Search Results - "Hiraiwa, Manami"
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How does spaceflight affect the acquired immune system?
Published in NPJ microgravity (07-05-2020)“…The impact of spaceflight on the immune system has been investigated extensively during spaceflight missions and in model experiments conducted on Earth. Data…”
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2
The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis
Published in Development (Cambridge) (15-07-2018)“…Erk5 belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by Mek5, Erk5 modulates several signaling pathways in a…”
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3
Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice
Published in Journal of cellular physiology (01-11-2022)“…Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L‐type amino acid transporter 1 (LAT1), encoded…”
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4
MAPK Erk5 in Leptin Receptor‒Expressing Neurons Controls Body Weight and Systemic Energy Homeostasis in Female Mice
Published in Endocrinology (Philadelphia) (01-12-2019)“…Extracellular signal-regulated kinase 5 (Erk5), a member of the MAPK family, is specifically phosphorylated and activated by MAPK/Erk kinase-5. Although it has…”
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The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis
Published in Spine Surgery and Related Research (27-07-2022)“…Introduction: Amino acid transporters are transmembrane proteins that are known to mediate the transfer of amino acids. As one of the amino acid transporters,…”
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mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis
Published in Frontiers in pharmacology (13-06-2019)“…The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and…”
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7
SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability
Published in Communications biology (11-01-2022)“…Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most malignant form of glioma. The implication and underlying mechanisms of SMAD…”
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Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis
Published in Stem cell reports (10-07-2018)“…The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in…”
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Daily intake of polyamine-rich Saccharomyces cerevisiae S631 prevents osteoclastic activation and bone loss in ovariectomized mice
Published in Food science and biotechnology (01-08-2019)“…An imbalance in the sophisticated regulation between bone-resorbing osteoclasts and bone-forming osteoblasts leads to the pathogenesis and etiology of certain…”
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CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway
Published in Oncogene (15-04-2021)“…Glioblastoma (GBM) is the most malignant form of glioma. Glioma stem cells (GSCs) contribute to the initiation, progression, and recurrence of GBM as a result…”
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11
Cartilage Induction from Mouse Mesenchymal Stem Cells in High-density Micromass Culture
Published in Bio-protocol (05-01-2019)“…Mesenchymal stem cells have the ability to differentiate into multiple lineages, including adipocytes, osteoblasts and chondrocytes. Mesenchymal stem cells can…”
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Characteristics of Scoliosis in Mice Induced by Chondrocyte-specific Inactivation of L-type Amino Acid Transporter 1
Published in Spine (Philadelphia, Pa. 1976) (15-02-2024)“…A mouse study of the Slc7a5 gene using conditional knockout to assess the effects of its inactivation on spinal deformity. This study aimed to investigate…”
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Cover Image, Volume 237, Number 11, November 2022
Published in Journal of cellular physiology (01-11-2022)“…Front Cover: The cover image is based on the Research Article Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models…”
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14
Hypoxia affects Slc7a5 expression through HIF‐2α in differentiated neuronal cells
Published in FEBS open bio (01-02-2019)“…An imbalance of branched‐chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L‐type amino…”
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15
How does spaceflight affect the acquired immune system?
Published in NPJ microgravity (07-05-2020)“…The impact of spaceflight on the immune system has been investigated extensively during spaceflight missions and in model experiments conducted on Earth. Data…”
Get full text
Journal Article -
16
Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α
Published in Pharmacology (2018)“…The availability of amino acid in the brown adipose tissue (BAT) has been shown to be altered under various conditions; however, little is known about the…”
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17
The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis
Published in Spine Surgery and Related Research (2021)“…Introduction. Amino acid transporters are transmembrane proteins that are known to mediate the transfer of amino acids. As one of the amino acid transporters,…”
Get full text
Journal Article