Search Results - "Hintzen, RQ"

The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults by de Mol, CL, Wong, YYM, van Pelt, ED, Wokke, BHA, Siepman, TAM, Neuteboom, RF, Hamann, D, Hintzen, RQ

“…Objectives: The aim of this study was to assess the Dutch nationwide incidence of myelin oligodendrocyte glycoprotein (MOG)-IgG-associated acquired…”
Get full text

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects by Patsopoulos, Nikolaos A, Barcellos, Lisa F, Hintzen, Rogier Q, Schaefer, Catherine, van Duijn, Cornelia M, Noble, Janelle A, Raj, Towfique, Gourraud, Pierre-Antoine, Stranger, Barbara E, Oksenberg, Jorge, Olsson, Tomas, Taylor, Bruce V, Sawcer, Stephen, Hafler, David A, Carrington, Mary, De Jager, Philip L, de Bakker, Paul I W

“…The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect,…”
Get full text

A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking by TEUNISSEN, C. E, PETZOLD, A, HINTZEN, R. Q, HUGHES, S. G, JOHNSON, M. H, KRASULOVA, E, KUHLE, J, MAGNONE, M. C, RAJDA, C, REJDAK, K, SCHMIDT, H. K, VAN PESCH, V, BENNETT, J. L, WAUBANT, E, WOLF, C, GIOVANNONI, G, HEMMER, B, TUMANI, H, DEISENHAMMER, F, BERVEN, F. S, BRUNDIN, L, COMABELLA, M, FRANCIOTTA, D, FREDERIKSEN, J. L, FLEMING, J. O, FURLAN, R

“…There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are…”
Get full text

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis by Boven, Leonie A., Van Meurs, Marjan, Van Zwam, Marloes, Wierenga-Wolf, Annet, Hintzen, Rogier Q., Boot, Rolf G., Aerts, Johannes M., Amor, Sandra, Nieuwenhuis, Edward E., Laman, Jon D.

“…Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and axonal suffering. Pro-inflammatory myeloid cells contribute to…”
Get full text

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis by Van Broeckhoven, Christine, Dessa Sadovnick, A, Del-Favero, Jurgen, Greiner, Eva, van Duijn, Cornelia M, Oostra, Ben A, Goossens, Dirk, Hintzen, Rogier Q, Link, Jenny, Hoppenbrouwers, Ilse A, Broer, Linda, Ramagopalan, Sreeram V, Aulchenko, Yurii S, Hillert, Jan, Lundström, Wangko, Jafari, Naghmeh, Ebers, George C

“…The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679…”
Get full text

Effects of Natalizumab Treatment on the Cerebrospinal Fluid Proteome of Multiple Sclerosis Patients by Stoop, Marcel P, Singh, Vaibhav, Stingl, Christoph, Martin, Roland, Khademi, Mohsen, Olsson, Tomas, Hintzen, Rogier Q, Luider, Theo M

“…Natalizumab is a very effective, relatively new drug for the treatment of relapsing remitting multiple sclerosis. Inflammatory and neurodegenerative processes…”
Get full text

Disease course and outcome of acute disseminated encephalomyelitis is more severe in adults than in children by Ketelslegers, IA, Visser, IER, Neuteboom, RF, Boon, M, Catsman-Berrevoets, CE, Hintzen, RQ

“…Background: Acute disseminated encephalomyelitis (ADEM) affects children more frequently than adults. Current studies investigating ADEM in different age…”
Get full text

Response to Vilariño-Güell et al by Mescheriakova, JY, Verkerk, JMH, Amin, N, Uitterlinden, AG, van Duijn, CM, Hintzen, RQ

Get full text

Transfer of Central Nervous System Autoantigens and Presentation in Secondary Lymphoid Organs by de Vos, Alex F, van Meurs, Marjan, Brok, Herbert P, Boven, Leonie A, Hintzen, Rogier Q, van der Valk, Paul, Ravid, Rivka, Rensing, Susanne, Boon, Louis, Hart, Bert A. 't, Laman, Jon D

“…Dendritic cells are thought to regulate tolerance induction vs immunization by transferring Ags and peripheral signals to draining lymph nodes (LN). However,…”
Get full text

Prospective study on the relationship between infections and multiple sclerosis exacerbations by BULJEVAC, D, FLACH, H. Z, HOP, W. C. J, HIJDRA, D, LAMAN, J. D, SAVELKOUL, H. F. J, VAN DER MECHE, F. G. A, VAN DOORN, P. A, HINTZEN, R. Q

“…One of the characteristics of multiple sclerosis is the unpredictable occurrence of exacerbations and remissions. These fluctuations in disease activity are…”
Get full text

Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners by Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., van der Meché, F. G. A., Passchier, J., Hintzen, R. Q.

“…Objectives – Studies demonstrating reduced quality of life and psychological well‐being in multiple sclerosis (MS) have typically investigated patients within…”
Get full text

HLA-DRB1 and month of birth in multiple sclerosis by Ramagopalan, S V, Link, J, Byrnes, J K, Dyment, D A, Giovannoni, G, Hintzen, R Q, Sundqvist, E, Kockum, I, Smestad, C, Lie, B A, Harbo, H F, Padyukov, L, Alfredsson, L, Olsson, T, Sadovnick, A D, Hillert, J, Ebers, G C

“…Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of individuals being born in the spring and a deficit in the winter. This effect was…”
Get full text

Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis by Samijn, J P A, te Boekhorst, P A W, Mondria, T, van Doorn, P A, Flach, H Z, van der Meché, F G A, Cornelissen, J, Hop, W C, Löwenberg, B, Hintzen, R Q

“…Background: Certain stem cell transplantation procedures might slow down inflammatory pathology in multiple sclerosis (MS). Aims: To halt disease progression…”
Get full text

Expression and Release of CD27 in Human B-Cell Malignancies by van Oers, M.H.J., Pals, S.T., Evers, L.M., Schoot, C.E. van der, Koopman, G., Bonfrer, J.M.G., Hintzen, R.Q., Borne, A.E.G. Kr. von dem, Lier, R.A.W. van

“…CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in…”
Get full text

Modelling of multiple sclerosis: lessons learned in a non-human primate by 't Hart, Bert A, Laman, Jon D, Bauer, Jan, Blezer, Erwin, van Kooyk, Yvette, Hintzen, Rogier Q

“…The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between…”
Get more information

Epstein-Barr virus and disease activity in multiple sclerosis by Buljevac, D, van Doornum, G J J, Flach, H Z, Groen, J, Osterhaus, A D M E, Hop, W, van Doorn, P A, van der Meché, F G A, Hintzen, R Q

“…Objectives: To study in relapsing–remitting (RR) multiple sclerosis (MS) whether exacerbations and brain activity as measured by magnetic resonance imaging…”
Get full text

Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis by JANSSENS, A. C. J. W, VAN DOORN, P. A, DE BOER, J. B, KALKERS, N. F, VAN DER MECHE, F. G. A, PASSCHIER, J, HINTZEN, R. Q

“…Disability status, depression and anxiety are important determinants of quality of life (QoL) in patients with multiple sclerosis (MS). We investigated whether…”
Get full text

Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody by Hart, Bert A. 't, Brok, Herbert P. M, Remarque, Ed, Benson, Jacqueline, Treacy, George, Amor, Sandra, Hintzen, Rogier Q, Laman, Jon D, Bauer, Jan, Blezer, Erwin L. A

“…IL-12p40 is a shared subunit of two cytokines with overlapping activities in the induction of autoreactive Th1 cells and therefore a potential target of…”
Get full text

Difference in distribution of muscle weakness between myasthenia gravis and the Lambert–Eaton myasthenic syndrome by Wirtz, P W, Sotodeh, M, Nijnuis, M, van Doorn, P A, van Engelen, B G M, Hintzen, R Q, de Kort, P L M, Kuks, J B, Twijnstra, A, de Visser, M, Visser, L H, Wokke, J H, Wintzen, A R, Verschuuren, J J

“…Background: Myasthenia gravis and the Lambert–Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of…”
Get full text

Serum leptin levels during pregnancy in multiple sclerosis by Neuteboom, RF, Verbraak, E, Voerman, JSA, van Meurs, M, Steegers, EAP, de Groot, CJM, Laman, JD, Hintzen, RQ

“…Background Disease activity in patients with multiple sclerosis (MS) is suppressed during pregnancy, whereas attack frequency increases after delivery. It is…”
Get full text