Search Results - "Hipp, S"

Cancer statistics for adolescents and young adults, 2020 by Miller, Kimberly D., Fidler‐Benaoudia, Miranda, Keegan, Theresa H., Hipp, Heather S., Jemal, Ahmedin, Siegel, Rebecca L.

“…Cancer statistics for adolescents and young adults (AYAs) (aged 15‐39 years) are often presented in aggregate, masking important heterogeneity. The authors…”
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Molecular chaperone functions in protein folding and proteostasis by Kim, Yujin E, Hipp, Mark S, Bracher, Andreas, Hayer-Hartl, Manajit, Hartl, F Ulrich

“…The biological functions of proteins are governed by their three-dimensional fold. Protein folding, maintenance of proteome integrity, and protein homeostasis…”
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Proteostasis impairment in protein-misfolding and -aggregation diseases by Hipp, Mark S, Park, Sae-Hun, Hartl, F. Ulrich

“…Highlights • Cells possess a complex proteostasis network (PN) to ensure protein homeostasis. • Aggregates permanently engage molecular chaperones and other PN…”
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PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone by Park, Sae-Hun, Kukushkin, Yury, Gupta, Rajat, Chen, Taotao, Konagai, Ayano, Hipp, Mark S., Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Dysfunction of protein quality control contributes to the cellular pathology of polyglutamine (polyQ) expansion diseases and other neurodegenerative disorders…”
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The nucleolus functions as a phase-separated protein quality control compartment by Frottin, F, Schueder, F, Tiwary, S, Gupta, R, Körner, R, Schlichthaerle, T, Cox, J, Jungmann, R, Hartl, F U, Hipp, M S

“…The nuclear proteome is rich in stress-sensitive proteins, which suggests that effective protein quality control mechanisms are in place to ensure…”
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In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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The endoplasmic reticulum: A hub of protein quality control in health and disease by Vincenz-Donnelly, Lisa, Hipp, Mark S.

“…One third of the eukaryotic proteome is synthesized at the endoplasmic reticulum (ER), whose unique properties provide a folding environment substantially…”
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In Situ Architecture and Cellular Interactions of PolyQ Inclusions by Bäuerlein, Felix J.B., Saha, Itika, Mishra, Archana, Kalemanov, Maria, Martínez-Sánchez, Antonio, Klein, Rüdiger, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain…”
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A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo by Hipp, S, Tai, Y-T, Blanset, D, Deegen, P, Wahl, J, Thomas, O, Rattel, B, Adam, P J, Anderson, K C, Friedrich, M

“…B-cell maturation antigen (BCMA) is a highly plasma cell-selective protein that is expressed on malignant plasma cells of multiple myeloma (MM) patients and…”
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In situ architecture of neuronal α-Synuclein inclusions by Trinkaus, Victoria A., Riera-Tur, Irene, Martínez-Sánchez, Antonio, Bäuerlein, Felix J. B., Guo, Qiang, Arzberger, Thomas, Baumeister, Wolfgang, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Fernández-Busnadiego, Rubén

“…The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long…”
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Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model by Yuste-Checa, Patricia, Trinkaus, Victoria A., Riera-Tur, Irene, Imamoglu, Rahmi, Schaller, Theresa F., Wang, Huping, Dudanova, Irina, Hipp, Mark S., Bracher, Andreas, Hartl, F. Ulrich

“…Spreading of aggregate pathology across brain regions acts as a driver of disease progression in Tau-related neurodegeneration, including Alzheimer’s disease…”
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Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States by Kawwass, Jennifer F., M.D, Kulkarni, Aniket K., M.B.B.S., M.P.H, Hipp, Heather S., M.D, Crawford, Sara, Ph.D, Kissin, Dmitry M., M.D., M.P.H, Jamieson, Denise J., M.D., M.P.H

“…Objective To investigate the associations among underweight body mass index (BMI), pregnancy, and obstetric outcomes among women using assisted reproductive…”
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Fertility Considerations in Transgender Persons by Neblett, Michael F., MD, Hipp, Heather S., MD

“…Hormonal therapy and gender-affirming surgeries in transgender people have known deleterious impacts on future fertility using one's own gametes. This review…”
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Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function by Hosp, Fabian, Gutiérrez-Ángel, Sara, Schaefer, Martin H., Cox, Jürgen, Meissner, Felix, Hipp, Mark S., Hartl, F.-Ulrich, Klein, Rüdiger, Dudanova, Irina, Mann, Matthias

“…Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The…”
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Sis1 potentiates the stress response to protein aggregation and elevated temperature by Klaips, Courtney L., Gropp, Michael H. M., Hipp, Mark S., Hartl, F. Ulrich

“…Cells adapt to conditions that compromise protein conformational stability by activating various stress response pathways, but the mechanisms used in sensing…”
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Molecular and structural architecture of polyQ aggregates in yeast by Gruber, Anselm, Hornburg, Daniel, Antonin, Matthias, Krahmer, Natalie, Collado, Javier, Schaffer, Miroslava, Zubaite, Greta, Lüchtenborg, Christian, Sachsenheimer, Timo, Brügger, Britta, Mann, Matthias, Baumeister, Wolfgang, Hartl, F. Ulrich, Hipp, Mark S., Fernández-Busnadiego, Rubén

“…Huntington’s disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms…”
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Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation by Trentini, Débora Broch, Pecoraro, Matteo, Tiwary, Shivani, Cox, Jürgen, Mann, Matthias, Hipp, Mark S., Hartl, F. Ulrich

“…Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes…”
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system by Saha, Itika, Yuste-Checa, Patricia, Da Silva Padilha, Miguel, Guo, Qiang, Körner, Roman, Holthusen, Hauke, Trinkaus, Victoria A., Dudanova, Irina, Fernández-Busnadiego, Rubén, Baumeister, Wolfgang, Sanders, David W., Gautam, Saurabh, Diamond, Marc I., Hartl, F. Ulrich, Hipp, Mark S.

“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease by Hipp, Mark S, Patel, Chetan N, Bersuker, Kirill, Riley, Brigit E, Kaiser, Stephen E, Shaler, Thomas A, Brandeis, Michael, Kopito, Ron R

“…Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated…”
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