Search Results - "Hirai, Yohei"

A crucial stem cell plasticity regulation pathway: identification of key elements using the NCCIT human embryonic carcinoma cell line by Nozaki, Sae, Hirai, Yohei

“…Abstract Upon removal of stemness factors, a small subpopulation of embryonic stem cells (ESCs) spontaneously extrudes the t-SNARE protein syntaxin-4, which…”
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Cooperation of membrane-translocated syntaxin4 and basement membrane for dynamic mammary epithelial morphogenesis by Hirose, Yuina, Hirai, Yohei

“…Mammary epithelia undergo dramatic morphogenesis after puberty. During pregnancy, luminal epithelial cells in ductal trees are arranged to form well-polarized…”
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PRSS3/mesotrypsin as a putative regulator of the biophysical characteristics of epidermal keratinocytes in superficial layers by Kida, Moeko, Abe, Junya, Hori, Haruna, Hirai, Yohei

“…Mesotrypsin, encoded by the PRSS3 gene, is a distinctive trypsin isoform renowned for its exceptional resistance to traditional trypsin inhibitors and unique…”
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Extracellular epimorphin impairs expression and processing of profilaggrin in HaCaT keratinocytes by Hori, Haruna, Kotani, Ayaka, Abe, Junya, Matsuguchi, Shuji, Hirai, Yohei

“…The expression and processing of filaggrin, a filament-associated protein in the skin epidermis, is closely associated with keratinocyte cornification. The…”
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Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line by Aono, Shinya, Hirai, Yohei

“…Extensive studies have identified a large number of the molecular components of cellular tight junctions (TJ), including the claudins, occludin and ZO-1/2, and…”
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Membrane‐tethered syntaxin‐4 locally abrogates E‐cadherin function and activates Smad signals, contributing to asymmetric mammary epithelial morphogenesis by Hirose, Yuina, Shirai, Kota, Hirai, Yohei

“…Spatial and temporal epithelial‐mesenchymal transition (EMT) is a critical event for the generation of asymmetric epithelial architectures. We found that only…”
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Restoration of calcium-induced differentiation potential and tight junction formation in HaCaT keratinocytes by functional attenuation of overexpressed high mobility group box-1 protein by Tanaka, Fumika, Uda, Minori, Hirose, Yuina, Hirai, Yohei

“…HaCaT cells have been widely used as undifferentiated epidermal keratinocytes, since these non-tumorigenic cells can be readily maintained in conventional…”
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Increased expression of epimorphin in a peritoneal fibrosis mouse model by Yamada, Muneharu, Hirai, Yohei, Inoue, Dan, Komatsu, Shuhei, Uchida, Takahiro, Kojima, Tadasu, Tomiyasu, Tomohiro, Yoshikawa, Noriko, Oda, Takashi

“…Background: Long-term peritoneal dialysis results in functional and histopathological alterations of the peritoneal membrane, leading to peritoneal fibrosis…”
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Single proteins might have dual but related functions in intracellular and extracellular microenvironments by Radisky, Derek C, Stallings-Mann, Melody, Hirai, Yohei, Bissell, Mina J

“…Maintenance of organ homeostasis and control of appropriate responses to environmental alterations requires the coordination of cellular functions and tissue…”
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Suppression of P-cadherin expression as a key regulatory element for embryonic stem cell stemness by Takeda, Yuka, Matsuguchi, Shuji, Nozaki, Sae, Mihara, Taisei, Abe, Junya, Hirai, Yohei

“…In embryonic stem (ES) cell colonies, a small subpopulation that changes cell shape and loses pluripotency often appears in two-dimensional (2D) cultures, even…”
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Generation of iPS-derived model cells for analyses of hair shaft differentiation by Kido, Takumi, Horigome, Tomoatsu, Uda, Minori, Adachi, Naoki, Hirai, Yohei

“…Biological evaluation of hair growth/differentiation activity in vitro has been a formidable challenge, primarily due to the lack of relevant model cell…”
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A newly established culture method highlights regulatory roles of retinoic acid on morphogenesis and calcification of mammalian limb cartilage by Masuda, Eizo, Shirai, Kota, Maekubo, Kenji, Hirai, Yohei

“…During mammalian embryogenesis, sclerotome-derived chondrocytes in the limb bud are arranged into a complicated bone shape with specific areas undergoing…”
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Krtap11-1, a hair keratin-associated protein, as a possible crucial element for the physical properties of hair shafts by Fujimoto, Shunsuke, Takase, Takahisa, Kadono, Nanako, Maekubo, Kenji, Hirai, Yohei

“…Abstract Background The physical properties of the hair are predominantly determined by the assembly of keratin bundles. The keratin-associated proteins…”
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Extracellularly Extruded Syntaxin‐4 Binds to Laminin and Syndecan‐1 to Regulate Mammary Epithelial Morphogenesis by Shirai, Kota, Hagiwara, Natsumi, Horigome, Tomoatsu, Hirose, Yuina, Kadono, Nanako, Hirai, Yohei

“…ABSTRACT Epithelial morphogenesis in the mammary gland proceeds as a consequence of complex cell behaviors including apoptotic cell death and…”
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Corticotropin‐releasing hormone‐binding protein is up‐regulated by brain‐derived neurotrophic factor and is secreted in an activity‐dependent manner in rat cerebral cortical neurons by Adachi, Naoki, Suzuki, Shingo, Matsuoka, Hidetada, Fushimi, Satoko, Ono, Junichiro, Ohta, Ken‐ichi, Hirai, Yohei, Miki, Takanori, Koshimizu, Hisatsugu

“…A recent study revealed that corticotropin‐releasing hormone (CRH) in the cerebral cortex (CTX) plays a regulatory role in emotional behaviors in rodents…”
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Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte by Takase, Takahisa, Hirai, Yohei

“…Abstract Background AHF/trichohyalin is a large structural protein abundant in the inner root sheath (IRS) of anagenic hair follicles, which has been thought…”
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Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway by Numakawa, Tadahiro, Odaka, Haruki, Adachi, Naoki, Chiba, Shuichi, Ooshima, Yoshiko, Matsuno, Hitomi, Nakajima, Shingo, Yoshimura, Aya, Fumimoto, Kazuhiro, Hirai, Yohei, Kunugi, Hiroshi

“…Prolonged and intense stress chronically increases blood concentration of glucocorticoids, which in turn causes downregulation of glucocorticoid receptor (GR)…”
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CCAAT/enhancer binding protein beta (C/EBPβ) isoform balance as a regulator of epithelial-mesenchymal transition in mouse mammary epithelial cells by Miura, Yuka, Hagiwara, Natsumi, Radisky, Derek C., Hirai, Yohei

“…Activation of the epithelial-mesenchymal transition (EMT) program promotes cell invasion and metastasis, and is reversed through mesenchymal-epithelial…”
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Extracellularly Extruded Syntaxin-4 Is a Potent Cornification Regulator of Epidermal Keratinocytes by Kadono, Nanako, Hagiwara, Natsumi, Tagawa, Takashi, Maekubo, Kenji, Hirai, Yohei

“…In the skin epidermis, keratinocytes undergo anchorage-dependent cornification, which gives rise to stratified multilayers, each with a distinct…”
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Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor by Okugawa, Yoji, Hirai, Yohei

“…Abstract Background The epidermal stratification/differentiation program is initiated in keratinocytes by a basement membrane-detachment cue and subsequently…”
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