Search Results - "Hinshelwood, Margaret M"

Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans by Kamat, Amrita, Hinshelwood, Margaret M, Murry, Barbara A, Mendelson, Carole R

“…In humans, aromatase P450, which catalyses conversion of C 19-steroids to estrogens, is expressed in several tissues, including gonads, brain, adipose tissue,…”
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Transcriptional regulation of aromatase in placenta and ovary by Mendelson, Carole R., Jiang, Bing, Shelton, John M., Richardson, James A., Hinshelwood, Margaret M.

“…Our goal is to define the cellular and molecular mechanisms for tissue- and cell-specific, developmental and hormonal regulation of the human CYP19 (aromatase…”
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Temporal and spatial expression of liver receptor homologue‐1 (LRH‐1) during embryogenesis suggests a potential role in gonadal development by Hinshelwood, Margaret M., Shelton, John M., Richardson, James A., Mendelson, Carole R.

“…Liver receptor homologue‐1 (LRH‐1), an orphan member of the nuclear receptor family highly expressed in adult mouse ovary, is closely related to steroidogenic…”
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Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies by Zhrebker, Leah, Cherni, Irene, Gross, Lara M, Hinshelwood, Margaret M, Reese, Merrick, Aldrich, Jessica, Guileyardo, Joseph M, Roberts, William C, Craig, David, Von Hoff, Daniel D, Mennel, Robert G, Carpten, John D

“…Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced…”
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Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function by Hinshelwood, Margaret M., Repa, Joyce J., Shelton, John M., Richardson, James A., Mangelsdorf, David J., Mendelson, Carole R.

“…Steroid biosynthesis in ovary is enhanced by the orphan nuclear receptor, steroidogenic factor-1 (SF-1); however, we reported that liver receptor homolog-1…”
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The farnesoid X receptor regulates transcription of 3β-hydroxysteroid dehydrogenase type 2 in human adrenal cells by Xing, Yewei, Saner-Amigh, Karla, Nakamura, Yasuhiro, Hinshelwood, Margaret M., Carr, Bruce R., Mason, J. Ian, Rainey, William E.

“…Recent studies have shown that the adrenal cortex expresses high levels of farnesoid X receptor (FXR), but its function remains unknown. Herein, using…”
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Estrogen Related Receptor-α Enhances Surfactant Protein-A Gene Expression in Fetal Lung Type II Cells by Liu, Dongyuan, Hinshelwood, Margaret M, Giguère, Vincent, Mendelson, Carole R

“…Surfactant protein-A (SP-A) gene expression is developmentally regulated in fetal lung type II cells in concert with surfactant glycerophospholipid synthesis…”
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A 278 bp Region Just Upstream of the Human CYP19 (Aromatase) Gene Mediates Ovary-Specific Expression in Transgenic Mice by Hinshelwood, Margaret M, Smith, Margaret E, Murry, Barbara A, Mendelson, Carole R

“…ABSTRACT In humans, the CYP19 gene, which encodes aromatase P450, is expressed in a number of tissues including gonads, adipose, bone, and placenta. The…”
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Tissue-specific expression of the human CYP19 (aromatase) gene in ovary and adipose tissue of transgenic mice by Hinshelwood, Margaret M, Mendelson, Carole R

“…In humans, the CYP19 (aromatase P450) gene is expressed in a number of tissues, including gonads, placenta, adipose tissue, skin and brain. The 5′-untranslated…”
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The 5′-Flanking Region of the Ovarian Promoter of the Bovine CYP19 Gene Contains a Deletion in a Cyclic Adenosine 3′,5′-Monophosphate-Like Responsive Sequence by Hinshelwood, Margaret M., Michael, M. Dodson, Simpson, Evan R.

“…Abstract Conversion of C19 steroids to estrogens is catalyzed by aromatase P450 (P450arom; the product of the CYP19 gene). In the ovary, P450arom is expressed…”
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A Putative Binding Site for Sp1 Is Involved in Transcriptional Regulation of CYP17 Gene Expression in Bovine Ovary by Borroni, Raffaella, Liu, Zheng, Simpson, Evan R., Hinshelwood, Margaret M.

“…Abstract In the bovine ovary, thecal cells are the only cell type capable of expressing the CYP17 gene in response to LH. With the onset of ovulation and…”
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Acute care model that reduces oncology-related unplanned hospitalizations to promote quality of care and reduce cost by Coyle, Yvonne M., Ogola, Gerald O., MacLachlan, Carl R., Hinshelwood, Margaret M., Fleming, Neil S.

“…•Acute hospital-based care can be high cost and potentially lower quality of care.•Unplanned hospitalizations are potentially preventable.•Evidence-based acute…”
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Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis by Simpson, E R, Mahendroo, M S, Means, G D, Kilgore, M W, Hinshelwood, M M, Graham-Lorence, S, Amarneh, B, Ito, Y, Fisher, C R, Michael, M D

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The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells by Xing, Yewei, Saner-Amigh, Karla, Nakamura, Yasuhiro, Hinshelwood, Margaret M, Carr, Bruce R, Mason, J Ian, Rainey, William E

“…Recent studies have shown that the adrenal cortex expresses high levels of farnesoid X receptor (FXR), but its function remains unknown. Herein, using…”
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Expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage by Simpson, Evan R., Michael, M. Dodson, Agarwal, Veena R., Hinshelwood, Margaret M., Bulun, Serdar E., Zhao, Ying

“…Family 19 of the P450 super family is responsible for the conversion of C19 androgenic steroids to the corresponding estrogens, a reaction known as…”
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Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells by NOBLE, L. S, TAKAYAMA, K, ZEITOUN, K. M, PUTMAN, J. M, JOHNS, D. A, HINSHELWOOD, M. M, AGARWAL, V. R, ZHAO, Y, CARR, B. R, BULUN, S. E

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Endocrine disorders associated with inappropriately high aromatase expression by Bulun, Serdar E., Noble, Luis S., Takayama, Kazuto, Michael, M.Dodson, Agarwal, Veena, Fisher, Carolyn, Zhao, Ying, Hinshelwood, Margaret M., Ito, Yuji, Simpson, Evan R.

“…Aromatase P450 (P450 arom) is responsible for conversion of C 19 steroids to estrogens in a number of human tissues, such as the placenta, gonads, adipose…”
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Aromatase expression in health and disease by Simpson, E R, Zhao, Y, Agarwal, V R, Michael, M D, Bulun, S E, Hinshelwood, M M, Graham-Lorence, S, Sun, T, Fisher, C R, Qin, K, Mendelson, C R

“…Family 19 of the P450 superfamily is responsible for the conversion of C19 androgenic steroids to the corresponding estrogens, a reaction known as…”
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The 5′-Flanking Region of the Ovarian Promoter of the Bovine CYP19 Gene Contains a Deletion in a Cyclic Adenosine 3′,5′-Monophosphate-Like Responsive Sequence1 by Hinshelwood, Margaret M, Michael, M. Dodson, Simpson, Evan R

“…Conversion of C19 steroids to estrogens is catalyzed by aromatase P450 (P450arom; the product of the CYP19 gene). In the ovary, P450arom is expressed in…”
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A Putative Binding Site for Sp1 Is Involved in Transcriptional Regulation of CYP17 Gene Expression in Bovine Ovary1 by Borroni, Raffaella, Liu, Zheng, Simpson, Evan R, Hinshelwood, Margaret M

“…In the bovine ovary, thecal cells are the only cell type capable of expressing the CYP17 gene in response to LH. With the onset of ovulation and luteinization…”
Get full text