Search Results - "Hingorani, Aroon D."

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics by Giambartolomei, Claudia, Vukcevic, Damjan, Schadt, Eric E, Franke, Lude, Hingorani, Aroon D, Wallace, Chris, Plagnol, Vincent

“…Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a…”
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Plasma protein patterns as comprehensive indicators of health by Williams, Stephen A., Kivimaki, Mika, Langenberg, Claudia, Hingorani, Aroon D., Casas, J. P., Bouchard, Claude, Jonasson, Christian, Sarzynski, Mark A., Shipley, Martin J., Alexander, Leigh, Ash, Jessica, Bauer, Tim, Chadwick, Jessica, Datta, Gargi, DeLisle, Robert Kirk, Hagar, Yolanda, Hinterberg, Michael, Ostroff, Rachel, Weiss, Sophie, Ganz, Peter, Wareham, Nicholas J.

“…Proteins are effector molecules that mediate the functions of genes 1 , 2 and modulate comorbidities 3 – 10 , behaviors and drug treatments 11 . They represent…”
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Genetic drug target validation using Mendelian randomisation by Schmidt, Amand F., Finan, Chris, Gordillo-Marañón, Maria, Asselbergs, Folkert W., Freitag, Daniel F., Patel, Riyaz S., Tyl, Benoît, Chopade, Sandesh, Faraway, Rupert, Zwierzyna, Magdalena, Hingorani, Aroon D.

“…Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However,…”
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Mapping the proteo-genomic convergence of human diseases by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Cortes, Adrian, Koprulu, Mine, Wörheide, Maria A, Oerton, Erin, Cook, James, Stewart, Isobel D, Kerrison, Nicola D, Luan, Jian'an, Raffler, Johannes, Arnold, Matthias, Arlt, Wiebke, O'Rahilly, Stephen, Kastenmüller, Gabi, Gamazon, Eric R, Hingorani, Aroon D, Scott, Robert A, Wareham, Nicholas J, Langenberg, Claudia

“…Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic…”
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The druggable genome and support for target identification and validation in drug development by Finan, Chris, Gaulton, Anna, Kruger, Felix A, Lumbers, R Thomas, Shah, Tina, Engmann, Jorgen, Galver, Luana, Kelley, Ryan, Karlsson, Anneli, Santos, Rita, Overington, John P, Hingorani, Aroon D, Casas, Juan P

“…Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease…”
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Synergistic insights into human health from aptamer- and antibody-based proteomic profiling by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Kerrison, Nicola D., Oerton, Erin, Koprulu, Mine, Luan, Jian’an, Hingorani, Aroon D., Williams, Steve A., Wareham, Nicholas J., Langenberg, Claudia

“…Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease…”
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Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants by Borges, Maria Carolina, Haycock, Philip C, Zheng, Jie, Hemani, Gibran, Holmes, Michael V, Davey Smith, George, Hingorani, Aroon D, Lawlor, Deborah A

“…Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence…”
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Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis by López-López, José A, Sterne, Jonathan A C, Thom, Howard H Z, Higgins, Julian P T, Hingorani, Aroon D, Okoli, George N, Davies, Philippa A, Bodalia, Pritesh N, Bryden, Peter A, Welton, Nicky J, Hollingworth, William, Caldwell, Deborah M, Savović, Jelena, Dias, Sofia, Salisbury, Chris, Eaton, Diane, Stephens-Boal, Annya, Sofat, Reecha

“…Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial…”
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Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis by Bellamy, Leanne, Casas, Juan-Pablo, Hingorani, Aroon D, Williams, David J

“…Objective To quantify the risk of future cardiovascular diseases, cancer, and mortality after pre-eclampsia.Design Systematic review and meta-analysis.Data…”
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Selecting instruments for Mendelian randomization in the wake of genome-wide association studies by Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D

“…Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that…”
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Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension by Noori, Muna, Donald, Ann E, Angelakopoulou, Aspasia, Hingorani, Aroon D, Williams, David J

“…Preeclampsia is a life-threatening pregnancy syndrome of uncertain origin. To elucidate the pathogenesis, we evaluated the temporal relationships between…”
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Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study by De Silva, N Maneka G, Borges, Maria Carolina, Hingorani, Aroon D, Engmann, Jorgen, Shah, Tina, Zhang, Xiaoshuai, Luan, Jian'an, Langenberg, Claudia, Wong, Andrew, Kuh, Diana, Chambers, John C, Zhang, Weihua, Jarvelin, Marjo-Ritta, Sebert, Sylvain, Auvinen, Juha, Gaunt, Tom R, Lawlor, Deborah A

“…Liver dysfunction and type 2 diabetes (T2D) are consistently associated. However, it is currently unknown whether liver dysfunction contributes to, results…”
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Adjustment for index event bias in genome-wide association studies of subsequent events by Dudbridge, Frank, Allen, Richard J., Sheehan, Nuala A., Schmidt, A. Floriaan, Lee, James C., Jenkins, R. Gisli, Wain, Louise V., Hingorani, Aroon D., Patel, Riyaz S.

“…Following numerous genome-wide association studies of disease susceptibility, there is increasing interest in genetic associations with prognosis, survival or…”
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Genetic architecture of host proteins involved in SARS-CoV-2 infection by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia

“…Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify…”
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Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study by Talmud, Philippa J, Prof, Shah, Sonia, MSc, Whittall, Ros, MSc, Futema, Marta, BSc, Howard, Philip, BSc, Cooper, Jackie A, MSc, Harrison, Seamus C, MRCS, Li, KaWah, MSc, Drenos, Fotios, PhD, Karpe, Frederik, PhD, Neil, H Andrew W, Prof, Descamps, Olivier S, PhD, Langenberg, Claudia, PhD, Lench, Nicholas, PhD, Kivimaki, Mika, Prof, Whittaker, John, Prof, Hingorani, Aroon D, Prof, Kumari, Meena, PhD, Humphries, Steve E, Prof

“…Summary Background Familial hypercholesterolaemia is a common autosomal-dominant disorder caused by mutations in three known genes. DNA-based cascade testing…”
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PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease by Schmidt, Amand F, Carter, John-Paul L, Pearce, Lucy S, Wilkins, John T, Overington, John P, Hingorani, Aroon D, Casas, J P

“…Despite the availability of effective drug therapies that reduce low-density lipoprotein (LDL)-cholesterol (LDL-C), cardiovascular disease (CVD) remains an…”
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Treatment of Periodontitis and Endothelial Function by Tonetti, Maurizio S, D'Aiuto, Francesco, Nibali, Luigi, Donald, Ann, Storry, Clare, Parkar, Mohamed, Suvan, Jean, Hingorani, Aroon D, Vallance, Patrick, Deanfield, John

“…Epidemiologic data suggest a possible link between periodontal disease and cardiovascular disorders. In this study, patients with severe periodontitis who were…”
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A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service by Kuan, Valerie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Bhatti, Osman, Husain, Shanaz, Sutaria, Shailen, Hingorani, Melanie, Nitsch, Dorothea, Parisinos, Constantinos A, Lumbers, R Thomas, Mathur, Rohini, Sofat, Reecha, Casas, Juan P, Wong, Ian C K, Hemingway, Harry, Hingorani, Aroon D

“…To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know…”
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Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients by Rapsomaniki, Eleni, Shah, Anoop, Perel, Pablo, Denaxas, Spiros, George, Julie, Nicholas, Owen, Udumyan, Ruzan, Feder, Gene Solomon, Hingorani, Aroon D, Timmis, Adam, Smeeth, Liam, Hemingway, Harry

“…The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and…”
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Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study by Dunca, Diana, Chopade, Sandesh, Gordillo-Marañón, María, Hingorani, Aroon D., Kuchenbaecker, Karoline, Finan, Chris, Schmidt, Amand F.

“…CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have…”
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