Search Results - "Hirata, Yuichiro"

In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir by Kiso, Maki, Yamayoshi, Seiya, Iida, Shun, Furusawa, Yuri, Hirata, Yuichiro, Uraki, Ryuta, Imai, Masaki, Suzuki, Tadaki, Kawaoka, Yoshihiro

“…Ensitrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro or Nsp5), is clinically useful against SARS-CoV-2 including its omicron…”
Get full text

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters by Furusawa, Yuri, Kiso, Maki, Iida, Shun, Uraki, Ryuta, Hirata, Yuichiro, Imai, Masaki, Suzuki, Tadaki, Yamayoshi, Seiya, Kawaoka, Yoshihiro

“…The SARS-CoV-2 delta (B.1.617.2 lineage) variant was first identified at the end of 2020 and possessed two unique amino acid substitutions in its spike…”
Get full text

Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats by Yang, Chihpin, Sugimoto, Kana, Murata, Yukie, Hirata, Yuichiro, Kamakura, Yu, Koyama, Yoshihisa, Miyashita, Yohei, Nakama, Kentaro, Higashisaka, Kazuma, Harada, Kazuo, Katada, Ryuichi, Matsumoto, Hiroshi

“…Numerous dark-brown-coloured small spots called “Wischnewski spots” are often observed in the gastric mucosa in the patients dying of hypothermia, but the…”
Get full text

Changes in SARS-CoV-2 viral load and titers over time in SARS-CoV-2-infected human corpses by Nagasawa, Sayaka, Hirata, Yuichiro, Miyamoto, Sho, Ozono, Seiya, Iida, Shun, Katano, Harutaka, Tsuneya, Shigeki, Kira, Kei, Kobayashi, Susumu, Nakajima, Makoto, Abe, Hiroyuki, Ikemura, Masako, Yamamoto, Isao, Nakagawa, Kimiko, Kubota, Kazumi, Akitomi, Shinji, Hasegawa, Iwao, Ushiku, Tetsuo, Suzuki, Tadaki, Iwase, Hirotaro, Makino, Yohsuke, Saitoh, Hisako

“…High viral titers of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been detected in human corpses long after death. However,…”
Get full text

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates by Uraki, Ryuta, Iida, Shun, Halfmann, Peter J., Yamayoshi, Seiya, Hirata, Yuichiro, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Ito, Mutsumi, Furusawa, Yuri, Ueki, Hiroshi, Sakai-Tagawa, Yuko, Kuroda, Makoto, Maemura, Tadashi, Kim, Taksoo, Mine, Sohtaro, Iwamoto, Noriko, Li, Rong, Liu, Yanan, Larson, Deanna, Fukushi, Shuetsu, Watanabe, Shinji, Maeda, Ken, Wang, Zhongde, Ohmagari, Norio, Theiler, James, Fischer, Will, Korber, Bette, Imai, Masaki, Suzuki, Tadaki, Kawaoka, Yoshihiro

“…The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological…”
Get full text

Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids by Kuwano, Tetsuya, Kanno, Takayuki, Tobiume, Minoru, Hirata, Yuichiro, Katano, Harutaka, Koga, Michiko, Nagai, Hiroyuki, Tsutsumi, Takeya, Yoshikawa, Noritada, Yotsuyanagi, Hiroshi, Kutsuna, Satoshi, Miyazato, Yusuke, Kinoshita-Iwamoto, Noriko, Ohmagari, Norio, Kobayashi, Taiichiro, Fukushima, Kazuaki, Tanaka, Masaru, Imamura, Akifumi, Ueda, Yui, Iwamura, Maeko, Takada, Naoto, Inoue, Takayoshi, Matano, Tetsuro, Kawana-Tachikawa, Ai, Suzuki, Tadaki

“…There have been several reports of skin manifestations in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether severe acute…”
Get full text

Activation of the AKT Pathway in the Ascending Aorta With Bicuspid Aortic Valve by Hirata, Yuichiro, Aoki, Hiroki, Shojima, Takahiro, Takagi, Kazuyoshi, Takaseya, Tohru, Akasu, Kohji, Tobinaga, Satoru, Fukumoto, Yoshihiro, Tanaka, Hiroyuki

“…Background: Dilatation of the ascending aorta affects those patients with bicuspid aortic valve (BAV), even after valvular surgery, possibly due to tissue…”
Get full text

The earliest enzyme replacement for infantile‐onset Pompe disease in Japan by Tocan, Vlad, Mushimoto, Yuichi, Kojima‐Ishii, Kanako, Matsuda, Akane, Toda, Naoko, Toyomura, Daisuke, Hirata, Yuichiro, Sanefuji, Masafumi, Sawada, Takaaki, Sakai, Yasunari, Nakamura, Kimitoshi, Ohga, Shouichi

“…Background Infantile‐onset Pompe disease (IOPD) is the most severe phenotype of a lysosomal storage disorder caused by acid alpha‐glucosidase (GAA) deficiency…”
Get full text

Portosystemic venous shunt in the patients with Fontan circulation by Nagata, Hazumu, Sakamoto, Ichiro, Fukuoka, Shouji, Ishikita, Ayako, Uike, Kiyoshi, Nagatomo, Yusaku, Hirata, Yuichiro, Yamamura, Kenichiro, Ohga, Shouichi

“…Portosystemic venous shunt (PSVS) is a vascular anomaly between the portal and systemic veins, resulting in several critical complications. Although PSVS is…”
Get full text

Impact of the COVID‐19 pandemic on pathological autopsy practices in Japan by Hirata, Yuichiro, Iida, Shun, Arashiro, Takeshi, Nagasawa, Sayaka, Saitoh, Hisako, Abe, Hiroyuki, Ikemura, Masako, Makino, Yohsuke, Sawa, Rintaro, Iwase, Hirotaro, Ushiku, Tetsuo, Suzuki, Tadaki, Akitomi, Shinji

“…During the coronavirus disease 2019 (COVID‐19) pandemic, autopsies have provided valuable insights into the pathogenesis of COVID‐19. The precise effect of…”
Get full text

Effective infliximab therapy for the early regression of coronary artery aneurysm in Kawasaki disease by Nagatomo, Yusaku, Muneuchi, Jun, Nakashima, Yasutaka, Nanishi, Etsuro, Shirozu, Hiromitsu, Watanabe, Mamie, Uike, Kiyoshi, Nagata, Hazumu, Hirata, Yuichiro, Yamamura, Kenichiro, Takahashi, Yasuhiko, Okada, Seigo, Suzuki, Yasuo, Hasegawa, Shunji, Ohga, Shouichi

“…There is limited information available regarding the role of infliximab (IFX) following the acute phase of Kawasaki disease (KD). We aimed to evaluate whether…”
Get full text

High titers of infectious SARS-CoV-2 in corpses of patients with COVID-19 by Saitoh, Hisako, Sakai-Tagawa, Yuko, Nagasawa, Sayaka, Torimitsu, Suguru, Kubota, Kazumi, Hirata, Yuichiro, Iwatsuki-Horimoto, Kiyoko, Motomura, Ayumi, Ishii, Namiko, Okaba, Keisuke, Horioka, Kie, Abe, Hiroyuki, Ikemura, Masako, Rokutan, Hirofumi, Hinata, Munetoshi, Iwasaki, Akiko, Yasunaga, Yoichi, Nakajima, Makoto, Yamaguchi, Rutsuko, Tsuneya, Shigeki, Kira, Kei, Kobayashi, Susumu, Inokuchi, Go, Chiba, Fumiko, Hoshioka, Yumi, Mori, Aika, Yamamoto, Isao, Nakagawa, Kimiko, Katano, Harutaka, Iida, Shun, Suzuki, Tadaki, Akitomi, Shinji, Hasegawa, Iwao, Ushiku, Tetsuo, Yajima, Daisuke, Iwase, Hirotaro, Makino, Yohsuke, Kawaoka, Yoshihiro

“…•Infectious SARS-CoV-2 remained in 55% (6/11) corpses and 43% (13/30) specimens.•The highest infectious titer was 2.09E + 06 plaque-forming units/g in corpse…”
Get full text

COVID-19 Analysis in Tissue Samples Acquired by Minimally Invasive Autopsy in Out-of-Hospital Deaths with Postmortem Degeneration by Hirata, Yuichiro, Makino, Yohsuke, Iida, Shun, Katano, Harutaka, Nagasawa, Sayaka, Rokutan, Hirofumi, Hinata, Munetoshi, Iwasaki, Akiko, Yasunaga, Yoichi, Abe, Hiroyuki, Ikemura, Masako, Motomura, Ayumi, Kira, Kei, Kobayashi, Susumu, Tsuneya, Shigeki, Torimitsu, Suguru, Yamamoto, Isao, Nakagawa, Kimiko, Hasegawa, Iwao, Akitomi, Shinji, Yajima, Daisuke, Ushiku, Tetsuo, Saitoh, Hisako, Suzuki, Tadaki, Iwase, Hirotaro

“…Minimally invasive autopsy (MIA) is an alternative to a full autopsy for the collection of tissue samples from patients’ bodies using instruments such as a…”
Get full text

Effective shunt closure for pulmonary hypertension and liver dysfunction in congenital portosystemic venous shunt by Uike, Kiyoshi, Nagata, Hazumu, Hirata, Yuichiro, Yamamura, Kenichiro, Terashi, Eiko, Matsuura, Toshiharu, Morihana, Eiji, Ohkubo, Kazuhiro, Ishii, Kanako, Sakai, Yasunari, Taguchi, Tomoaki, Ohga, Shouichi

“…Objective Congenital portosystemic venous shunt (CPSVS) is a rare vascular malformation with a high risk of mortality from pulmonary arterial hypertension…”
Get full text

Diagnostic potential of stored dried blood spots for inborn errors of metabolism: a metabolic autopsy of medium-chain acyl-CoA dehydrogenase deficiency by Kaku, Noriyuki, Ihara, Kenji, Hirata, Yuichiro, Yamada, Kenji, Lee, Sooyoung, Kanemasa, Hikaru, Motomura, Yoshitomo, Baba, Haruhisa, Tanaka, Tamami, Sakai, Yasunari, Maehara, Yoshihiko, Ohga, Shouichi

“…It is estimated that 1-5% of sudden infant death syndrome (SIDS) cases might be caused by undiagnosed inborn errors of metabolism (IEMs); however, the…”
Get more information

SARS-CoV-2 Transmission from Virus-Infected Dead Hamsters by Iwatsuki-Horimoto, Kiyoko, Ueki, Hiroshi, Ito, Mutsumi, Nagasawa, Sayaka, Hirata, Yuichiro, Hashizume, Kenichiro, Ushiwata, Kazuho, Iwase, Hirotaro, Makino, Yohsuke, Ushiku, Tetsuo, Akitomi, Shinji, Imai, Masaki, Saitoh, Hisako, Kawaoka, Yoshihiro

“…Although it has been 2.5 years since the coronavirus disease 2019 (COVID-19) pandemic began, the transmissibility of severe acute respiratory syndrome…”
Get full text

Medical equipment deployment in pediatric emergency prehospital medical units in Japan by Kaku, Noriyuki, Nitta, Masahiko, Muguruma, Takashi, Hirata, Yuichiro, Tsukahara, Kohei, Knaup, Emily, Nosaka, Nobuyuki, Enomoto, Yuki

“…The deployment status of pediatric emergency equipment in ambulances in Japan is unknown. To investigate the status of and issues associated with prehospital…”
Get full text

Procalcitonin levels predicting the infliximab response of immunoglobulin resistant Kawasaki disease by Nakashima, Yasutaka, Nanishi, Etsuro, Yamamura, Kenichiro, Uike, Kiyoshi, Terashi, Eiko, Hirata, Yuichiro, Nagata, Hazumu, Morihana, Eiji, Tanaka, Tamami, Honjo, Satoshi, Takada, Hidetoshi, Ohga, Shouichi

“…•Serum procalcitonin concentrations predict resistance to infliximab treatment.•Procalcitonin concentrations were correlated with levels of inflammatory…”
Get full text

Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 neutralization by Miyamoto, Sho, Arashiro, Takeshi, Ueno, Akira, Kanno, Takayuki, Saito, Shinji, Katano, Harutaka, Iida, Shun, Ainai, Akira, Ozono, Seiya, Hemmi, Takuya, Hirata, Yuichiro, Moriyama, Saya, Kotaki, Ryutaro, Kinoshita, Hitomi, Yamada, Souichi, Shinkai, Masaharu, Fukushi, Shuetsu, Takahashi, Yoshimasa, Suzuki, Tadaki

“…The immune responses to SARS-CoV-2 variants in COVID-19 cases are influenced by various factors including pre-existing immunity via vaccination and prior…”
Get full text

Long Term Results and Predictors of Left Ventricular Function Recovery after Aortic Valve Replacement for Chronic Aortic Regurgitation by Saisho, Hiroyuki, Arinaga, Koichi, Kikusaki, Satoshi, Hirata, Yuichiro, Wada, Kumiko, Kakuma, Tatsuyuki, Tanaka, Hiroyuki

“…Objectives: In most patients with aortic regurgitation (AR), aortic valve replacement (AVR) improves left ventricular (LV) function, but some patients will not…”
Get full text