Search Results - "Hirakawa, Akihiro"

An adaptive dose-finding approach for correlated bivariate binary and continuous outcomes in phase I oncology trials by Hirakawa, Akihiro

“…In this study, we developed a novel adaptive dose‐finding approach for inclusion of correlated bivariate binary and continuous outcomes in designing phase I…”
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Clinical impact of PCSK9 inhibitor on stabilization and regression of lipid-rich coronary plaques: a near-infrared spectroscopy study by Ota, Hideaki, Omori, Hiroyuki, Kawasaki, Masanori, Hirakawa, Akihiro, Matsuo, Hitoshi

“…Abstract Aims This study aimed to determine the effects of a proprotein convertase subtilisin-kexin type 9 inhibitor (PCSK9i) on coronary plaque volume and…”
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Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice by Komura, Shingo, Satake, Takashi, Goto, Atsushi, Aoki, Hitomi, Shibata, Hirofumi, Ito, Kenji, Hirakawa, Akihiro, Yamada, Yasuhiro, Akiyama, Haruhiko

“…Tendons are dense fibrous structures that attach muscles to bones. Healing of tendon injuries is a clinical challenge owing to poor regenerative potential and…”
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Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease by Takenaka, Kento, Kitazume, Yoshio, Kawamoto, Ami, Fujii, Toshimitsu, Udagawa, Yumi, Wanatabe, Ryosuke, Shimizu, Hiromichi, Hibiya, Shuji, Nagahori, Masakazu, Ohtsuka, Kazuo, Sato, Hiroyuki, Hirakawa, Akihiro, Watanabe, Mamoru, Okamoto, Ryuichi

“…Leucine-rich alpha-2 glycoprotein (LRG) is a newly studied biomarker for inflammatory diseases. This study aimed to investigate whether LRG can be used for…”
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Master protocol trials in oncology: Review and new trial designs by Hirakawa, Akihiro, Asano, Junichi, Sato, Hiroyuki, Teramukai, Satoshi

“…AbstractIn oncology, next generation sequencing and comprehensive genomic profiling have enabled the detailed classification of tumors using molecular biology…”
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Practical basket design for binary outcomes with control of family-wise error rate by Asano, Junichi, Sato, Hiroyuki, Hirakawa, Akihiro

“…A basket trial is a type of clinical trial in which eligibility is based on the presence of specific molecular characteristics across subpopulations with…”
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Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial by Nishikawa, Tadaaki, Hasegawa, Kosei, Matsumoto, Koji, Mori, Masahiko, Hirashima, Yasuyuki, Takehara, Kazuhiro, Ariyoshi, Kazuya, Kato, Tomoyasu, Yagishita, Shigehiro, Hamada, Akinobu, Kawasaki, Mamiko, Kawashima, Satoshi, Tomatsuri, Sawako, Nagasaka, Yukari, Yoshida, Hiroshi, Machida, Ryunosuke, Hirakawa, Akihiro, Nakamura, Kenichi, Yonemori, Kan

“…To investigate the efficacy and safety of trastuzumab deruxtecan, an antibody-drug conjugate targeting human epidermal growth factor receptor 2 (HER2) with a…”
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Diagnostic Accuracy of Artificial Intelligence-Based Angiography-Derived Fractional Flow Reserve Using Pressure Wire-Based Fractional Flow Reserve as a Reference by Omori, Hiroyuki, Kawase, Yoshiaki, Mizukami, Takuya, Tanigaki, Toru, Hirata, Tetsuo, Okubo, Munenori, Kamiya, Hiroki, Hirakawa, Akihiro, Kawasaki, Masanori, Kondo, Takeshi, Suzuki, Takahiko, Matsuo, Hitoshi

“…Background: Angiographic fractional flow reserve (angioFFR) is a novel artificial intelligence (AI)-based angiography-derived fractional flow reserve (FFR)…”
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A Bayesian basket trial design accounting for uncertainties of homogeneity and heterogeneity of treatment effect among subpopulations by Asano, Junichi, Hirakawa, Akihiro

“…Summary Basket trials are a recent and innovative approach in oncological clinical trial design. A basket trial is a type of clinical trial for which…”
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Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial by Ohsawa, Yutaka, Hagiwara, Hiroki, Nishimatsu, Shin-ichiro, Hirakawa, Akihiro, Kamimura, Naomi, Ohtsubo, Hideaki, Fukai, Yuta, Murakami, Tatsufumi, Koga, Yasutoshi, Goto, Yu-ichi, Ohta, Shigeo, Sunada, Yoshihide

“…ObjectiveThe aim of this study was to evaluate the efficacy and safety of high-dose taurine supplementation for prevention of stroke-like episodes of MELAS…”
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Phase 1 trial of zolbetuximab in Japanese patients with CLDN18.2+ gastric or gastroesophageal junction adenocarcinoma by Shitara, Kohei, Kawazoe, Akihito, Hirakawa, Akihiro, Nakanishi, Yuka, Furuki, Satomi, Fukuda, Musashi, Ueno, Yoko, Raizer, Jeffrey, Arozullah, Ahsan

“…Zolbetuximab is a chimeric monoclonal antibody that targets claudin‐18.2, a candidate biomarker in patients with advanced gastric/gastroesophageal cancer. This…”
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An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials by Sato, Hiroyuki, Hirakawa, Akihiro, Hamada, Chikuma

“…The paradigm of oncology drug development is expanding from developing cytotoxic agents to developing biological or molecularly targeted agents (MTAs)…”
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Exploring age-related changes in motor function: insights from the peak decline found in Koji Awareness screening test by Murofushi, Koji, Katagiri, Hiroki, Mitomo, Sho, Hirohata, Kenji, Furuya, Hidetaka, Hanazawa, Ryoichi, Hirakawa, Akihiro, Yagishita, Kazuyoshi, Kaneoka, Koji

“…The KOJI AWARENESS (KA) screening test assesses motor function in humans. We aimed to analyze the correlation between age and KA screening scores and to…”
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Large-scale mapping of positional changes of hypoxia-responsive genes upon activation by Nakayama, Koh, Shachar, Sigal, Finn, Elizabeth H, Sato, Hiroyuki, Hirakawa, Akihiro, Misteli, Tom

“…Chromosome structure and nuclear organization are important factors in the regulation of gene expression. Transcription of a gene is influenced by local and…”
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Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis by Yamada, Shinichiro, Hashizume, Atsushi, Hijikata, Yasuhiro, Ito, Daisuke, Kishimoto, Yoshiyuki, Iida, Madoka, Koike, Haruki, Hirakawa, Akihiro, Katsuno, Masahisa

“…ObjectiveWe aimed to investigate the validity of urinary N-terminal titin fragment as a biomarker for amyotrophic lateral sclerosis (ALS).MethodsWe…”
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Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA) by Matsumoto, Toshio, Yamamoto, Kazuhiko, Takeuchi, Tsutomu, Tanaka, Yoshiya, Tanaka, Sakae, Nakano, Tetsuo, Ito, Masako, Tomomitsu, Tatsushi, Hirakawa, Akihiro, Soen, Satoshi

“…Introduction Eldecalcitol increases bone mineral density (BMD) and reduces vertebral fracture in patients with primary osteoporosis. However, the effect of…”
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First-line treatment for lung cancer among Japanese older patients: A real-world analysis of hospital-based cancer registry data by Noda-Narita, Shoko, Kawachi, Asuka, Okuyama, Ayako, Sadachi, Ryo, Hirakawa, Akihiro, Goto, Yasushi, Fujiwara, Yasuhiro, Higashi, Takahiro, Yonemori, Kan

“…Aging of the population has led to an increase in the prevalence of cancer among older adults. In Japan, single agent chemotherapy was recommended for advanced…”
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Paclitaxel-induced peripheral neuropathy in patients receiving adjuvant chemotherapy for breast cancer by Tanabe, Yuko, Hashimoto, Kenji, Shimizu, Chikako, Hirakawa, Akihiro, Harano, Kenichi, Yunokawa, Mayu, Yonemori, Kan, Katsumata, Noriyuki, Tamura, Kenji, Ando, Masashi, Kinoshita, Takayuki, Fujiwara, Yasuhiro

“…Background The long-term outcomes and risk factors of paclitaxel-induced peripheral neuropathy (PIPN) have not yet been fully elucidated. Methods We identified…”
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Risk factors of local recurrence after surgery in extraabdominal desmoid‐type fibromatosis: A multicenter study in Japan by Nishida, Yoshihiro, Hamada, Shunsuke, Kawai, Akira, Kunisada, Toshiyuki, Ogose, Akira, Matsumoto, Yoshihiro, Ae, Keisuke, Toguchida, Junya, Ozaki, Toshifumi, Hirakawa, Akihiro, Motoi, Toru, Sakai, Tomohisa, Kobayashi, Eisuke, Gokita, Tabu, Okamoto, Takeshi, Matsunobu, Tomoya, Shimizu, Koki, Koike, Hiroshi

“…This study was undertaken to clarify the risk factors, including the mutation status of CTNNB1, for the local recurrence after surgery of the rare disease…”
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Subjects at risk of Parkinson’s disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study by Hattori, Makoto, Tsuboi, Takashi, Yokoi, Katsunori, Tanaka, Yasuhiro, Sato, Maki, Suzuki, Keisuke, Arahata, Yutaka, Hori, Akihiro, Kawashima, Motoshi, Hirakawa, Akihiro, Washimi, Yukihiko, Watanabe, Hirohisa, Katsuno, Masahisa

“…Introduction The present study aimed to survey the prevalence of prodromal symptoms of Parkinson’s disease (PD) in Japanese health checkup examinees, for…”
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