Search Results - "Hinshaw, Stephen M."

The structure of the Ctf19c/CCAN from budding yeast by Hinshaw, Stephen M, Harrison, Stephen C

“…Eukaryotic kinetochores connect spindlemicrotubules to chromosomal centromeres. A group of proteins called the Ctf19 complex (Ctf19c) in yeast and the…”
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The Kinetochore Receptor for the Cohesin Loading Complex by Hinshaw, Stephen M., Makrantoni, Vasso, Harrison, Stephen C., Marston, Adèle L.

“…The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages…”
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An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation by Hinshaw, Stephen M., Harrison, Stephen C.

“…Accurate segregation of genetic material in eukaryotes relies on the kinetochore, a multiprotein complex that connects centromeric DNA with microtubules. In…”
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Recognition of Divergent Viral Substrates by the SARS-CoV‑2 Main Protease by MacDonald, Elizabeth A, Frey, Gary, Namchuk, Mark N, Harrison, Stephen C, Hinshaw, Stephen M, Windsor, Ian W

“…The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), is an ideal target for…”
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The structure of the yeast Ctf3 complex by Hinshaw, Stephen M, Dates, Andrew N, Harrison, Stephen C

“…Kinetochores are the chromosomal attachment points for spindle microtubules. They are also signaling hubs that control major cell cycle transitions and…”
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Structural evidence for Scc4-dependent localization of cohesin loading by Hinshaw, Stephen M, Makrantoni, Vasso, Kerr, Alastair, Marston, Adèle L, Harrison, Stephen C

“…The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a…”
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Kinetochore Function from the Bottom Up by Hinshaw, Stephen M, Harrison, Stephen C

“…During a single human lifetime, nearly one quintillion chromosomes separate from their sisters and transit to their destinations in daughter cells. Unlike DNA…”
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The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T by Hinshaw, Stephen M., Harrison, Stephen C.

“…Chromosome segregation depends on a regulated connection between spindle microtubules and centromeric DNA. The kinetochore mediates this connection and ensures…”
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Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly by Hinshaw, Stephen M., Quan, Yun, Cai, Jiaxi, Zhou, Ann L., Zhou, Huilin

“…Kinetochores control eukaryotic chromosome segregation by connecting chromosomal centromeres to spindle microtubules. Duplication of centromeric DNA…”
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Lactate regulates cell cycle by remodelling the anaphase promoting complex by Liu, Weihai, Wang, Yun, Bozi, Luiz H. M., Fischer, Patrick D., Jedrychowski, Mark P., Xiao, Haopeng, Wu, Tao, Darabedian, Narek, He, Xiadi, Mills, Evanna L., Burger, Nils, Shin, Sanghee, Reddy, Anita, Sprenger, Hans-Georg, Tran, Nhien, Winther, Sally, Hinshaw, Stephen M., Shen, Jingnan, Seo, Hyuk-Soo, Song, Kijun, Xu, Andrew Z., Sebastian, Luke, Zhao, Jean J., Dhe-Paganon, Sirano, Che, Jianwei, Gygi, Steven P., Arthanari, Haribabu, Chouchani, Edward T.

“…Lactate is abundant in rapidly dividing cells owing to the requirement for elevated glucose catabolism to support proliferation 1 – 6 . However, it is not…”
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Recognition of centromere‐specific histone Cse4 by the inner kinetochore Okp1‐Ame1 complex by Deng, Sunbin, Cai, Jiaxi, Harrison, Stephen C, Zhou, Huilin, Hinshaw, Stephen M

“…Successful mitosis depends on the timely establishment of correct chromosomal attachments to microtubules. The kinetochore, a modular multiprotein complex,…”
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Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase by Kim, Younghoon, Seo, Pooreum, Jeon, Eunhye, You, Inchul, Hwang, Kyubin, Kim, Namkyoung, Tse, Jason, Bae, Juhyeon, Choi, Ha-Soon, Hinshaw, Stephen M, Gray, Nathanael S, Sim, Taebo

“…Chemically induced protein degradation is a powerful strategy for perturbing cellular biochemistry. The predominant mechanism of action for protein degrader…”
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Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore by Quan, Yun, Hinshaw, Stephen M, Wang, Pang-Che, Harrison, Stephen C, Zhou, Huilin

“…The step-by-step process of chromosome segregation defines the stages of the cell cycle. In eukaryotes, signals controlling these steps converge upon the…”
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Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry by Sarott, Roman C., You, Inchul, Li, Yen-Der, Toenjes, Sean T., Donovan, Katherine A., Seo, Pooreum, Ordonez, Martha, Byun, Woong Sub, Hassan, Muhammad Murtaza, Wachter, Franziska, Chouchani, Edward T., Słabicki, Mikołaj, Fischer, Eric S., Ebert, Benjamin L., Hinshaw, Stephen M., Gray, Nathanael S.

“…Targeted protein degradation relies on small molecules that induce new protein–protein interactions between targets and the cellular protein degradation…”
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Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library by Razumkov, Hlib, Jiang, Zixuan, Baek, Kheewoong, You, Inchul, Geng, Qixiang, Donovan, Katherine A., Tang, Michelle T., Metivier, Rebecca J., Mageed, Nada, Seo, Pooreum, Li, Zhengnian, Byun, Woong Sub, Hinshaw, Stephen M., Sarott, Roman C., Fischer, Eric S., Gray, Nathanael S.

“…Small molecules promoting protein-protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their…”
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Relocalizing transcriptional kinases to activate apoptosis by Sarott, Roman C, Gourisankar, Sai, Karim, Basel, Nettles, Sabin, Yang, Haopeng, Dwyer, Brendan G, Simanauskaite, Juste M, Tse, Jason, Abuzaid, Hind, Krokhotin, Andrey, Zhang, Tinghu, Hinshaw, Stephen M, Green, Michael R, Crabtree, Gerald R, Gray, Nathanael S

“…Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are…”
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Structure-Based Design of Y‑Shaped Covalent TEAD Inhibitors by Lu, Wenchao, Fan, Mengyang, Ji, Wenzhi, Tse, Jason, You, Inchul, Ficarro, Scott B., Tavares, Isidoro, Che, Jianwei, Kim, Audrey Y., Zhu, Xijun, Boghossian, Andrew, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Hinshaw, Stephen M., Nabet, Behnam, Corsello, Steven M., Kwiatkowski, Nicholas, Marto, Jarrod A., Zhang, Tinghu, Gray, Nathanael S.

“…Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional…”
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Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) by Ji, Wenzhi, Du, Guangyan, Jiang, Jie, Lu, Wenchao, Mills, Caitlin E., Yuan, Linjie, Jiang, Fen, He, Zhixiang, Bradshaw, Gary A., Chung, Mirra, Jiang, Zixuan, Byun, Woong Sub, Hinshaw, Stephen M., Zhang, Tinghu, Gray, Nathanael S.

“…Cyclin-dependent kinase 7, along with cyclin H and MAT1, forms the CDK-activating complex (CAK), which directs cell cycle progression via T-loop…”
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Correction: The structure of the Ctf19c/CCAN from budding yeast by Hinshaw, Stephen M, Harrison, Stephen C

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The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication by Carocci, Margot, Hinshaw, Stephen M, Rodgers, Mary A, Villareal, Valerie A, Burri, Dominique J, Pilankatta, Rajendra, Maharaj, Natalya P, Gack, Michaela U, Stavale, Eric J, Warfield, Kelly L, Yang, Priscilla L

“…Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV…”
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