Sub-acute Demyelinating Polyradiculoneuropathy as an Initial Symptom of Peripheral T Cell Lymphoma, Not Otherwise Specified (PTCL-NOS)

Here we report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), who initially presented with peripheral neuropathy. Nerve conduction, cerebral spinal fluid studies and his clinical course were compatible with sub-acute demyelinating polyradiculoneuropathy. In additio...

Full description

Saved in:

Bibliographic Details
Published in:	Internal Medicine Vol. 51; no. 15; pp. 2015 - 2020
Main Authors:	Kawanishi, Kazunobu, Ohyama, Yasuyo, Kanai, Yoshitake, Hirase, Tikara, Tanaka, Hirokazu, Miyatake, Junichi, Tatsumi, Youichi, Ashida, Takashi, Nakamine, Hirokazu, Matsumura, Itaru
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Society of Internal Medicine 01-01-2012
Subjects:	Antineoplastic Combined Chemotherapy Protocols - administration & dosage CHOP chemotherapy Cyclophosphamide - administration & dosage demyelinating polyradiculoneuropathy Doxorubicin - administration & dosage Humans Lymph Nodes - immunology Lymph Nodes - pathology Lymphoma, T-Cell, Peripheral - complications Lymphoma, T-Cell, Peripheral - diagnosis Lymphoma, T-Cell, Peripheral - drug therapy Lymphoma, T-Cell, Peripheral - immunology Male Middle Aged not otherwise specified (PTCL-NOS) paraneoplastic peripheral neuropathy (PPN) peripheral T-cell lymphoma Polyradiculoneuropathy - drug therapy Polyradiculoneuropathy - etiology Polyradiculoneuropathy - immunology Positron-Emission Tomography Prednisolone - administration & dosage Sural Nerve - pathology Vincristine - administration & dosage
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Here we report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), who initially presented with peripheral neuropathy. Nerve conduction, cerebral spinal fluid studies and his clinical course were compatible with sub-acute demyelinating polyradiculoneuropathy. In addition, left cervical lymph node swelling was observed on admission. Diagnosis of PTCL-NOS was made by the histological, immunohistochemical, and Southern blot analyses on the biopsy specimen from the enlarged lymph node. Combination chemotherapy composed of cyclophosphamide, vincristine, doxorubicin and prednisolone (CHOP) was effective for polyneuropathy as well as for lymphoma. Several antibodies relating to paraneoplastic syndrome such as Ma1, Ma2, Amphiphysin, CV2, Ri, Yo and Hu were all negative. Because sural nerve biopsy performed prior to CHOP therapy revealed no infiltration of lymphoma cells, immune dysfunction mediated by some cytokine or unidentified autoantibody related to PTCL-NOS was thought to be involved in the polyradiculoneuropathy.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.51.7457