Search Results - "Hinrichs, Anthony L"

Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking by Stevens, Victoria L, Bierut, Laura J, Talbot, Jeffrey T, Wang, Jen C, Sun, Juzhong, Hinrichs, Anthony L, Thun, Michael J, Goate, Alison, Calle, Eugenia E

“…Heavy smoking is a strong predictor of nicotine dependence, which is a major impediment to smoking cessation. Although both heavy smoking and nicotine…”
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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes by Saccone, Nancy L., Saccone, Scott F., Hinrichs, Anthony L., Stitzel, Jerry A., Duan, Weimin, Pergadia, Michele L., Agrawal, Arpana, Breslau, Naomi, Grucza, Richard A., Hatsukami, Dorothy, Johnson, Eric O., Madden, Pamela A.F., Swan, Gary E., Wang, Jen C., Goate, Alison M., Rice, John P., Bierut, Laura J.

“…Tobacco smoking continues to be a leading cause of preventable death. Recent research has underscored the important role of specific cholinergic nicotinic…”
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The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European–Americans by Bloom, Joseph, Hinrichs, Anthony L, Wang, Jen C, von Weymarn, Linda B, Kharasch, Evan D, Bierut, Laura J, Goate, Alison, Murphy, Sharon E

“…OBJECTIVETo study the association between cytochrome P450 2A6 (CYP2A6) genotype and metabolism of nicotine to cotinine, identify functional polymorphisms, and…”
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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks by Kapoor, Manav, Wang, Jen-Chyong, Wetherill, Leah, Le, Nhung, Bertelsen, Sarah, Hinrichs, Anthony L., Budde, John, Agrawal, Arpana, Bucholz, Kathleen, Dick, Danielle, Harari, Oscar, Hesselbrock, Victor, Kramer, John, Nurnberger, John I., Rice, John, Saccone, Nancy, Schuckit, Marc, Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J., Bierut, Laura, Foroud, Tatiana, Goate, Alison

“…Maximum number of alcoholic drinks consumed in a 24-h period (maxdrinks) is a heritable (>50 %) trait and is strongly correlated with vulnerability to…”
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Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families by Kapoor, Manav, Wang, Jen-Chyong, Wetherill, Leah, Le, Nhung, Bertelsen, Sarah, Hinrichs, Anthony L, Budde, John, Agrawal, Arpana, Almasy, Laura, Bucholz, Kathleen, Dick, Danielle M, Harari, Oscar, Xiaoling, Xuei, Hesselbrock, Victor, Kramer, John, Nurnberger, John I, Rice, John, Schuckit, Marc, Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J, Bierut, Laura, Foroud, Tatiana, Goate, Alison

“…Abstract Background The age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study…”
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Association of Late-Onset Alzheimer's Disease with Genetic Variation in Multiple Members of the GAPD Gene Family by Li, Yonghong, Nowotny, Petra, Holmans, Peter, Smemo, Scott, John S. K. Kauwe, Hinrichs, Anthony L., Tacey, Kristina, Doil, Lisa, van Luchene, Ryan, Garcia, Veronica, Rowland, Charles, Schrodi, Steve, Leong, Diane, Gogic, Goran, Chan, Joanne, Cravchik, Anibal, Ross, David, Lau, Kit, Kwok, Shirley, Chang, Sheng-Yung, Catanese, Joe, Sninsky, John, White, Thomas J., Hardy, John, Powell, John, Lovestone, Simon, Morris, John C., Thal, Leon, Owen, Michael, Williams, Julie, Goate, Alison, Grupe, Andrew, Snyder, Solomon H.

“…Although several genes have been implicated in the development of the early-onset autosomal dominant from of Alzheimer's disease (AD), the genetics of…”
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genome-wide association study of alcohol dependence by Bierut, Laura J, Agrawal, Arpana, Bucholz, Kathleen K, Doheny, Kimberly F, Laurie, Cathy, Pugh, Elizabeth, Fisher, Sherri, Fox, Louis, Howells, William, Bertelsen, Sarah, Hinrichs, Anthony L, Almasy, Laura, Breslau, Naomi, Culverhouse, Robert C, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Grucza, Richard A, Hatsukami, Dorothy, Hesselbrock, Victor, Johnson, Eric O, Kramer, John, Krueger, Robert F, Kuperman, Samuel, Lynskey, Michael, Mann, Karl, Neuman, Rosalind J, Nöthen, Markus M, Nurnberger, John I. Jr, Porjesz, Bernice, Ridinger, Monika, Saccone, Nancy L, Saccone, Scott F, Schuckit, Marc A, Tischfield, Jay A, Wang, Jen C, Rietschel, Marcella, Goate, Alison M, Rice, John P

“…Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria…”
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Variants in Nicotinic Receptors and Risk for Nicotine Dependence by Bierut, Laura Jean, Stitzel, Jerry A., Wang, Jen C., Hinrichs, Anthony L., Grucza, Richard A., Xuei, Xiaoling, Saccone, Nancy L., Saccone, Scott F., Bertelsen, Sarah, Fox, Louis, Horton, William J., Breslau, Naomi, Budde, John, Cloninger, C. Robert, Dick, Danielle M., Foroud, Tatiana, Hatsukami, Dorothy, Hesselbrock, Victor, Johnson, Eric O., Kramer, John, Kuperman, Samuel, Madden, Pamela A.F., Mayo, Kevin, Nurnberger, John, Pomerleau, Ovide, Porjesz, Bernice, Reyes, Oliver, Schuckit, Marc, Swan, Gary, Tischfield, Jay A., Edenberg, Howard J., Rice, John P., Goate, Alison M.

“…Objective: A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine…”
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Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs by Saccone, Scott F., Hinrichs, Anthony L., Saccone, Nancy L., Chase, Gary A., Konvicka, Karel, Madden, Pamela A.F., Breslau, Naomi, Johnson, Eric O., Hatsukami, Dorothy, Pomerleau, Ovide, Swan, Gary E., Goate, Alison M., Rutter, Joni, Bertelsen, Sarah, Fox, Louis, Fugman, Douglas, Martin, Nicholas G., Montgomery, Grant W., Wang, Jen C., Ballinger, Dennis G., Rice, John P., Bierut, Laura Jean

“…Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we…”
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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans by Saccone, Nancy L, Wang, Jen C, Breslau, Naomi, Johnson, Eric O, Hatsukami, Dorothy, Saccone, Scott F, Grucza, Richard A, Sun, Lingwei, Duan, Weimin, Budde, John, Culverhouse, Robert C, Fox, Louis, Hinrichs, Anthony L, Steinbach, Joseph Henry, Wu, Meng, Rice, John P, Goate, Alison M, Bierut, Laura J

“…Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome…”
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Novel genes identified in a high-density genome wide association study for nicotine dependence by Bierut, Laura Jean, Madden, Pamela A.F., Breslau, Naomi, Johnson, Eric O., Hatsukami, Dorothy, Pomerleau, Ovide F., Swan, Gary E., Rutter, Joni, Bertelsen, Sarah, Fox, Louis, Fugman, Douglas, Goate, Alison M., Hinrichs, Anthony L., Konvicka, Karel, Martin, Nicholas G., Montgomery, Grant W., Saccone, Nancy L., Saccone, Scott F., Wang, Jen C., Chase, Gary A., Rice, John P., Ballinger, Dennis G.

“…Tobacco use is a leading contributor to disability and death worldwide, and genetic factors contribute in part to the development of nicotine dependence. To…”
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A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence by Grucza, Richard A, Wang, Jen C, Stitzel, Jerry A, Hinrichs, Anthony L, Saccone, Scott F, Saccone, Nancy L, Bucholz, Kathleen K, Cloninger, C. Robert, Neuman, Rosalind J, Budde, John P, Fox, Louis, Bertelsen, Sarah, Kramer, John, Hesselbrock, Victor, Tischfield, Jay, Nurnberger, John I, Almasy, Laura, Porjesz, Bernice, Kuperman, Samuel, Schuckit, Marc A, Edenberg, Howard J, Rice, John P, Goate, Alison M, Bierut, Laura J

“…Background A nonsynonymous coding polymorphism, rs16969968, of the CHRNA5 gene that encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR)…”
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HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin by Mukherjee, Odity, Pastor, Pau, Cairns, Nigel J., Chakraverty, Sumi, Kauwe, John S. K., Shears, Shantia, Behrens, Maria I., Budde, John, Hinrichs, Anthony L., Norton, Joanne, Levitch, Denise, Taylor-Reinwald, Lisa, Gitcho, Michael, Tu, P.-H., Tenenholz Grinberg, Lea, Liscic, Rajka M., Armendariz, Javier, Morris, John C., Goate, Alison M.

“…Objective Familial autosomal dominant frontotemporal dementia with ubiquitin‐positive, tau‐negative inclusions in the brain linked to 17q21‐22 recently has…”
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Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome by Wang, Jen C., Hinrichs, Anthony L., Stock, Heather, Budde, John, Allen, Rebecca, Bertelsen, Sarah, Kwon, Jennifer M., Wu, William, Dick, Danielle M., Rice, John, Jones, Kevin, Nurnberger, John I., Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J., Hesselbrock, Victor, Crowe, Ray, Schuckit, Mark, Begleiter, Henri, Reich, Theodore, Goate, Alison M., Bierut, Laura J.

“…Several correlated phenotypes, alcohol dependence, major depressive syndrome, and an endophenotype of electrophysiological measurements, event-related…”
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Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample by Agrawal, Arpana, Edenberg, Howard J, Foroud, Tatiana, Bierut, Laura J, Dunne, Gerald, Hinrichs, Anthony L, Nurnberger, John I, Crowe, Raymond, Kuperman, Samuel, Schuckit, Marc A, Begleiter, Henri, Porjesz, Bernice, Dick, Danielle M

“…Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative…”
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Population stratification and patterns of linkage disequilibrium by Hinrichs, Anthony L., Larkin, Emma K., Suarez, Brian K.

“…Although the importance of selecting cases and controls from the same population has been recognized for decades, the recent advent of genome‐wide association…”
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Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin by Wang, Jen C., Hinrichs, Anthony L., Bertelsen, Sarah, Stock, Heather, Budde, John P., Dick, Danielle M., Bucholz, Kathleen K., Rice, John, Saccone, Nancy, Edenberg, Howard J., Hesselbrock, Victor, Kuperman, Samuel, Schuckit, Marc A., Bierut, Laura J., Goate, Alison M.

“…Background: A novel family of G protein‐coupled receptors, TAS2Rs, has recently been characterized and linked to sensitivity to bitter taste compounds. We have…”
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Incorporating linkage information into a common disease/rare variant framework by Hinrichs, Anthony L., Suarez, Brian K.

“…Recent developments in sequencing technology have allowed the investigation of the common disease/rare variant hypothesis. In the Genetic Analysis Workshop 17…”
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Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence by Chen, Li-Shiun, Johnson, Eric O., Breslau, Naomi, Hatsukami, Dorothy, Saccone, Nancy L., Grucza, Richard A., Wang, Jen C., Hinrichs, Anthony L., Fox, Louis, Goate, Alison M., Rice, John P., Bierut, Laura J.

“…ABSTRACT Background  Several studies have found replicable associations between nicotine dependence and specific variants in the nicotinic receptor genes…”
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Cortical Binding of Pittsburgh Compound B, an Endophenotype for Genetic Studies of Alzheimer's Disease by Hinrichs, Anthony L, Mintun, Mark A, Head, Denise, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M

“…Background To date, all known Alzheimer's disease genes influence amyloid beta (Aβ). Imaging of Aβ deposition in the human brain using Pittsburgh Compound B…”
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