Search Results - "Hirata, Hiroaki"

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms by Dobrokhotov, Oleg, Samsonov, Mikhail, Sokabe, Masahiro, Hirata, Hiroaki

“…Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such…”
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Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner by Hirata, Hiroaki, Tatsumi, Hitoshi, Sokabe, Masahiro

“…We examined the effects of mechanical forces on actin polymerization at focal adhesions (FAs). Actin polymerization at FAs was assessed by introducing…”
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Prevalence and aggravation of cervical spine instabilities in rheumatoid arthritis during over 10 years: a prospective multicenter cohort study by Kanda, Yutaro, Yurube, Takashi, Hirata, Hiroaki, Sumi, Masatoshi

“…We designed a prospective multicenter cohort study to clarify a long-term, > 10-year prevalence and aggravation of cervical spine instabilities in rheumatoid…”
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Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions by Hirata, Hiroaki, Tatsumi, Hitoshi, Lim, Chwee Teck, Sokabe, Masahiro

“…Mechanical forces play a pivotal role in the regulation of focal adhesions (FAs) where the actin cytoskeleton is anchored to the extracellular matrix through…”
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Hip-sacroiliac joint-spine syndrome in total hip arthroplasty patients by Kaneuji, Ayumi, Fukui, Makoto, Takahashi, Eiji, Sanji, Yusuke, Hirata, Hiroaki, Kawahara, Norio

“…This study is designed to compare the extent of sacroiliac joint (SIJ) degeneration at total hip arthroplasty (THA) for two pathologies: osteoarthritis of the…”
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Epithelial bridges maintain tissue integrity during collective cell migration by Vedula, Sri Ram Krishna, Hirata, Hiroaki, Nai, Mui Hoon, Brugués, Agustı´, Toyama, Yusuke, Trepat, Xavier, Lim, Chwee Teck, Ladoux, Benoit

“…The ability of skin to act as a barrier is primarily determined by the efficiency of skin cells to maintain and restore its continuity and integrity. In fact,…”
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Tensile Loads on Tethered Actin Filaments Induce Accumulation of Cell Adhesion-Associated Proteins in Vitro by Kiyoshima, Daisuke, Tatsumi, Hitoshi, Hirata, Hiroaki, Sokabe, Masahiro

“…Focal adhesions (FAs) and adherens junctions (AJs), which serve as a mechanical interface of cell–matrix and cell–cell interactions, respectively, experience…”
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Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes by Hirata, Hiroaki, Samsonov, Mikhail, Sokabe, Masahiro

“…Confluence-dependent inhibition of epithelial cell proliferation, termed contact inhibition, is crucial for epithelial homeostasis and organ size control. Here…”
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Adaptive Parameter Tuning for Constructing Storage Tiers in an Autonomous Distributed Storage System by Nunome, Atsushi, Hirata, Hiroaki

“…We are developing an autonomous distributed storage system to make effective use of networked heterogeneous storage devices. It dynamically configures the…”
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Cell mechanosensing underlies homeostasis of multicellular systems by Nonomura, Keiko, Hirata, Hiroaki

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Molecular Mechanisms Underlying the Force-Dependent Regulation of Actin-to-ECM Linkage at the Focal Adhesions by Hirata, Hiroaki, Sokabe, Masahiro, Lim, Chwee Teck

“…The linkage of the actin cytoskeleton to extracellular matrices (ECMs) at focal adhesions provides a physical path for cells to exert traction forces on…”
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From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission by Katsuta, Hiroki, Sokabe, Masahiro, Hirata, Hiroaki

“…The contractile apparatus, stress fiber (SF), is connected to the cell adhesion machinery, focal adhesion (FA), at the termini of SF. The SF-FA complex is…”
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Mechanics of epithelial closure over non-adherent environments by Vedula, Sri Ram Krishna, Peyret, Grégoire, Cheddadi, Ibrahim, Chen, Tianchi, Brugués, Agustí, Hirata, Hiroaki, Lopez-Menendez, Horacio, Toyama, Yusuke, Neves de Almeida, Luís, Trepat, Xavier, Lim, Chwee Teck, Ladoux, Benoit

“…The closure of gaps within epithelia is crucial to maintain its integrity during biological processes such as wound healing and gastrulation. Depending on the…”
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Taurine Inhibits Glucocorticoid-Induced Bone Mitochondrial Injury, Preventing Osteonecrosis in Rabbits and Cultured Osteocytes by Hirata, Hiroaki, Ueda, Shusuke, Ichiseki, Toru, Shimasaki, Miyako, Ueda, Yoshimichi, Kaneuji, Ayumi, Kawahara, Norio

“…Mitochondrial injury has recently been implicated in the pathogenesis of glucocorticoid-induced osteonecrosis. Using cultured osteocytes and a rabbit model, we…”
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Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling by Ebata, Takahiro, Kawauchi, Keiko, Hirata, Hiroaki

“…Mechanical microenvironments, such as extracellular matrix stiffness and strain, have crucial roles in cancer progression. Cells sense their microenvironments…”
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Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines by Furuya, Kishio, Hirata, Hiroaki, Kobayashi, Takeshi, Sokabe, Masahiro

“…High interstitial level of ATP and its lysate adenosine in the cancer microenvironment are considered a halo mark of cancer. Adenosine acts as a strong immune…”
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Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance by Yurube, Takashi, Hirata, Hiroaki, Ito, Masaaki, Terashima, Yoshiki, Kakiuchi, Yuji, Kuroda, Ryosuke, Kakutani, Kenichiro

“…The intervertebral disc is the largest avascular low-nutrient organ in the body. Thus, resident cells may utilize autophagy, a stress-response survival…”
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Editorial: Multicellularity: Views from cellular signaling and mechanics by Hirata, Hiroaki, Nakazawa, Naotaka, Hirashima, Tsuyoshi, Ravasio, Andrea

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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments by Torii, Takeru, Sugimoto, Wataru, Itoh, Katsuhiko, Kinoshita, Natsuki, Gessho, Masaya, Goto, Toshiyuki, Uehara, Ikuno, Nakajima, Wataru, Budirahardja, Yemima, Miyoshi, Daisuke, Nishikata, Takahito, Tanaka, Nobuyuki, Hirata, Hiroaki, Kawauchi, Keiko

“…Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors; however,…”
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Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1 by Hirata, Hiroaki, Dobrokhotov, Oleg, Sokabe, Masahiro

“…Regulations of cell motility and proliferation are essential for epithelial development and homeostasis. However, it is not fully understood how these cellular…”
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