Search Results - "Hioki, Kou"

Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation by Temizoz, Burcu, Hioki, Kou, Kobari, Shingo, Jounai, Nao, Kusakabe, Takato, Lee, Michelle S J, Coban, Cevayir, Kuroda, Etsushi, Ishii, Ken J

“…Abstract Agonists for TLR9 and stimulator of IFN genes (STING) offer therapeutic applications as both anti-tumor agents and vaccine adjuvants, though their…”
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5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation by Temizoz, Burcu, Shibahara, Takayuki, Hioki, Kou, Hayashi, Tomoya, Kobiyama, Kouji, Lee, Michelle Sue Jann, Surucu, Naz, Sag, Erdal, Kumanogoh, Atsushi, Yamamoto, Masahiro, Gursel, Mayda, Ozen, Seza, Kuroda, Etsushi, Coban, Cevayir, Ishii, Ken J

“…5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity…”
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Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants by Hioki, Kou, Hayashi, Tomoya, Natsume-Kitatani, Yayoi, Kobiyama, Kouji, Temizoz, Burcu, Negishi, Hideo, Kawakami, Hitomi, Fuchino, Hiroyuki, Kuroda, Etsushi, Coban, Cevayir, Kawahara, Nobuo, Ishii, Ken J

“…Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune…”
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Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile by Zhuo, Shao-Hua, Noda, Naotaka, Hioki, Kou, Jin, Shuyu, Hayashi, Tomoya, Hiraga, Kou, Momose, Haruka, Li, Wen-Hao, Zhao, Lang, Mizukami, Takuo, Ishii, Ken J., Li, Yan-Mei, Uesugi, Motonari

“…Protein or peptide cancer vaccines usually include immune potentiators, so-called adjuvants. However, it remains challenging to identify structurally simple,…”
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A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models by Hioki, Kou, Castro Eiro, Melisa D., Li, Ling, Wilmsen, Merel E.P., Kiernan, Caoimhe H., Brouwers-Haspels, Inge, van Meurs, Marjan, de Vos, Kevin, Wildemans, Marlous, Zhao, Manzhi, de Wit, Harm, Grashof, Dwin G.B., van de Werken, Harmen J.G., Mueller, Yvonne M., Schliehe, Christopher, Ishii, Ken J., Katsikis, Peter D.

“…Abstract Immunotherapies such as immune checkpoint blockade (ICB) therapies have been developed in the last years as a promising strategy for the treatment of…”
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TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model by Castro Eiro, Melisa D, Hioki, Kou, Li, Ling, Wilmsen, Merel E P, Kiernan, Caoimhe H, Brouwers-Haspels, Inge, van Meurs, Marjan, Zhao, Manzhi, de Wit, Harm, Grashof, Dwin G B, van de Werken, Harmen J G, Mueller, Yvonne M, Schliehe, Christopher, Temizoz, Burcu, Kobiyama, Kouji, Ishii, Ken J, Katsikis, Peter D

“…Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies for the treatment of cancer; however, there remains a need to improve…”
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Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants by Jin, Shuyu, Vu, Hue Thi, Hioki, Kou, Noda, Naotaka, Yoshida, Hiroki, Shimane, Toru, Ishizuka, Shigenari, Takashima, Ippei, Mizuhata, Yoshiyuki, Beverly Pe, Kathleen, Ogawa, Tetsuya, Nishimura, Naoya, Packwood, Daniel, Tokitoh, Norihiro, Kurata, Hiroki, Yamasaki, Sho, Ishii, Ken J., Uesugi, Motonari

“…Immune potentiators, termed adjuvants, trigger early innate immune responses to ensure the generation of robust and long‐lasting adaptive immune responses of…”
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Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants by Jin, Shuyu, Vu, Hue Thi, Hioki, Kou, Noda, Naotaka, Yoshida, Hiroki, Shimane, Toru, Ishizuka, Shigenari, Takashima, Ippei, Mizuhata, Yoshiyuki, Beverly Pe, Kathleen, Ogawa, Tetsuya, Nishimura, Naoya, Packwood, Daniel, Tokitoh, Norihiro, Kurata, Hiroki, Yamasaki, Sho, Ishii, Ken J., Uesugi, Motonari

“…Immune potentiators, termed adjuvants, trigger early innate immune responses to ensure the generation of robust and long‐lasting adaptive immune responses of…”
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