Search Results - "Hiraoka, Takehiro"

Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation by Fukui, Yamato, Hirota, Yasushi, Matsuo, Mitsunori, Gebril, Mona, Akaeda, Shun, Hiraoka, Takehiro, Osuga, Yutaka

“…Background Recurrent implantation failure is a critical issue in IVF‐ET treatment. Successful embryo implantation needs appropriate molecular and cellular…”
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CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model by Ono, Yosuke, Yoshino, Osamu, Hiraoka, Takehiro, Sato, Erina, Furue, Akiko, Nawaz, Allah, Hatta, Hideki, Fukushi, Yoshiyuki, Wada, Shinichiro, Tobe, Kazuyuki, Hirota, Yasushi, Osuga, Yutaka, Unno, Nobuya, Saito, Shigeru

“…In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type…”
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Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch by Kim, Jeonghyun, Ushida, Takashi, Montagne, Kevin, Hirota, Yasushi, Yoshino, Osamu, Hiraoka, Takehiro, Osuga, Yutaka, Furuakwa, Katsuko S.

“…The uterus plays an important and unique role during pregnancy and is a dynamic organ subjected to mechanical stimuli. It has been reported that infertility…”
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F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus by Egashira, Mahiro, Hirota, Yasushi, Shimizu-Hirota, Ryoko, Saito-Fujita, Tomoko, Haraguchi, Hirofumi, Matsumoto, Leona, Matsuo, Mitsunori, Hiraoka, Takehiro, Tanaka, Tomoki, Akaeda, Shun, Takehisa, Chiaki, Saito-Kanatani, Mayuko, Maeda, Kei-ichiro, Fujii, Tomoyuki, Osuga, Yutaka

“…Abstract Cellular senescence, defined as an irreversible cell cycle arrest, exacerbates the tissue microenvironment. Our previous study demonstrated that mouse…”
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Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females by Hiraoka, Takehiro, Hirota, Yasushi, Aikawa, Shizu, Iida, Rei, Ishizawa, Chihiro, Kaku, Tetsuaki, Hirata, Tomoyuki, Fukui, Yamato, Akaeda, Shun, Matsuo, Mitsunori, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Osuga, Yutaka

“…Adenomyosis is a benign uterine disease that causes dysmenorrhea, heavy menstrual bleeding, and infertility; however, its pathophysiology remains unclear…”
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Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation by Gebril, Mona, Hirota, Yasushi, Aikawa, Shizu, Fukui, Yamato, Kaku, Tetsuaki, Matsuo, Mitsunori, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Taha, Tamer, Balah, Osama Al, Elnoury, Mohamed Amr H, Fujii, Tomoyuki, Osuga, Yutaka

“…Progesterone receptor (PGR) is indispensable for pregnancy in mammals. Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after…”
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Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment by Fukui, Yamato, Hirota, Yasushi, Saito-Fujita, Tomoko, Aikawa, Shizu, Hiraoka, Takehiro, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Matsuo, Mitsunori, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Ikawa, Masahito, Osuga, Yutaka

“…Recent studies have demonstrated that the formation of an implantation chamber composed of a uterine crypt, an implantation-competent blastocyst, and uterine…”
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CD206+ M2-Like Macrophages Are Essential for Successful Implantation by Ono, Yosuke, Yoshino, Osamu, Hiraoka, Takehiro, Sato, Erina, Fukui, Yamato, Ushijima, Akemi, Nawaz, Allah, Hirota, Yasushi, Wada, Shinichiro, Tobe, Kazuyuki, Nakashima, Akitoshi, Osuga, Yutaka, Saito, Shigeru

“…Macrophages (MΦs) play important roles in implantation. Depletion of CD11b+ pan-MΦs in CD11b-diphtheria-toxin-receptor (DTR) mice is reported to cause…”
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Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment by Hiraoka, Takehiro, Hirota, Yasushi, Fukui, Yamato, Gebril, Mona, Kaku, Tetsuaki, Aikawa, Shizu, Hirata, Tomoyuki, Akaeda, Shun, Matsuo, Mitsunori, Haraguchi, Hirofumi, Saito-Kanatani, Mayuko, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Yoshino, Osamu, Fujii, Tomoyuki, Osuga, Yutaka

“…Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of…”
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DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice by Hiratsuka, Daiki, Aikawa, Shizu, Hirota, Yasushi, Fukui, Yamato, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Under ovarian hormone control, dormant blastocysts obtain implantation capacity (known as blastocyst activation) through their global gene expression. After…”
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Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion by Akaeda, Shun, Hirota, Yasushi, Fukui, Yamato, Aikawa, Shizu, Shimizu-Hirota, Ryoko, Kaku, Tetsuaki, Gebril, Mona, Hirata, Tomoyuki, Hiraoka, Takehiro, Matsuo, Mitsunori, Haraguchi, Hirofumi, Saito-Kanatani, Mayuko, Takeda, Norihiko, Fujii, Tomoyuki, Osuga, Yutaka

“…Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P 4 ) promotes CCA in the uterine…”
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Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor by Matsuo, Mitsunori, Hirota, Yasushi, Fukui, Yamato, Fujita, Hidetoshi, Saito-Fujita, Tomoko, Kaku, Tetsuaki, Gebril, Mona, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Tanaka, Tomoki, Haraguchi, Hirofumi, Saito-Kanatani, Mayuko, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Fujii, Tomoyuki, Osuga, Yutaka

“…Abstract Progestogens including progesterone (P4) and levonorgestrel (LNG) are clinically used for multiple purposes such as contraception and infertility…”
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The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion by Fukui, Yamato, Hirota, Yasushi, Aikawa, Shizu, Sakashita, Akihiko, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Ishizawa, Chihiro, Iida, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Hiraoka, Takehiro, Akaeda, Shun, Matsuo, Mitsunori, Osuga, Yutaka

“…Infertility occurs in 15% of couples worldwide. Recurrent implantation failure (RIF) is one of the major problems in in vitro fertilization and embryo transfer…”
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Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies by Elsherbini, Mohammed, Koga, Kaori, Hiraoka, Takehiro, Kumasawa, Keiichi, Maki, Eiko, Satake, Erina, Taguchi, Ayumi, Makabe, Tomoko, Takeuchi, Arisa, Izumi, Gentaro, Takamura, Masashi, Harada, Miyuki, Hirata, Tetsuya, Hirota, Yasushi, Wada-Hiraike, Osamu, Osuga, Yutaka

“…The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome…”
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A gene network of uterine luminal epithelium organizes mouse blastocyst implantation by Aikawa, Shizu, Hirota, Yasushi, Fukui, Yamato, Ishizawa, Chihiro, IIda, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day…”
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Uterine Receptivity is Reflected by LIF Expression in the Cervix by Fukui, Yamato, Hirota, Yasushi, Aikawa, Shizu, Ishizawa, Chihiro, Iida, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Recurrent implantation failure is a major problem in assisted reproductive technology (ART). Although ART systems have evolved rapidly over the decades, it is…”
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IL-33 Exacerbates Endometriotic Lesions via Polarizing Peritoneal Macrophages to M2 Subtype by Ono, Yosuke, Yoshino, Osamu, Hiraoka, Takehiro, Akiyama, Ikumi, Sato, Erina, Ito, Masami, Kobayashi, Mutsumi, Nakashima, Akitoshi, Wada, Shinichiro, Onda, Takashi, Unno, Nobuya, Osuga, Yutaka

“…In endometriosis, M2 macrophages (MΦ) are dominant and promote the development of endometriosis lesions. However, the factor(s) which induces M2 MΦ are…”
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MicroRNA-200a Locally Attenuates Progesterone Signaling in the Cervix, Preventing Embryo Implantation by Haraguchi, Hirofumi, Saito-Fujita, Tomoko, Hirota, Yasushi, Egashira, Mahiro, Matsumoto, Leona, Matsuo, Mitsunori, Hiraoka, Takehiro, Koga, Kaori, Yamauchi, Naoko, Fukayama, Masashi, Bartos, Amanda, Cha, Jeeyeon, Dey, Sudhansu K, Fujii, Tomoyuki, Osuga, Yutaka

“…Although cervical pregnancy and placenta previa, in which the embryo and placenta embed in or adjacent to the cervix, are life-threatening complications that…”
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Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study by Hiratsuka, Daiki, Omura, Erika, Ishizawa, Chihiro, Iida, Rei, Fukui, Yamato, Hiraoka, Takehiro, Akaeda, Shun, Matsuo, Mitsunori, Harada, Miyuki, Wada-Hiraike, Osamu, Osuga, Yutaka, Hirota, Yasushi

“…Abstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy…”
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Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis by Ono, Yosuke, Kawakita, Takako, Yoshino, Osamu, Sato, Erina, Kano, Kuniyuki, Ohba, Mai, Okuno, Toshiaki, Ito, Masami, Koga, Kaori, Honda, Masako, Furue, Akiko, Hiraoka, Takehiro, Wada, Shinichiro, Iwasa, Takeshi, Yokomizo, Takehiko, Aoki, Junken, Maeda, Nagamasa, Unno, Nobuya, Osuga, Yutaka, Hirata, Shuji

“…Sphingosine 1-phosphate (S1P), an inflammatory mediator, is abundantly contained in red blood cells and platelets. We hypothesized that the S1P concentration…”
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