Search Results - "Hino, O."

Low FOXA1 expression predicts good response to neo-adjuvant chemotherapy resulting in good outcomes for luminal HER2-negative breast cancer cases by Horimoto, Y, Arakawa, A, Harada-Shoji, N, Sonoue, H, Yoshida, Y, Himuro, T, Igari, F, Tokuda, E, Mamat, O, Tanabe, M, Hino, O, Saito, M

“…Background: FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer…”
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Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature by Kunogi, Makiko, Kurihara, Masatoshi, Ikegami, Takako Shigihara, Kobayashi, Toshiyuki, Shindo, Noriko, Kumasaka, Toshio, Gunji, Yoko, Kikkawa, Mika, Iwakami, Shin-ichiro, Hino, Okio, Takahashi, Kazuhisa, Seyama, Kuniaki

“…Birt-Hogg-Dubé syndrome (BHDS) is an inherited autosomal genodermatosis characterised by fibrofolliculomas of the skin, renal tumours and multiple lung cysts…”
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Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL Fnip2) protein by Takagi, Y, Kobayashi, T, Shiono, M, Wang, L, Piao, X, Sun, G, Zhang, D, Abe, M, Hagiwara, Y, Takahashi, K, Hino, O

“…Birt-Hogg-Dubé (BHD) syndrome is characterized by the development of pneumothorax, hair folliculomas and renal tumors and the responsible BHD gene is thought…”
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Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis by Sato, Teruhiko, Seyama, Kuniaki, Fujii, Hiroaki, Maruyama, Hiroshi, Setoguchi, Yasuhiro, Iwakami, Shin-ichiro, Fukuchi, Yoshinosuke, Hino, Okio

“…Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease characterized by a diffuse hamartomatous proliferation of smooth muscle cells (LAM…”
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Transgenic rescue from embryonic lethality and renal carcinogenesis in the nihon rat model by introduction of a wild-type Bhd gene by TOGASHI, Y, KOBAYASHI, T, MOMOSE, S, UEDA, M, OKIMOTO, K, HINO, O

“…We recently reported that a germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé gene (BHD) gives rise to dominantly…”
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The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition by Shiono, M, Kobayashi, T, Takahashi, R, Sun, G, Abe, M, Zhang, D, Wang, L, Piao, X, Takagi, Y, Mineki, R, Taka, H, Tada, N, Sonobe, S, Momose, S, Ueda, M, Hino, O

“…Tuberin, a tumor-suppressor protein produced by the tuberous sclerosis gene TSC2 , downregulates the Rheb-mTOR-S6K pathway (mTOR axis). Comparison of the…”
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Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors by Obulhasim, G, Fujii, H, Matsumoto, T, Yasen, M, Abe, M, Matsuoka, S, Ohtsuji, N, Hino, O

“…Mesothelin is a cell surface glycoprotein that is present on normal mesothelial cells and overexpressed in several cancers. In this study, we investigated the…”
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Expression of cyclooxygenase-1 and -2 mRNA in rat tissues: tissue-specific difference in the expression of the basal level of mRNA by Okamoto, T, Hino, O

“…The expression of cyclooxygenase (Cox)-1 and -2 mRNA was studied in tissues of Fisher 344 (F344) (n=3) and Brown Norway (BN) (n=3) strain rats using the…”
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Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability by Fujii, H, Jiang, W, Matsumoto, T, Miyai, K, Sashara, K, Ohtsuji, N, Hino, O

“…Birt–Hogg–Dubé (BHD) syndrome is a rare form of autosomal dominantly inherited genodermatosis characterized by benign hamartomatous skin lesions named…”
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Allelic loss analysis of early-stage flat-type colorectal tumors by Orita, H., Sakamoto, N., Ajioka, Y., Terai, T., Hino, O., Sato, N., Shimoda, T., Kamano, T., Tsurumaru, M., Fujii, H.

“…Background: Flat-type colorectal tumors are rare, but are known for their unusual flat morphology and aggressive clinical behavior despite their small size. To…”
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A patient with TSC1 germline mutation whose clinical phenotype was limited to lymphangioleiomyomatosis by Sato, T., Seyama, K., Kumasaka, T., Fujii, H., Setoguchi, Y., Shirai, T., Tomino, Y., Hino, O., Fukuchi, Y.

“… Background:  Lymphangioleiomyomatosis (LAM) can occur as in isolated form (sporadic LAM) or as a pulmonary manifestation of tuberous sclerosis complex (TSC)…”
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Chronic Active Hepatitis in Transgenic Mice Expressing Interferon-γ in the Liver by Toyonaga, Tetsushi, Hino, Okio, Sugai, Satoshi, Wakasug, Shoji, Abe, Kuniya, Shichiri, Motoaki, Yamamura, Ken-Ichi

“…Interferon-γ may play an important role in the immune response and in inflammatory diseases, including chronic active hepatitis. To understand the role of…”
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Hypercarcinogenic state by Hino, O

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Drug development with hints from traditional Indian Ayurveda medicine: hepatitis and rheumatoid as an example by Okamoto, T, Hino, O

“…Although many drugs have been developed by pharmaceutical companies, there are many diseases which can not be cured with these drugs. In order to overcome this…”
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Cancer genetics of TSC2 gene mutant(Eker) rat model by Hino, O

“…Cancer is a heritable disorder of somatic cells. Environment and heredity both operate in the origin of human cancer. Hereditary cancers have been important in…”
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The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene by Hino, O, Kobayashi, T, Tsuchiya, H, Kikuchi, Y, Kobayashi, E, Mitani, H, Hirayama, Y

“…The Eker rat is a promising animal model of cancer predisposition syndromes. In this study, using 129 backcross animals, we have established a new conserved…”
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Expression and Replication of Hepatitis B Virus Genome in Transgenic Mice by Araki, Kimi, Miyazaki, Jun-Ichi, Hino, Okio, Tomita, Naohiro, Chisaka, Osamu, Matsubara, Kenichi, Yamamura, Ken-Ichi

“…We produced transgenic mice by microinjecting a partial tandem duplication of the complete hepatitis B virus (HBV) genome into fertilized eggs of C57BL/6 mice…”
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beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice by Umeda, T, Yamamoto, T, Kajino, K, Hino, O

“…beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes…”
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Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat : Detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo by FUKUDA, Tomokazu, KOBAYASHI, Toshiyuki, MOMOSE, Shuji, YASUI, Hideaki, HINO, Okio

“…We and others previously demonstrated that hereditary mutation and a subsequent second hit in the rat homolog of tuberous sclerosis gene (Tsc2) are responsible…”
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Evidence for Increased in vitro Recombination with Insertion of Human Hepatitis B Virus DNA by Hino, Okio, Tabata, Satoshi, Hotta, Yasuo

“…Chromosomal translocation, deletion, and inversion/duplication directly linked to hepatitis B virus (HBV) DNA integration occur frequently in host DNA of human…”
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