Search Results - "Hiratochi, Masahiro"

Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level by Katsuno, Kenji, Fujimori, Yoshikazu, Takemura, Yukiko, Hiratochi, Masahiro, Itoh, Fumiaki, Komatsu, Yoshimitsu, Fujikura, Hideki, Isaji, Masayuki

“…The low-affinity sodium glucose cotransporter (SGLT2), which is expressed specifically in the kidney, plays a major role in renal glucose reabsorption in the…”
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Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout by Tatani, Kazuya, Hiratochi, Masahiro, Kikuchi, Norihiko, Kuramochi, Yu, Watanabe, Shinjiro, Yamauchi, Yuji, Itoh, Fumiaki, Isaji, Masayuki, Shuto, Satoshi

“…To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary…”
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Identification of 8‑Aminoadenosine Derivatives as a New Class of Human Concentrative Nucleoside Transporter 2 Inhibitors by Tatani, Kazuya, Hiratochi, Masahiro, Nonaka, Yoshinori, Isaji, Masayuki, Shuto, Satoshi

“…Purine-rich foods have long been suspected as a major cause of hyperuricemia. We hypothesized that inhibition of human concentrative nucleoside transporter 2…”
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The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis by Nakayama, Kohzo, Ohkawara, Takeshi, Hiratochi, Masahiro, Koh, Chang-Sung, Nagase, Hisashi

“…Although amyloid precursor protein (APP) has central roles in Alzheimer's disease, the physiological functions of this protein have yet to be fully elucidated…”
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Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins by Nakayama, Kohzo, Nagase, Hisashi, Hiratochi, Masahiro, Koh, Chang-Sung, Ohkawara, Takeshi

“…In the canonical Notch signaling pathway, intramembrane cleavage by gamma-secretase serves to release an intracellular domain of Notch that has activity in the…”
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Multiple POU-binding motifs, recognized by tissue-specific nuclear factors, are important for Dll1 gene expression in neural stem cells by Nakayama, Kohzo, Nagase, Kazuko, Tokutake, Yuriko, Koh, Chang-Sung, Hiratochi, Masahiro, Ohkawara, Takeshi, Nakayama, Noriko

“…We cloned the 5′-flanking region of the mouse homolog of the Delta gene (Dll1) and demonstrated that the sequence between nucleotide position −514 and −484 in…”
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Participation of thromboxane A2 in the cough response in guinea‐pigs: antitussive effect of ozagrel by Shinagawa, Kazuhiko, Kojima, Masami, Ichikawa, Kiyoshi, Hiratochi, Masahiro, Aoyagi, Shigemi, Akahane, Masuo

“…The purpose of this study was to investigate the involvement of thromboxane A2 (TXA2) in the cough response in a guinea‐pig cough model. Here, we describe…”
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Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor by Shimizu, Kazuo, Fujikura, Hideki, Fushimi, Nobuhiko, Nishimura, Toshihiro, Tatani, Kazuya, Katsuno, Kenji, Fujimori, Yoshikazu, Watanabe, Shinjiro, Hiratochi, Masahiro, Nakabayashi, Takeshi, Kamada, Noboru, Arakawa, Koichi, Hikawa, Hidemasa, Azumaya, Isao, Isaji, Masayuki

“…[Display omitted] We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to…”
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Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions by Tsuchioka, Akihiro, Oana, Fumiki, Suzuki, Takayuki, Yamauchi, Yuji, Ijiro, Tomoyuki, Kaidoh, Kouichi, Hiratochi, Masahiro

“…Although 6-hydroxydopamine-induced (6-OHDA-induced) rats are a well-known Parkinson’s disease model, the effects of dopamine D2 agonists in mice with…”
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The Delta intracellular domain mediates TGF-β/Activin signaling through binding to Smads and has an important bi-directional function in the Notch–Delta signaling pathway by Hiratochi, Masahiro, Nagase, Hisashi, Kuramochi, Yu, Koh, Chang-Sung, Ohkawara, Takeshi, Nakayama, Kohzo

“…Delta is a major transmembrane ligand for Notch receptor that mediates numerous cell fate decisions. The Notch signaling pathway has long been thought to be…”
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Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides by Hiratochi, Masahiro, Tatani, Kazuya, Shimizu, Kazuo, Kuramochi, Yu, Kikuchi, Norihiko, Kamada, Noboru, Itoh, Fumiaki, Isaji, Masayuki

“…We have developed concentrative nucleoside transporter 2 (CNT2) inhibitors as a novel pharmacological approach for improving hyperuricemia by inhibiting…”
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SLC5A9/SGLT4, a new Na +-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose by Tazawa, Shigeki, Yamato, Tokuhisa, Fujikura, Hideki, Hiratochi, Masahiro, Itoh, Fumiaki, Tomae, Masaki, Takemura, Yukiko, Maruyama, Hidetoshi, Sugiyama, Tomoyasu, Wakamatsu, Ai, Isogai, Takao, Isaji, Masayuki

“…We isolated a cDNA clone of SLC5A9/SGLT4 from human small intestinal full-length cDNA libraries, and functionally characterized it in vitro. The messenger RNA…”
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Morphogenic activity of fibroblast growth factor‐2 on primary neural precursor cells in three‐dimensional culture by Hiratochi, Masahiro, Fujiwara, Akiyori, Kitani, Hiroshi, Iguchi, Taisen, Sakakura, Teruyo, Tomooka, Yasuhiro

“…Mouse neural precursor cells (NPC) were dissociated from fetal heads at the 10th day of gestation. When clumps of NPC were cultured in collagen gel, they grew…”
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Function and expression differences between ergot and non-ergot dopamine D2 agonists on heart valve interstitial cells by Oana, Fumiki, Onozuka, Hiroshi, Tsuchioka, Akihiro, Suzuki, Takayuki, Tanaka, Nobuyuki, Kaidoh, Kouichi, Hoyano, Yuji, Hiratochi, Masahiro, Kikuchi, Shinji, Takehana, Yasuo, Shibata, Nobuo

“…The symptoms of Parkinson's disease are alleviated by dopamine D2 agonists, which are classified as ergot dopamine D2 agonists and non-ergot D2 agonists. Among…”
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Participation of thromboxane A 2 in the cough response in guinea‐pigs: antitussive effect of ozagrel by Shinagawa, Kazuhiko, Kojima, Masami, Ichikawa, Kiyoshi, Hiratochi, Masahiro, Aoyagi, Shigemi, Akahane, Masuo

“…The purpose of this study was to investigate the involvement of thromboxane A 2 (TXA 2 ) in the cough response in a guinea‐pig cough model. Here, we describe…”
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Corrigendum to “SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro- d-glucitol, and fructose” [Life Sciences 76 (2005) 1039–1050] by Tazawa, Shigeki, Yamato, Tokuhisa, Fujikura, Hideki, Hiratochi, Masahiro, Itoh, Fumiaki, Tomae, Masaki, Takemura, Yukiko, Maruyama, Hidetoshi, Sugiyama, Tomoyasu, Wakamatsu, Ai, Isogai, Takao, Isaji, Masayuki

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The Delta intracellular domain mediates TGF-[beta]/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway by Hiratochi, Masahiro, Nagase, Hisashi, Yu Kuramochi, Chang-Sung, Koh, Ohkawara, Takeshi, Nakayama, Kohzo

“…Delta is a major transmembrane ligand for Notch receptor that mediates numerous cell fate decisions. The Notch signaling pathway has long been thought to be…”
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Inhibition of interleukin 5 production with no influence on interleukin 4 production by an anti-allergic drug, tranilast, in Toxocara canis-infected mice by Hiratochi, Masahiro, Takamoto, Masaya, Tatemichi, Satoshi, Sugane, Kazuo

“…Tranilast is well-known as a useful drug for allergic diseases. This drug is believed to exhibit its therapeutic effects by inhibiting the release of chemical…”
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