Search Results - "Hirokawa, K."

Immunology of Aging: the Birth of Inflammaging by Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., Franceschi, C.

“…The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes…”
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Immunosenescence is both functional/adaptive and dysfunctional/maladaptive by Fulop, T., Larbi, A., Hirokawa, K., Cohen, A. A., Witkowski, J. M.

“…Alterations in the immune system with aging are considered to underlie many age-related diseases. However, many elderly individuals remain healthy until even a…”
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Altered T cell signalling in ageing by Pawelec, Graham, Hirokawa, Katsuiku, Fülöp, Tàmas

“…T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against…”
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Associations of menstrual pain with intakes of soy, fat and dietary fiber in Japanese women by Nagata, C, Hirokawa, K, Shimizu, N, Shimizu, H

“…Objective: Intakes of soy, fat, and dietary fiber may be associated with the symptoms of dysmenorrhea through their biological effects on estrogens or…”
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Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes by KITAGAWA, M, SAITO, I, KUWATA, T, YOSHIDA, S, YAMAGUCHI, S, TAKAHASHI, M, TANIZAWA, T, KAMIYAMA, R, HIROKAWA, K

“…To clarify whether regulatory cytokines inhibit hematopoiesis in patients with myelodysplastic syndromes (MDS), malignancies characterized by the formation of…”
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Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes by Sawanobori, Masakazu, Yamaguchi, Shuichi, Hasegawa, Maki, Inoue, Miori, Suzuki, Kenshi, Kamiyama, Ryuichi, Hirokawa, Katsuiku, Kitagawa, Masanobu

“…Myelodysplastic syndromes (MDS) are characterized by peripheral blood cytopenias despite hypercellularity of the bone marrow regarded as the result of…”
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Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia by KITAGWA, M, YAMAGUCHI, S, TAKAHASHI, M, TANIZAWA, T, HIROKAWA, K, KAMIYAMA, R

“…Frequent apoptosis in the bone marrow of patients with myelodysplastic syndromes (MDS) was demonstrated on frozen sections using the terminal deoxytransferase…”
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Animal models and possible human application of immunological restoration in the elderly by Hirokawa, K., Utsuyama, M.

“…Autopsy reports by pathologists in geriatric hospitals reveal that the leading direct cause of death in the elderly over 65 years of age are infectious…”
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Expression of IAP family proteins in colon cancers from patients with different age groups by ENDO, T, ABE, S, SEIDLAR, H. B. K, NAGAOKA, S, TAKEMURA, T, UTSUYAMA, M, KITAGAWA, M, HIROKAWA, K

“…Members of the inhibitor of apoptosis protein (IAP) family including survivin, are expressed in many tumors. However, age-related changes in their expression…”
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Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta by IKEDA, T, SHIRASAWA, T, ESAKI, Y, YOSHIKI, S, HIROKAWA, K

“…Osteopontin is a phosphorylated, sialic acid-rich, noncollagenous bone matrix protein containing the Arg-Gly-Asp-Ser amino acid sequence responsible for cell…”
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Adenoviral Transfer of Cyclin-Dependent Kinase Inhibitor Genes Suppresses Collagen-Induced Arthritis in Mice by Nasu, Kimio, Kohsaka, Hitoshi, Nonomura, Yoshinori, Terada, Yoshio, Ito, Hiroshi, Hirokawa, Katsuiku, Miyasaka, Nobuyuki

“…In rheumatoid synovial tissues, synovial fibroblasts are activated by proinflammatory cytokines and proliferate to develop hyperplastic pannus tissues, which…”
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Recombinant Agrobacterium AgaE-like protein with fructosyl amino acid oxidase activity by Hirokawa, K. (Kikkoman Corp., Noda, Chiba (Japan)), Kajiyama, N

“…Agrobacterium tumefaciens AgaE-like protein had a similar sequence to that of a fructosyl amino acid oxidase from Corynebacterium sp. strain 2-4-1. To…”
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Age-related decline of brain monoamines in mice is reversed to young level by Japanese herbal medicine by Tsunemi, A, Utsuyama, M, Seidler, B K H, Kobayashi, S, Hirokawa, K

“…Young (3-month-old) and aged mice (18-month-old) were fed a diet containing Japanese herbal medicine (TJ-41 or TJ-48) for 5 months, and the effect of the…”
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Induction of immunological tolerance by oral, but not intravenous and intraportal, administration of ovalbumin and the difference between young and old mice by Wakabayashi, A, Utsuyama, M, Hosoda, T, Sato, K, Takahashi, H, Hirokawa, K

“…Induction of immunological tolerance is dependent on the route of antigenic administration, the dose of an antigen and the age of animals. We investigated the…”
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Expression of Protein Tyrosine Phosphatases and Its Significance in Esophageal Cancer by Warabi, M., Nemoto, T., Ohashi, K., Kitagawa, M., Hirokawa, K.

“…Expression of mRNA protein tyrosine phosphatases (PTPs) was surveyed in an esophageal cancer cell line by RT-PCR using degenerate primers. The mRNAs for eight…”
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Unexpected clinicopathological phenotype linked to small elongation of CAG repeat in SCA1 gene by Uchihara, T, Takeda, Y, Kobayashi, T, Kasuga, T, Ishikawa, K, Kirei, K, Mizusawa, H, Endo, T, Hirokawa, K, Kuroiwa, T

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Hypothalamic control of thymic function by Hirokawa, K, Utsuyama, M, Kobayashi, S

“…Removal of the pituitary gland results in atrophy of the thymus. As the former is under the control of hypothalamus, destruction of anterior portion of the…”
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Clinical pharmacologists and drug regulation—future perspective in Japan by HIROKAWA, K.

“…1The Japanese pharmaceutical administration system, and recommendations for the improvement of clinical trial methodology following the implementation of GCP…”
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Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia by Abe, S., Yamamoto, K., Hasegawa, M., Inoue, M., Kurata, M., Hirokawa, K., Kitagawa, M., Nakagawa, Y., Suzuki, K.

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Research on biomedical gerontology in Japan by Hirokawa, K, Goto, S

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