaturated fatty acids (PUFAs) like low eicosapentaenoic acid (EPA) /arachidonic acid (AA) ratio are known…”
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Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase by TAKEMOTO, Masao, JIANXIN SUN, HIROKI, Junko, SHIMOKAWA, Hiroaki, LIAO, James K

“…Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing…”
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P5502Comparison of accuracy of fractional flow reserve using optical sensor wire to conventional pressure wire by Tateishi, R, Kimura, S, Kawakami, T, Kanehama, N, Tachibana, S, Arai, H, Hayasaka, K, Hara, S, Hiroki, J, Yoshioka, K, Kuroda, S, Iwatsuka, R, Mizukami, A, Hayashi, T, Matsumura, A

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P2629Reliability of optical coherence tomography in the prediction of occurrence of side-branch complications after percutaneous coronary intervention by Kimura, S, Kawakami, T, Kanehama, N, Tateishi, R, Tachibana, S, Arai, H, Hara, S, Hayasaka, K, Hiroki, J, Yoshioka, K, Kuroda, S, Iwatsuka, R, Mizukami, A, Hayashi, T, Matsumura, A

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