Search Results - "Hinton, Cimona V"

Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain by Hinton, Cimona V, Avraham, Shalom, Avraham, Hava Karsenty

“…Breast cancer is the most common malignancy and second leading cause of cancer death in women. Ninety percent of mortality in breast cancer is often associated…”
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Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells by Don-Salu-Hewage, Ayesha S, Chan, Siu Yuen, McAndrews, Kathleen M, Chetram, Mahandranauth A, Dawson, Michelle R, Bethea, Danaya A, Hinton, Cimona V

“…The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded…”
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ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells by Chetram, Mahandranauth A., Bethea, Danaya A., Odero-Marah, Valerie A., Don-Salu-Hewage, Ayesha S., Jones, Kia J., Hinton, Cimona V.

“…Reactive oxygen species (ROS) play a central role in oxidative stress, which leads to the onset of diseases, such as cancer. Furthermore, ROS contributes to…”
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Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells by Chetram, Mahandranauth A, Odero-Marah, Valerie, Hinton, Cimona V

“…Loss of PTEN is frequently observed in androgen-independent prostate cancer, resulting in the deregulation of metastatic events. SDF1α activation of CXCR4…”
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Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models by Bai, Lijuan, Li, Xin, Yang, Yang, Zhao, Rui, White, Elshaddai Z., Danaher, Alira, Bowen, Nathan J., Hinton, Cimona V., Cook, Nicholas, Li, Dehong, Wu, Alyssa Y., Qui, Min, Du, Yuhong, Fu, Haian, Kucuk, Omer, Wu, Daqing

“…•Chemoresistance is a major obstacle in the management of advanced prostate cancer.•Bromocriptine has high specificity and potency in chemoresistant prostate…”
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Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells by Campbell, Taaliah, Hawsawi, Ohuod, Henderson, Veronica, Dike, Precious, Hwang, Bor-Jang, Liadi, Yusuf, White, ElShaddai Z., Zou, Jin, Wang, GuangDi, Zhang, Qiang, Bowen, Nathan, Scott, Derrick, Hinton, Cimona V., Odero-Marah, Valerie

“…Oxidative stress is increased in several cancers including prostate cancer, and is currently being exploited in cancer therapy to induce ferroptosis, a novel…”
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p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines by Chang, Megan A., Morgado, Micaela, Warren, Curtis R., Hinton, Cimona V., Farach-Carson, Mary C., Delk, Nikki A.

“…BACKGROUND Bone marrow stromal cell (BMSC) paracrine factor(s) can induce apoptosis in bone metastatic prostate cancer (PCa) cell lines. However, the PCa cells…”
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Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells by White, ElShaddai Z., Pennant, Nakea M., Carter, Jada R., Hawsawi, Ohuod, Odero-Marah, Valerie, Hinton, Cimona V.

“…Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metabolism. Oxidative stress serves as a…”
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Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression by Coke, Christopher J., Scarlett, Kisha A., Chetram, Mahandranauth A., Jones, Kia J., Sandifer, Brittney J., Davis, Ahriea S., Marcus, Adam I., Hinton, Cimona V.

“…The G-protein-coupled chemokine receptor CXCR4 generates signals that lead to cell migration, cell proliferation, and other survival mechanisms that result in…”
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The evolution of cannabinoid receptors in cancer by Pennant, Nakea M., Hinton, Cimona V.

“…Cannabis sativa (cannabis) has been used as a therapeutic treatment for centuries treating various diseases and disorders. However, racial propaganda led to…”
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PTEN regulation of ERK1/2 signaling in cancer by Chetram, Mahandranauth A., Hinton, Cimona V.

“…Since its discovery, the tumor suppressor phosphatase and tensin homolog (PTEN) has become a molecule with a wide spectrum of functions, which is typically…”
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Abstract 4574: C-X-C chemokine receptor 4 and cannabinoid receptor 2 interact to abrogate CXCL12-mediated cellular response by Coke, Christopher, Scarlett, Kisha, Jones, Kia, Hinton, Cimona V.

“…Abstract Expression of C-X-C Chemokine Receptor 4 (CXCR4) encourages tumors cells to migrate to distal organs expressing its cognate ligand, CXCL12, thus…”
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ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells by Chetram, Mahandranauth A., Don-Salu-Hewage, Ayesha S., Hinton, Cimona V.

“…► ROS increased phospho-AKT and CXCR4 expression in prostate cancer cells. ► ROS mediated PTEN inactivation, but did not affect expression. ► ROS enhanced cell…”
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Abstract 4572: Simultaneous activation of C-X-C chemokine receptor 4 and cannabinoid receptor 2 leads to decreased Rho-induced prostate cancer metastasis by Scarlett, Kisha A., Coke, Christopher J., Fennell, Imani, Hinton, Cimona V.

“…Abstract BACKGROUND: The binding of the homeostatic chemokine SDF-1 to the G -protein-coupled receptor C-X-C Chemokine Receptor 4 (CXCR4) induces cell…”
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Research Infrastructure Core Facilities at Research Centers in Minority Institutions: Part I-Research Resources Management, Operation, and Best Practices by Tchounwou, Paul B, Malouhi, Mohamad, Ofili, Elizabeth O, Fernández-Repollet, Emma, Sarpong, Daniel F, Yanagihara, Richard, Aguilera, Renato J, Ayón, Cecilia, Chen, Xiaoxin, Dasmahapatra, Asok, Gao, Song, Hinton, Cimona V, Holt, Robert, Kolesnichenko, Vladimir, Powell, Michael D, Merchant, Fatima, Redda, Kinfe K, Roche-Lima, Abiel, Shikuma, Cecilia M, Stevens, Jacqueline J, Torres, Jose A, Trotter, Robert T, Wachira, James, Wang, Paul, Wells, Kristen J, White, Jason, Wu, Yanyuan

“…Funded by the National Institutes of Health (NIH), the Research Centers in Minority Institutions (RCMI) Program fosters the development and implementation of…”
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Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration by Scarlett, Kisha A, White, El-Shaddai Z, Coke, Christopher J, Carter, Jada R, Bryant, Latoya K, Hinton, Cimona V

“…G-protein-coupled receptor (GPCR) heterodimerization has emerged as a means by which alternative signaling entities can be created; yet, how receptor…”
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ROS-mediated regulation of CXCR4 in cancer by Chetram, Mahandranauth A., Hinton, Cimona V.

“…Oxidative stress and the accumulation of reactive oxygen specie （ROS） play a role in cancer cells developing an advanced, phenotypic signature that associates…”
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Contributions of integrin‐linked kinase to breast cancer metastasis and tumourigenesis by Hinton, Cimona V., Avraham, Shalom, Avraham, Hava Karsenty

“…•  Introduction ‐  Role of integrins in tumourigenesis ‐  Role of integrins in signalling •  Integrin‐linked kinase (ILK) ‐  ILK and binding complexes •  ILK…”
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Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells by Jones, Kia J., Chetram, Mahandranauth A., Bethea, Danaya A., Bryant, Latoya K., Odero-Marah, Valerie, Hinton, Cimona V.

“…Reactive oxygen species (ROS) are implicated in many human diseases, including cancer. We have previously demonstrated that ROS increased the expression and…”
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Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1 by Hinton, Cimona V., Fitzgerald, Latricia D., Thompson, Marilyn E.

“…Signaling pathways involved in regulating nuclear–cytoplasmic distribution of BRCA1 have not been previously reported. Here, we provide evidence that heregulin…”
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