Search Results - "Hiorns, L R"

Variation in RNA expression and genomic DNA content acquired during cell culture by HIORNS, L. R, BRADSHAW, T. D, SKELTON, L. A, YU, Q, KELLAND, L. R, LEYLAND-JONES, B

“…Specific chromosomal abnormalities are increasingly recognised to be associated with particular tumour subtypes. These cytogenetic abnormalities define the…”
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Interstitial insertion of retinoic acid receptor-α gene in acute promyelocytic leukemia with normal chromosomes 15 and 17 by HIORNS, L. R, MIN, T, SWANSBURY, G. J, ZELENT, A, DYER, M. J. S, CATOVSKY, D

“…The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic…”
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Additional chromosome abnormalities confer worse prognosis in acute promyelocytic leukaemia by HIORNS, LYNNE R., SWANSBURY, G. JOHN, MEHTA, JAYESH, MIN, TOON, DAINTON, MELISSA G., TRELEAVEN, JENNIE, POWLES, RAYMOND L., CATOVSKY, DANIEL

“…Acute promyelocytic leukaemia (APL) has been associated with a favourable prognosis in many studies of acute myeloid leukaemia. A series of 54 patients treated…”
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Genomic Imbalances Associated with Acquired Resistance to Platinum Analogues by Leyland-Jones, Brian, Kelland, Lloyd R., Harrap, Kenneth R., Hiorns, Lynne R.

“…During the past several years, a panel of human tumor cell lines (predominantly ovarian) with acquired resistance to cisplatin, the orally bioavailable…”
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Expression of c-myc oncoprotein in chronic T cell leukemias by Maljaie, S H, Brito-Babapulle, V, Matutes, E, Hiorns, L R, De Schouwer, P J, Catovsky, D

“…T cell clones in patients with ataxia telangiectasia (AT) and T cell prolymphocytic leukemia (T-PLL) have identical chromosome abnormalities, namely…”
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Heterogeneity of breakpoints at the transcriptional co-activator gene, BOB-1, in lymphoproliferative disease by Yuille, M A, Galiegue-Zouitina, S, Hiorns, L R, Jadayel, D, De Schouwer, P J, Catovsky, D, Dyer, M J, Kerckaert, J P

“…Chromosome 11q23 is frequently a site of chromosomal translocation in both acute leukemias and chronic lymphoproliferative disorders. In the former, an 8 kb…”
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A molecular cytogenetic approach to studying platinum resistance by Hiorns, L.R, Seckl, M.J, Paradinas, F, Sharp, S.Y, Skelton, L.A, Brunstrom, G, Newlands, E.S, Kelland, L.R, Leyland-Jones, B

“…The technique of comparative genomic hybridisation (CGH) has until recently been used to screen for common genomic abnormalities in fresh tumour material; it…”
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Peripheral blood involvement in non-Hodgkin's lymphoma detected by clonal gene rearrangement as a biological prognostic marker by HIORNS, L. R, NICHOLLS, J, SLOANE, J. P, HORWICH, A, ASHLEY, S, BRADA, M

“…Peripheral blood from 67 patients with non-Hodgkin's lymphoma was examined at initial diagnosis for the presence of circulating lymphoma cells by DNA…”
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Chromosomal Assignments of the Genes Coding for Human Types II, III, and IV Collagen: A Dispersed Gene Family by Solomon, E., Hiorns, L. R., Spurr, N., Kurkinen, M., Barlow, D., Hogan, B. L. M., Dalgleish, R.

“…The human type II collagen gene, COL2A1, has been assigned to chromosome 12, the type III gene, COL3A1, to chromosome 2, and one of the type IV genes, COL4A1,…”
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Interleukin-4 Enhances the Survival of Severe Combined Immunodeficient Mice Engrafted With Human B-Cell Precursor Leukemia by Mitchell, Paul L.R., Clutterbuck, Robyn D., Powles, Ray L., De Lord, Corinne, Morilla, Ricardo, Hiorns, Lynne R., Titley, Jennifer, Catovsky, Daniel, Millar, John L.

“…Human interleukin-4 (hulL-4) has been shown to inhibit the growth in vitro of cells from patients with acute lymphoblastic leukemia (ALL). With the aim of…”
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Genetic Analysis of the 15;17 Chromosome Translocation Associated with Acute Promyelocytic Leukemia by Sheer, Denise, Hiorns, Lynne R., Stanley, Karina F., Goodfellow, Peter N., Swallow, Dallas M., Povey, Susan, Heisterkamp, Nora, Groffen, John, Stephenson, John R., Solomon, Ellen

“…Somatic cell hybrids have been constructed between a thymidine kinase-deficient mouse cell line and blood leukocytes from a patient with acute promyelocytic…”
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RFLP for the human erb-A1 gene by RIDER, S. H, BAILEY, C. J, VOSS, R, SHEER, D, HIORNS, L. R, SOLOMON, E

“…Images…”
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Ki-ras oncogene mutations in non-HPV-associated anal carcinoma by Hiorns, L R, Scholefield, J H, Palmer, J G, Shepherd, N A, Kerr, I B

“…Human papillomavirus 16 (HPV 16) DNA is found in a high proportion of anal squamous cell carcinomas in whose genesis it is thought to play an important role…”
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Abnormalities of Chromosomes 8, 11, 14, and X in T-Prolymphocytic Leukemia Studied by Fluorescence In Situ Hybridization by Maljaei, Seyed Hoda, Brito-Babapulle, Vasantha, Hiorns, Lynne R, Catovsky, Daniel

“…Twenty-one patients with T-prolymphocytic leukemia (T-PLL) were studied by FISH to characterize abnormalities of chromosomes 8, 11, 14, and X. A higher…”
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Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus by Kan, C C, Solomon, E, Belt, K T, Chain, A C, Hiorns, L R, Fey, G

“…Six alpha 2-macroglobulin (alpha 2M) cDNA clones were isolated from a human liver cDNA library by using synthetic oligonucleotides as hybridization probes. One…”
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Nucleotide Sequence of cDNA Encoding Human α2-macroglobulin and Assignment of the Chromosomal Locus by Kan, Chen-Chen, Solomon, Ellen, Belt, K. Tertia, Chain, Aileen C., Hiorns, Lynne R., Fey, Georg

“…Six α2-macroglobulin (α2M) cDNA clones were isolated from a human liver cDNA library by using synthetic oligonucleotides as hybridization probes. One of these,…”
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Bilineal Acute Leukemia of B and T Lineage with a Novel Translocation t(9;17)(p11;q11) by Zomas, Athanasios P., Swansbury, G. John, Matutes, Estella, Pinkerton, Ross, Morns, Lynne R., Min, Toon, Farahat, Nahla, Catovsky, Daniel

“…We describe a case of bilineal leukemia in a 5-year old boy with a rare immunophenotype and the novel translocation t(9;17)(p11;q11) as the sole chromosomal…”
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An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization by Hiorns, Lynne R., John Swansbury, G., Catovsky, Daniel

“…A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute…”
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Co-incident N and K ras gene mutations in a case of AML, restricted to differing cell lineages by Hiorns, L R, Cotter, F E, Young, B D

“…Peripheral blood from a patient with acute myeloid leukaemia (AML) of M5 FAB classification, was shown to have mutations to both the N and K ras genes…”
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Novel KI-ras codon 61 mutation in infiltrating leucocytes of oral squamous cell carcinoma by Chang, S E, Marnock, W E, Shirlaw, P J, Morgan, P R, Johnson, N W, Hiorns, L R, Young, B D

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