Search Results - "Hiršl, Lea"

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells by Rožmanić, Carmen, Lisnić, Berislav, Pribanić Matešić, Marina, Mihalić, Andrea, Hiršl, Lea, Park, Eugene, Lesac Brizić, Ana, Indenbirken, Daniela, Viduka, Ina, Šantić, Marina, Adler, Barbara, Yokoyama, Wayne M., Krmpotić, Astrid, Juranić Lisnić, Vanda, Jonjić, Stipan, Brizić, Ilija

“…Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the…”
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Immune responses to congenital cytomegalovirus infection by Brizić, Ilija, Hiršl, Lea, Britt, William J., Krmpotić, Astrid, Jonjić, Stipan

“…Human cytomegalovirus (HCMV) is the most common cause of viral infection acquired in utero. Even though the infection has been studied for several decades,…”
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Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus by Ravlić, Sanda, Brgles, Marija, Hiršl, Lea, Jonjić, Stipan, Halassy, Beata

“…There is a large unmet need for a prophylactic vaccine against human cytomegalovirus (HCMV) to combat the ubiquitous infection that is ongoing with this…”
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CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice by Brizić, Ilija, Hiršl, Lea, Šustić, Marko, Golemac, Mijo, Britt, William J., Krmpotić, Astrid, Jonjić, Stipan

“…Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental…”
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Memory CD8 T Cells Generated by Cytomegalovirus Vaccine Vector Expressing NKG2D Ligand Have Effector-Like Phenotype and Distinct Functional Features by Šustić, Marko, Cokarić Brdovčak, Maja, Lisnić, Berislav, Materljan, Jelena, Juranić Lisnić, Vanda, Rožmanić, Carmen, Indenbirken, Daniela, Hiršl, Lea, Busch, Dirk H., Brizić, Ilija, Krmpotić, Astrid, Jonjić, Stipan

“…Viral vectors have emerged as a promising alternative to classical vaccines due to their great potential for induction of a potent cellular and humoral…”
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Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines by Hiršl, Lea, Brizić, Ilija, Jenuš, Tina, Juranić Lisnić, Vanda, Reichel, Johanna Julia, Jurković, Slaven, Krmpotić, Astrid, Jonjić, Stipan

“…The development of a vaccine against human cytomegalovirus (CMV) has been a subject of long-term medical interest. The research during recent years identified…”
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Non-phosphorylated Tyr-1248 form of human epidermal growth factor receptor 2 (HER2) predicts resistance to trastuzumab therapy and poor disease-free survival of HER2-positive breast cancer patients by Ramić, Snježana, Paić, Frane, Smajlbegović, Velda, Perić Balja, Melita, Hiršl, Lea, Marton, Ingrid, Knežević, Fabijan

“…To determine the predictive value of phosphorylated human epidermal growth factor receptor 2 (pHER2Y1248) status in breast cancer (BC) patients undergoing…”
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An IFNγ-dependent immune–endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response by Šestan, Marko, Mikašinović, Sanja, Benić, Ante, Wueest, Stephan, Dimitropoulos, Christoforos, Mladenić, Karlo, Krapić, Mia, Hiršl, Lea, Glantzspiegel, Yossef, Rasteiro, Ana, Aliseychik, Maria, Cekinović Grbeša, Đurđica, Turk Wensveen, Tamara, Babić, Marina, Gat-Viks, Irit, Veiga-Fernandes, Henrique, Konrad, Daniel, Wensveen, Felix M., Polić, Bojan

“…Viral infection makes us feel sick as the immune system alters systemic metabolism to better fight the pathogen. The extent of these changes is relative to the…”
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254 NTX-1088, a potent anti-PVR Mab induces DNAM1-mediated antitumor immunity by Atieh, Anas, Obiedat, Akram, Cinamon, Guy, Rovis, Tihana Lenac, Brlic, Paola Kucan, Hirsl, Lea, Mandelboim, Ofer, Jonjic, Stipan, Paz, Keren, Tsukerman, Pini

“…BackgroundPoliovirus receptor (PVR, CD155) represents a resistance mechanism to approved immune checkpoint inhibitors (ICIs). It is a key regulator of immune…”
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Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation by Brizić, Ilija, Šušak, Božo, Arapović, Maja, Huszthy, Peter C., Hiršl, Lea, Kveštak, Daria, Juranić Lisnić, Vanda, Golemac, Mijo, Pernjak Pugel, Ester, Tomac, Jelena, Oxenius, Annette, Britt, William J., Arapović, Jurica, Krmpotić, Astrid, Jonjić, Stipan

“…Congenital HCMV infection is a leading infectious cause of long‐term neurodevelopmental sequelae. Infection of newborn mice with mouse cytomegalovirus (MCMV)…”
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CD4 T cells are required for maintenance of CD8 T RM cells and virus control in the brain of MCMV-infected newborn mice by Brizić, Ilija, Hiršl, Lea, Šustić, Marko, Golemac, Mijo, Britt, William J, Krmpotić, Astrid, Jonjić, Stipan

“…Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental…”
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Non-phosphorylated Tyr-1248 form of human epidermal growth factor receptor 2 by Ramie, Snjezana, Balja, Melita Perie, Marton, Ingrid, Knezevie, Fabijan, Smajlbegovie, Velda, Paic, Frane, Hirsl, Lea

“…Aim To determine the predictive value of phosphorylated human epidermal growth factor receptor 2 ([pHER2.sup.Y1248]) status in breast cancer (BC) patients…”
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Abstract P102: NTX-1088, A potent first-in-class, anti-PVR mAb, restores expression and function of DNAM1 for optimal DNAM1-mediated antitumor immunity by Tsukerman, Pini, Atieh, Anas, Obeidat, Akram, Paz, Keren, Cinamon, Guy, Roviš, Tihana Lenac, Hirsl, Lea, Brilc, Paola Kucan, Jonjic, Stipan, Mandelboim, Ofer

“…Abstract The poliovirus receptor (PVR, CD155) represents a resistance mechanism to approved immune checkpoint inhibitors (ICIs). It is a key regulator of…”
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474 First-in-class anti-PVR mAb NTX1088 restores expression of DNAM1 and augments antitumor immunity by Obeidat, Akram, Atieh, Anas, Vitenshtein, Alon, Cinamon, Guy, Paz, Keren, Roviš, Tihana, Brilc, Paola, Hirsl, Lea, Mandelboim, Ofer, Jonjic, Stipan, Pini Tsukerman

“…BackgroundPoliovirus receptor (PVR, CD155) is a novel oncology target, differentially overexpressed in a wide range of solid tumors, which recently emerged as…”
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Abstract 5534: NTX-1088, a first-in-class anti-PVR mAb mediates DNAM1-dependent antitumor immunity by Obiedat, Akram, Atieh, Anas, Cinamon, Guy, Paz, Keren, Brilc, Paola Kucan, Hirsl, Lea, Roviš, Tihana Lenac, Mandelboim, Ofer, Jonjic, Stipan, Tsukerman, Pini

“…Abstract Poliovirus receptor (PVR, CD155), expressed on the surface of cancer cells, represents a resistance mechanism to approved immune checkpoint inhibitors…”
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