Search Results - "Hinshaw, Dominique C."

The Tumor Microenvironment Innately Modulates Cancer Progression by Hinshaw, Dominique C, Shevde, Lalita A

“…Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment…”
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Merlin deficiency alters the redox management program in breast cancer by Mota, Mateus, Metge, Brandon J., Hinshaw, Dominique C., Alsheikh, Heba A., Chen, Dongquan, Samant, Rajeev S., Shevde, Lalita A.

“…The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. In order…”
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Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy by Metge, Brandon J., Alsheikh, Heba A., Chen, Dongquan, Elhamamsy, Amr R., Hinshaw, Dominique C., Chen, Bo-Ruei, Sleckman, Barry P., Samant, Rajeev S., Shevde, Lalita A.

“…Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by…”
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Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages by Hinshaw, Dominique C, Hanna, Ann, Lama-Sherpa, Tshering, Metge, Brandon, Kammerud, Sarah C, Benavides, Gloria A, Kumar, Atul, Alsheikh, Heba Allah, Mota, Mateus, Chen, Dongquan, Ballinger, Scott W, Rathmell, Jeffrey C, Ponnazhagan, Selvarangan, Darley-Usmar, Victor, Samant, Rajeev S, Shevde, Lalita A

“…Elevated infiltration of immunosuppressive alternatively polarized (M2) macrophages is associated with poor prognosis in patients with cancer. The tumor…”
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A Metabolic Axis of Immune Intractability by Hinshaw, Dominique C, Patel, Meet, Shevde, Lalita A

“…Immune cells in the tumor niche robustly influence disease progression. Remarkably, in cancer, developmental pathways are reenacted. Many parallels between…”
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Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study by Duvivier, Herbert L, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Ahn, Eugene R, Al Baghdadi, Tareq, Alva, Ajjai S, Dublis, Stephanie A, Cannon, Timothy L, Calfa, Carmen J, Li, Rui, Behl, Deepti, Chiu, Vi K, Gold, Philip J, Marr, Alissa S, Mileham, Kathryn F, Powell, Steven Francis, Rodon, Jordi, Thota, Ramya, Grantham, Gina N, Gregory, Abigail, Hinshaw, Dominique C, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a pragmatic basket trial evaluating antitumor activity of approved targeted agents in…”
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Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinoma by Hinshaw, Dominique C., Swain, Courtney A., Chen, Dongquan, Hanna, Ann, Molina, Patrick A., Maynard, Craig L., Lee, Goo, McFarland, Braden C., Samant, Rajeev S., Shevde, Lalita A.

“…Given the gut microbiome's rise as a potential frontier in cancer pathogenesis and therapy, leveraging microbial analyses in the study of breast tumor…”
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Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study by Cannon, Timothy L, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Chiu, Vi K, Hwang, Jimmy, Vijayvergia, Namrata, Alese, Olatunji B, Dib, Elie G, Duvivier, Herbert L, Klute, Kelsey A, Sahai, Vaibhav, Ahn, Eugene R, Bedano, Pablo, Behl, Deepti, Sinclair, Sarah, Thota, Ramya, Urba, Walter J, Yang, Eddy S, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in…”
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Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding by Alsheikh, Heba Allah M., Metge, Brandon J., Ha, Chae‐Myeong, Hinshaw, Dominique C., Mota, Mateus S.V., Kammerud, Sarah C., Lama-Sherpa, Tshering, Sharafeldin, Noha, Wende, Adam R., Samant, Rajeev S., Shevde, Lalita A.

“…Obesity and diabetes cumulatively create a distinct systemic metabolic pathophysiological syndrome that predisposes patients to several diseases including…”
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Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape by Lama-Sherpa, Tshering D, Das, Shamik, Hinshaw, Dominique C, Kammerud, Sarah C, Song, Patrick N, Alsheikh, Heba A, Sorace, Anna G, Samant, Rajeev S, Shevde, Lalita A

“…Metastases account for the majority of mortalities related to breast cancer. The onset and sustained presence of hypoxia strongly correlates with increased…”
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Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer by Hinshaw, Dominique C, Benavides, Gloria A, Metge, Brandon J, Swain, Courtney A, Kammerud, Sarah C, Alsheikh, Heba A, Elhamamsy, Amr, Chen, Dongquan, Darley-Usmar, Victor, Rathmell, Jeffrey C, Welner, Robert S, Samant, Rajeev S, Shevde, Lalita A

“…The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth…”
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O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity by Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Hanna, Ann, Hinshaw, Dominique C., Mota, Mateus, Forero-Torres, Andres, Chatham, John C., Samant, Rajeev S., Shevde, Lalita A.

“…Modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) promotes tumor cell survival, proliferation, epigenetic changes, angiogenesis, invasion,…”
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Talazoparib in Patients With Solid Tumors With BRCA1 / 2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study by Srkalovic, Gordan, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Ahn, Eugene R, Brouse, Gregory, Chan, John, Mehmi, Inderjit, Khalil, Maya, Duvivier, Herbert L, Gaba, Anu, Leuva, Harshraj, Thota, Ramya, Yost, Kathleen J, Grantham, Gina N, Gregory, Abigail, Hinshaw, Dominique C, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry Study is a phase II basket trial evaluating the antitumor activity of commercially available targeted…”
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Palbociclib in Patients With Soft Tissue Sarcoma With CDK4 Amplifications: Results From the Targeted Agent and Profiling Utilization Registry Study by Schuetze, Scott, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Meric-Bernstam, Funda, Calfa, Carmen J, Farrington, Laura Catherine, Livingston, Michael B, Wentzel, Kristopher, Behl, Deepti, Kier, Yelena, Marr, Alissa S, von Mehren, Margaret, Press, Joshua Z, Thota, Ramya, Grantham, Gina N, Gregory, Abigail, Hinshaw, Dominique C, Halabi, Susan, Schilsky, Richard L

“…Targeted Agent and Profiling Utilization Registry (TAPUR) is a phase II basket trial evaluating the antitumor activity of commercially available targeted…”
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Regorafenib in Patients With Solid Tumors With BRAF Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study by Sahai, Vaibhav, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Suhag, Vijay, Dib, Elie G, Mehmi, Inderjit, Kadakia, Kunal C, Pisick, Evan, Duvivier, Herbert L, Le, Phat, Li, Rui, Michelin, David P, Wilcox, Ryan E, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in…”
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Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study by Worden, Francis P, Pisick, Evan, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Khalil, Maged F, Carrizosa, Daniel R, Bauman, Jessica R, Leidner, Rom S, Duvivier, Herbert L, Fu, Siqing, Park, Min S, Yost, Kathleen J, Calfa, Carmen J, Marr, Alissa S, Balmanoukian, Ani S, Behl, Deepti, Cannon, Timothy L, Nabell, Lisle, Powell, Steven Francis, Thota, Ramya, Hinshaw, Dominique C, Gregory, Abigail, Grantham, Gina N, Halabi, Susan, Schilsky, Richard L

“…Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in…”
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Sunitinib in Patients With Breast Cancer With FGFR1 or FGFR2 Amplifications or Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study by Calfa, Carmen J, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Ahn, Eugene R, Burness, Monika L, Gogineni, Keerthi, Rohatgi, Nitin, Al Baghdadi, Tareq, Conlin, Alison, Gaba, Anu, Hamid, Omid, Krishnamurthy, Jairam, Gavini, Naga Jyothi, Gold, Philip J, Rodon, Jordi, Rueter, Jens, Thota, Ramya, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry Study is a phase II basket trial evaluating the antitumor activity of commercially available targeted…”
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Cobimetinib Plus Vemurafenib in Patients With Solid Tumors With BRAF Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study by Meric-Bernstam, Funda, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Gutierrez, Rodolfo, Ahn, Eugene R, Cannon, Timothy L, Powell, Steven, Krauss, John C, Reynolds, Christopher M, von Mehren, Margaret, Behl, Deepti, Calfa, Carmen J, Duvivier, Herbert L, Kaplan, Henry G, Livingston, Michael B, Sharma, Manish R, Urba, Walter J, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry Study is a phase II basket study evaluating antitumor activity of commercially available targeted agents…”
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Nivolumab Plus Ipilimumab in Patients With Solid Tumors With ATM Mutations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study by Rohatgi, Nitin, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Meric-Bernstam, Funda, Pisick, Evan, Alese, Olatunji B, Reynolds, Christopher M, Thota, Ramya, Vaccaro, Gina M, von Mehren, Margaret, Arend, Rebecca C, Chiu, Vi K, Duvivier, Herbert L, Gold, Philip J, Hack, Keely, Marr, Alissa S, Winer, Arthur, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry Study is a phase II basket study evaluating the antitumor activity of commercially available targeted…”
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Hedgehog signaling interfaces with the Hexoseamine Biosynthetic Pathway to promote M2 polarization of mammary tumor associated macrophages by Hinshaw, Dominique C, Hanna, Ann, Samant, Rajeev, Shevde-Samant, Lalita

“…Abstract The Hedgehog (Hh) signaling pathway is aberrantly activated in breast cancer, and contributes to tumor cell survival, proliferation, and migration…”
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