Search Results - "Hinton, R."

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration by Ishikawa, Keijiro, Kannan, Ram, Hinton, David R.

“…Subretinal fibrosis is a result of a wound healing response that follows choroidal neovascularization in neovascular age-related macular degeneration (nAMD)…”
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Can redshift errors bias measurements of the Hubble Constant? by Davis, Tamara M, Hinton, Samuel R, Howlett, Cullan, Calcino, Josh

“…ABSTRACT Redshifts have been so easy to measure for so long that we tend to neglect the fact that they too have uncertainties and are susceptible to systematic…”
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Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants by Ku, Zhiqiang, Xie, Xuping, Hinton, Paul R., Liu, Xinli, Ye, Xiaohua, Muruato, Antonio E., Ng, Dean C., Biswas, Sujit, Zou, Jing, Liu, Yang, Pandya, Deepal, Menachery, Vineet D., Rahman, Sachi, Cao, Yu-An, Deng, Hui, Xiong, Wei, Carlin, Kevin B., Liu, Junquan, Su, Hang, Haanes, Elizabeth J., Keyt, Bruce A., Zhang, Ningyan, Carroll, Stephen F., Shi, Pei-Yong, An, Zhiqiang

“…Resistance represents a major challenge for antibody-based therapy for COVID-19 1 – 4 . Here we engineered an immunoglobulin M (IgM) neutralizing antibody…”
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Dynamics of Supramolecular Self-Healing Recovery in Extension by Hinton, Zachary R, Shabbir, Aamir, Alvarez, Nicolas J

“…Self-healing materials are prized for their ability to recover mechanical properties after damage. Supramolecular polymer networks have been demonstrated to…”
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The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction by Sreekumar, Parameswaran G, Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H, Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death,…”
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Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione by Matsunaga, Douglas, Sreekumar, Parameswaran G, Ishikawa, Keijiro, Terasaki, Hiroto, Barron, Ernesto, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE)…”
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Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina by Shi, Haoshen, Koronyo, Yosef, Rentsendorj, Altan, Regis, Giovanna C., Sheyn, Julia, Fuchs, Dieu-Trang, Kramerov, Andrei A., Ljubimov, Alexander V., Dumitrascu, Oana M., Rodriguez, Anthony R., Barron, Ernesto, Hinton, David R., Black, Keith L., Miller, Carol A., Mirzaei, Nazanin, Koronyo-Hamaoui, Maya

“…Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown…”
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The unfolded protein response regulator GRP78 BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells by Li, J, Ni, M, Lee, B, Barron, E, Hinton, D R, Lee, A S

“…In mammalian cells, endoplasmic reticulum (ER) stress has recently been shown to induce autophagy and the induction requires the unfolded protein response…”
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Stem cell based therapies for age-related macular degeneration: The promises and the challenges by Nazari, Hossein, Zhang, Li, Zhu, Danhong, Chader, Gerald J., Falabella, Paulo, Stefanini, Francisco, Rowland, Teisha, Clegg, Dennis O., Kashani, Amir H., Hinton, David R., Humayun, Mark S.

“…Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. AMD is classified as either neovascular…”
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Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer by Diniz, Bruno, Thomas, Padmaja, Thomas, Biju, Ribeiro, Ramiro, Hu, Yuntao, Brant, Rodrigo, Ahuja, Ashish, Zhu, Danhong, Liu, Laura, Koss, Michael, Maia, Mauricio, Chader, Gerald, Hinton, David R, Humayun, Mark S

“…To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised…”
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Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair by Hinton, R.J., Jing, Y., Jing, J., Feng, J.Q.

“…The formation of the mandibular condylar cartilage (MCC) and its subchondral bone is an important but understudied topic in dental research. The current…”
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The Emerging Role of Senescence in Ocular Disease by Sreekumar, Parameswaran G., Kannan, Ram, Hinton, David R.

“…Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown…”
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Apatite: A new redox proxy for silicic magmas? by Miles, A.J., Graham, C.M., Hawkesworth, C.J., Gillespie, M.R., Hinton, R.W., Bromiley, G.D.

“…The oxidation states of magmas provide valuable information about the release and speciation of volatile elements during volcanic eruptions, metallogenesis,…”
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Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration by Kannan, Ram, Sreekumar, Parameswaran G., Hinton, David R.

“…αA- and αB crystallins are principal members of the small heat shock protein family and elicit both a cell protective function and a chaperone function…”
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Attitudes and perceptions about breastfeeding among female and male informal workers in India and South Africa by Horwood, C, Surie, A, Haskins, L, Luthuli, S, Hinton, R, Chowdhury, A, Rollins, N

“…Worldwide, over 740 million women make their living in the informal economy and therefore lack formal employment benefits, such as maternity leave, that can…”
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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity by Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, Ambati, Jayakrishna

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that…”
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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 by Tarallo, Valeria, Hirano, Yoshio, Gelfand, Bradley D., Dridi, Sami, Kerur, Nagaraj, Kim, Younghee, Cho, Won Gil, Kaneko, Hiroki, Fowler, Benjamin J., Bogdanovich, Sasha, Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, Gautam, Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Yuichiro, Yoo, Jae Wook, Lee, Dong-ki, Provost, Patrick, Hinton, David R., Núñez, Gabriel, Baffi, Judit Z., Kleinman, Mark E., Ambati, Jayakrishna

“…Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form…”
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Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells by Kannan, Ram, Hinton, David R., Sreekumar, Parameswaran G., Minasyan, Leonid

“…Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the…”
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A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells by Hinton, David R, Sonoda, Shozo, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Kannan, Ram

“…We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly…”
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Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy by Ishikawa, Keijiro, He, Shikun, Terasaki, Hiroto, Nazari, Hossein, Zhang, Huiming, Spee, Christine, Kannan, Ram, Hinton, David R

“…Proliferative vitreoretinopathy (PVR) is a serious complication of retinal detachment and ocular trauma and its recurrence may lead to irreversible vision…”
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