Search Results - "Hinton, David"

Microplastics in Small Waterbodies and Tadpoles from Yangtze River Delta, China by Hu, Lingling, Chernick, Melissa, Hinton, David E, Shi, Huahong

“…Although microplastic (MP) pollution in freshwater systems is gaining attention, our knowledge of its distribution in small waterbodies is scarce. Small…”
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Chronic microfiber exposure in adult Japanese medaka (Oryzias latipes) by Hu, Lingling, Chernick, Melissa, Lewis, Anna M, Ferguson, P Lee, Hinton, David E

“…Microplastic fibers (MFs) pollute aquatic habitats globally via sewage release, stormwater runoff, or atmospheric deposition. Of the synthetic MFs, polyester…”
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Chronic dietary exposure to polystyrene microplastics in maturing Japanese medaka (Oryzias latipes) by Zhu, Mei, Chernick, Melissa, Rittschof, Daniel, Hinton, David E.

“…•10-week dietary exposure to polystyrene microspheres from juvenile to adult medaka.•Did not reduce growth or affect normal maturation.•Dose dependent decrease…”
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Molecular mechanisms of subretinal fibrosis in age-related macular degeneration by Ishikawa, Keijiro, Kannan, Ram, Hinton, David R.

“…Subretinal fibrosis is a result of a wound healing response that follows choroidal neovascularization in neovascular age-related macular degeneration (nAMD)…”
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Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione by Matsunaga, Douglas, Sreekumar, Parameswaran G, Ishikawa, Keijiro, Terasaki, Hiroto, Barron, Ernesto, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE)…”
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Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos by Fang, Mingliang, Guo, Jiehong, Chen, Da, Li, An, Hinton, David E., Dong, Wu

“…Halogenated carbazoles are increasingly identified as a novel class of environmental contaminants. However, no in vivo acute toxicity information on those…”
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The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction by Sreekumar, Parameswaran G, Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H, Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death,…”
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Microplastics decrease the toxicity of triphenyl phosphate (TPhP) in the marine medaka (Oryzias melastigma) larvae by Zhang, Yu Ting, Chen, Mengyun, He, Shuiqing, Fang, Chao, Chen, Mingliang, Li, Dan, Wu, Dong, Chernick, Melissa, Hinton, David E., Bo, Jun, Xie, Lingtian, Mu, Jingli

“…Plastics have been recognized as a serious threat to the environment. Besides their own toxicity, microplastics can interact with other environmental…”
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Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina by Shi, Haoshen, Koronyo, Yosef, Rentsendorj, Altan, Regis, Giovanna C., Sheyn, Julia, Fuchs, Dieu-Trang, Kramerov, Andrei A., Ljubimov, Alexander V., Dumitrascu, Oana M., Rodriguez, Anthony R., Barron, Ernesto, Hinton, David R., Black, Keith L., Miller, Carol A., Mirzaei, Nazanin, Koronyo-Hamaoui, Maya

“…Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown…”
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αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells by Sreekumar, Parameswaran G, Kannan, Ram, Kitamura, Mizuki, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Hinton, David R

“…αB crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and has been identified as a biomarker in age-related macular…”
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Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD by Sreekumar, Parameswaran G., Reddy, Srinivasa T., Hinton, David R., Kannan, Ram

“…Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction and is likely a causative factor in the pathogenesis of…”
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Protection of retina by αB crystallin in sodium iodate induced retinal degeneration by Zhou, Peng, Kannan, Ram, Spee, Christine, Sreekumar, Parameswaran G, Dou, Guorui, Hinton, David R

“…Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of…”
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Stem cell based therapies for age-related macular degeneration: The promises and the challenges by Nazari, Hossein, Zhang, Li, Zhu, Danhong, Chader, Gerald J., Falabella, Paulo, Stefanini, Francisco, Rowland, Teisha, Clegg, Dennis O., Kashani, Amir H., Hinton, David R., Humayun, Mark S.

“…Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. AMD is classified as either neovascular…”
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Novel roles for α-crystallins in retinal function and disease by Kannan, Ram, Sreekumar, Parameswaran G., Hinton, David R.

“…α-Crystallins are key members of the superfamily of small heat shock proteins that have been studied in detail in the ocular lens. Recently, novel functions…”
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Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer by Diniz, Bruno, Thomas, Padmaja, Thomas, Biju, Ribeiro, Ramiro, Hu, Yuntao, Brant, Rodrigo, Ahuja, Ashish, Zhu, Danhong, Liu, Laura, Koss, Michael, Maia, Mauricio, Chader, Gerald, Hinton, David R, Humayun, Mark S

“…To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised…”
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The Emerging Role of Senescence in Ocular Disease by Sreekumar, Parameswaran G., Kannan, Ram, Hinton, David R.

“…Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown…”
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Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration by Kannan, Ram, Sreekumar, Parameswaran G., Hinton, David R.

“…αA- and αB crystallins are principal members of the small heat shock protein family and elicit both a cell protective function and a chaperone function…”
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Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging by Saraswathy, Sindhu, Tan, James C H, Yu, Fei, Francis, Brian A, Hinton, David R, Weinreb, Robert N, Huang, Alex S

“…Trabecular meshwork (TM) bypass surgeries attempt to enhance aqueous humor outflow (AHO) to lower intraocular pressure (IOP). While TM bypass results are…”
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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity by Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, Ambati, Jayakrishna

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that…”
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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 by Tarallo, Valeria, Hirano, Yoshio, Gelfand, Bradley D., Dridi, Sami, Kerur, Nagaraj, Kim, Younghee, Cho, Won Gil, Kaneko, Hiroki, Fowler, Benjamin J., Bogdanovich, Sasha, Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, Gautam, Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Yuichiro, Yoo, Jae Wook, Lee, Dong-ki, Provost, Patrick, Hinton, David R., Núñez, Gabriel, Baffi, Judit Z., Kleinman, Mark E., Ambati, Jayakrishna

“…Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form…”
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