Search Results - "Hintze, J"

MolProbity: More and better reference data for improved all‐atom structure validation by Williams, Christopher J., Headd, Jeffrey J., Moriarty, Nigel W., Prisant, Michael G., Videau, Lizbeth L., Deis, Lindsay N., Verma, Vishal, Keedy, Daniel A., Hintze, Bradley J., Chen, Vincent B., Jain, Swati, Lewis, Steven M., Arendall, W. Bryan, Snoeyink, Jack, Adams, Paul D., Lovell, Simon C., Richardson, Jane S., Richardson, David C.

“…This paper describes the current update on macromolecular model validation services that are provided at the MolProbity website, emphasizing changes and…”
Get full text

Molprobity's ultimate rotamer-library distributions for model validation by Hintze, Bradley J., Lewis, Steven M., Richardson, Jane S., Richardson, David C.

“…ABSTRACT Here we describe the updated MolProbity rotamer‐library distributions derived from an order‐of‐magnitude larger and more stringently quality‐filtered…”
Get full text

Antioxidants in Foods: State of the Science Important to the Food Industry by Finley, John W, Kong, Ah-Ng, Hintze, Korry J, Jeffery, Elizabeth H, Ji, Li Li, Lei, Xin Gen

“…Antioxidant foods and ingredients are an important component of the food industry. In the past, antioxidants were used primarily to control oxidation and…”
Get full text

Cellular regulation and molecular interactions of the ferritins by Hintze, K J, Theil, E C

“…Controlling iron/oxygen chemistry in biology depends on multiple genes, regulatory messenger RNA (mRNA) structures, signaling pathways and protein catalysts…”
Get full text

DNA and mRNA Elements with Complementary Responses to Hemin, Antioxidant Inducers, and Iron Control Ferritin-L Expression by Korry J. Hintze, Theil, Elizabeth C.

“…Ferritins, an ancient family of protein nanocages, concentrate iron in iron-oxy minerals for iron-protein biosynthesis and protection against oxy radical…”
Get full text

Model validation: local diagnosis, correction and when to quit by Richardson, Jane S., Williams, Christopher J., Hintze, Bradley J., Chen, Vincent B., Prisant, Michael G., Videau, Lizbeth L., Richardson, David C.

“…Traditionally, validation was considered to be a final gatekeeping function, but refinement is smoother and results are better if model validation actively…”
Get full text

Consumption of the Total Western Diet Promotes Colitis and Inflammation-Associated Colorectal Cancer in Mice by Benninghoff, Abby D, Hintze, Korry J, Monsanto, Stephany P, Rodriguez, Daphne M, Hunter, Ashli H, Phatak, Sumira, Pestka, James J, Wettere, Arnaud J Van, Ward, Robert E

“…Consumption of a Western type diet is a known risk factor for colorectal cancer. Our group previously developed the total Western diet (TWD) for rodents with…”
Get full text

Epidemiology and management of oral cavity squamous cell carcinoma in Ireland by Sexton, Gerard P., Hintze, J.M., Walsh, Paul, Moriarty, Frank, Lennon, Paul, Fitzgerald, Conall W.R., O'Neill, James Paul

“…The epidemiology and management of oral cavity cancer have changed considerably in recent decades. This study examines epidemiological and management trends in…”
Get full text

Formulation of the Total Western Diet (TWD) as a Basal Diet for Rodent Cancer Studies by Hintze, Korry J, Benninghoff, Abby D, Ward, Robert E

“…Rodent cancer studies typically use defined diets with nutrient profiles optimized for rodent health. However, a defined rodent diet that represents typical…”
Get full text

Factors affecting Naseptin treatment success – A prospective cohort study by Garry, S., Wauchope, J., Hintze, J.M., Ryan, E.J., O'Cathain, E., Heffernan, C.B.

“…To assess patient factors to predict treatment success of Naseptin for recurrent paediatric epistaxis. This prospective cohort study of paediatric patients…”
Get full text

Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring by Mjaaseth, Ulrik N, Norris, Jackson C, Aardema, Niklas D J, Bunnell, Madison L, Ward, Robert E, Hintze, Korry J, Cho, Clara E

“…Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not in female, offspring…”
Get full text

Chemoradiation treatment patterns among United States Veteran Health Administration patients with unresectable stage III non-small cell lung cancer by Hung, Anna, Lee, Kyung Min, Lynch, Julie A, Li, Yanhong, Poonnen, Pradeep, Efimova, Olga V, Hintze, Bradley J, Buckingham, Trudy, Yong, Candice, Seal, Brian, Kelley, Michael J, Reed, Shelby D

“…Abstract Background The Veterans Health Administration (VHA) is the largest integrated health care system in the United States (US). Among VHA patients, the…”
Get full text

Basal Diet Determined Long-Term Composition of the Gut Microbiome and Mouse Phenotype to a Greater Extent than Fecal Microbiome Transfer from Lean or Obese Human Donors by Rodriguez, Daphne M, Benninghoff, Abby D, Aardema, Niklas D J, Phatak, Sumira, Hintze, Korry J

“…The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic disorders. To examine the interactions between diet, the microbiome,…”
Get full text

The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing by Jackson, Ryan N, Klauer, A Alejandra, Hintze, Bradley J, Robinson, Howard, van Hoof, Ambro, Johnson, Sean J

“…The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for…”
Get full text

Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer by Hintze, Korry J, Cox, James E, Rompato, Giovanni, Benninghoff, Abby D, Ward, Robert E, Broadbent, Jeff, Lefevre, Michael

“…Traditionally, mouse humanization studies have used human fecal transfer to germ-free animals. This practice requires gnotobiotic facilities and is restricted…”
Get full text

Tracheostomy stomal seeding following oral cavity resection by Hintze, J.M., Fitzgerald, C., Lang, B., O'Shea, J., Barry, C., Brennan, S., Lennon, P.

“…Tracheal stoma recurrence following oral cavity surgery is exceedingly rare. Although several different mechanisms for this have been described, the…”
Get full text

Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet by Rodriguez, Daphne M, Hintze, Korry J, Rompato, Giovanni, Wettere, Arnaud J Van, Ward, Robert E, Phatak, Sumira, Neal, Canyon, Armbrust, Tess, Stewart, Eliza C, Thomas, Aaron J, Benninghoff, Abby D

“…Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would…”
Get full text

The Western Dietary Pattern Combined with Vancomycin-Mediated Changes to the Gut Microbiome Exacerbates Colitis Severity and Colon Tumorigenesis by Aardema, Niklas D, Rodriguez, Daphne M, Van Wettere, Arnaud J, Benninghoff, Abby D, Hintze, Korry J

“…Previous work by our group using a mouse model of inflammation-associated colorectal cancer (CAC) showed that the total Western diet (TWD) promoted colon tumor…”
Get full text

Resistant Potato Starch Alters the Cecal Microbiome and Gene Expression in Mice Fed a Western Diet Based on NHANES Data by Smith, Allen D, Chen, Celine, Cheung, Lumei, Ward, Robert, Hintze, Korry J, Dawson, Harry D

“…Several studies indicate that the four major types of resistant starch (RS1-4) are fermented in the cecum and colon to produce short-chain fatty acids (SCFAs)…”
Get full text

Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease by Rodriguez, Daphne M, Hintze, Korry J, Rompato, Giovanni, Stewart, Eliza C, Barton, Abbey H, Mortensen-Curtis, Emily, Green, Porter A, Van Wettere, Arnaud J, Thomas, Aaron J, Benninghoff, Abby D

“…Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter fecal microbiome…”
Get full text