Search Results - "Hinke, SA"

Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors by HANSOTIA, Tanya, BAGGIO, Laurie L, DELMEIRE, Dominique, HINKE, Simon A, YAMADA, Yuichiro, TSUKIYAMA, Katsushi, SEINO, Yutaka, HOLST, Jens J, SCHUIT, Frans, DRUCKER, D. J

“…Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV…”
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Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal by Hinke, Simon A., Hellemans, Karine, Schuit, Frans C.

“…It is well established that the acute rise in plasma glucose and in the incretin hormones glucose‐dependent insulinotropic peptide (GIP) and glucagon‐like…”
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Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1 by DELMEIRE, D, FLAMEZ, D, HINKE, S. A, CALI, J. J, PIPELEERS, D, SCHUIT, F

“…The secretory function of pancreatic beta cells is synergistically stimulated by two signalling pathways which mediate the effects of nutrients and hormones…”
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Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide by Hinke, SA, Pauly, RP, Ehses, J, Kerridge, P, Demuth, HU, McIntosh, CH, Pederson, RA

“…It is well documented that the release of insulin from isolated perifused islets attenuates over time, despite a continued glucose stimulation. In the current…”
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Metformin Effects on Dipeptidylpeptidase IV Degradation of Glucagon-like Peptide-1 by Hinke, Simon A., Kühn-Wache, Kerstin, Hoffmann, Torsten, Pederson, Raymond A., McIntosh, Christopher H.S., Demuth, Hans-Ulrich

“…There is current interest in the use of inhibitors of dipeptidyl peptidase IV (DP IV) as therapeutic agents to normalize glycemic excursions in type 2 diabetic…”
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Dipeptidyl Peptidase IV-Resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats by HINKE, Simon A, GELLING, Richard W, PEDERSON, Raymond A, MANHART, Susanne, CUILAN NIAN, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S

“…Dipeptidyl Peptidase IV-Resistant [ d -Ala 2 ]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats…”
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Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis by Pamir, Nathalie, Lynn, Francis C, Buchan, Alison M J, Ehses, Jan, Hinke, Simon A, Pospisilik, J Andrew, Miyawaki, Kazumasa, Yamada, Yuichiro, Seino, Yutaka, McIntosh, Christopher H S, Pederson, Raymond A

“…The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut hormones that act via the enteroinsular axis to…”
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A novel pathway for regulation of glucose‐dependent insulinotropic polypeptide receptor expression in β‐cells by Lynn, Francis C., Thompson, Stephen A., Pospisilik, J. Andrew, Ehses, Jan A., Hinke, Simon A., Pamir, Nathalie, McIntosh, Christopher H. S., Pederson, Raymond A.

“…ABSTRACT Glucose‐dependent insulinotropic polypeptide (GIP) is secreted postprandially and acts in concert with glucose to stimulate insulin secretion from the…”
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Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs by Hinke, S A, Pospisilik, J A, Demuth, H U, Mannhart, S, Kühn-Wache, K, Hoffmann, T, Nishimura, E, Pederson, R A, McIntosh, C H

“…Over the past decade, numerous studies have been targeted at defining structure-activity relationships of glucagon. Recently, we have found that glucagon(1-29)…”
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Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness by Delmeire, Dominique, Flamez, Daisy, Moens, Karen, Hinke, Simon A, Van Schravendijk, Chris, Pipeleers, Daniel, Schuit, Frans

“…Glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent insulinotropic peptide (GIP) potentiate glucose-induced insulin release when present at the…”
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Structure−Function Analysis of a Series of Novel GIP Analogues Containing Different Helical Length Linkers by Manhart, Susanne, Hinke, Simon A, McIntosh, Christopher H. S, Pederson, Raymond A, Demuth, Hans-Ulrich

“…Glucose-dependent insulinotropic polypeptide (GIP1 - 42) is a potent glucose-lowering intestinal peptide hormone. The equipotent GIP1 - 30NH2 was structurally…”
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[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo by Hinke, Simon A, Manhart, Susanne, Kühn-Wache, Kerstin, Nian, Cuilan, Demuth, Hans-Ulrich, Pederson, Raymond A, McIntosh, Christopher H S

“…Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP; also known as gastric inhibitory polypeptide) are incretin hormones that…”
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In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide by Hinke, Simon A, Manhart, Susanne, Speck, Madeleine, Pederson, Raymond A, Demuth, Hans-Ulrich, McIntosh, Christopher H.S

“…Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) is an important gastrointestinal regulator of insulin release and glucose…”
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Metabolism of glucagon by dipeptidyl peptidase IV (CD26) by Pospisilik, John A, Hinke, Simon A, Pederson, Raymond A, Hoffmann, Torsten, Rosche, Fred, Schlenzig, Dagmar, Glund, Konrad, Heiser, Ulrich, McIntosh, Christopher H.S, Demuth, Hans-Ulrich

“…Glucagon is a 29-amino acid polypeptide released from pancreatic islet α-cells that acts to maintain euglycemia by stimulating hepatic glycogenolysis and…”
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Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin by McIntosh, C H, Bremsak, I, Lynn, F C, Gill, R, Hinke, S A, Gelling, R, Nian, C, McKnight, G, Jaspers, S, Pederson, R A

“…GIP is an important insulinotropic hormone (incretin) that has also been implicated in fat metabolism. There is controversy regarding the actions of GIP on…”
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Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP) by Hinke, Simon A, Gelling, Rick, Manhart, Susanne, Lynn, Francis, Pederson, Raymond A, Kühn-Wache, Kerstin, Rosche, Fred, Demuth, Hans-Ulrich, Coy, David, McIntosh, Christopher H S

“…Six GIP(1-NH2) analogs were synthesized with modifications (de-protonation, N-methylation, reversed chirality, and substitution) at positions 1, 3, and 4 of…”
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Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization by Wheeler, M B, Gelling, R W, Hinke, S A, Tu, B, Pederson, R A, Lynn, F, Ehses, J, McIntosh, C H

“…Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone involved in the regulation of insulin secretion. In non-insulin-dependent…”
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On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors by Hinke, Simon A, McIntosh, Christopher H S, Hoffmann, Torsten, Kühn-Wache, Kerstin, Wagner, Leona, Bär, Joachim, Manhart, Susanne, Wermann, Michael, Pederson, Raymond A, Demuth, Hans-Ulrich

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Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential by Hinke, Simon A, Lynn, Francis, Ehses, Jan, Pamir, Nathalie, Manhart, Susanne, Kühn-Wache, Kerstin, Rosche, Fred, Demuth, Hans-Ulrich, Pederson, Raymond A, McIntosh, Christopher H S

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Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP) by Hinke, Simon A, Manhart, Susanne, Pamir, Nathalie, Demuth, Hans-Ulrich, W. Gelling, Richard, Pederson, Raymond A, McIntosh, Christopher H.S

“…The incretins are a class of hormones released from the small bowel that act on the endocrine pancreas to potentiate insulin secretion in a glucose-dependent…”
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